Nodal Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Nodal
nodal growth differentiation factor
MGI:97359

75 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Acvr1b^tm1Enl/Acvr1b⁺ Gdf1^tm1Sjl/Gdf1⁺ Nodal^tm1Rob/Nodal⁺ involves: 129/Sv * C57BL/6	abnormal forebrain morphology	J:108723
	abnormal nasal septum morphology	J:108723
Acvr1c^tm1Cfi/Acvr1c⁺ Gdf1^tm1Sjl/Gdf1⁺ Nodal^tm1Rob/Nodal⁺ involves: 129 * C57BL/6	no abnormal phenotype detected	J:108723
Acvr1c^tm1Cfi/Acvr1c^tm1Cfi Nodal^tm1Rob/Nodal⁺ involves: 129P2/OlaHsd * 129/Sv	normal mortality/aging	J:94135
Acvr2a^tm1Hsch/Acvr2a^tm1Hsch Nodal^tm1Rob/Nodal⁺ involves: 129S/SvEv * 129S1/Sv * C57BL/6J	abnormal gastrulation	J:57262
	abnormal head morphology	J:57262
	cyclopia	J:57262
	decreased forebrain size	J:57262
	embryonic lethality, complete penetrance	J:57262
Cer1^tm1Bhr/Cer1^tm1Bhr Lefty1^tm1Hmd/Lefty1^tm1Hmd Nodal^tm1Rob/Nodal⁺ involves: 129P2/OlaHsd * 129S/SvEv * 129S7/SvEvBrd * CD-1	abnormal developmental patterning	J:81339
	abnormal embryo development	J:81339
	abnormal embryonic tissue morphology	J:81339
	abnormal embryonic-extraembryonic boundary morphology	J:81339
Cer1^tm1Bhr/Cer1^tm1Bhr Lefty1^tm1Sla/Lefty1^tm1Sla Nodal^tm1Rob/Nodal⁺ involves: 129S/SvEv * 129S7/SvEvBrd * CD-1	abnormal developmental patterning	J:81339
	abnormal embryo development	J:81339
	abnormal embryonic tissue morphology	J:81339
	abnormal embryonic-extraembryonic boundary morphology	J:81339
Chrd^tm1Emdr/Chrd^tm1Emdr Nodal^tm1Rob/Nodal⁺ involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ	abnormal anterior definitive endoderm morphology	J:161524
	abnormal direction of heart looping	J:161524
	abnormal embryonic tissue morphology	J:161524
	abnormal mesendoderm development	J:161524
	abnormal prechordal plate morphology	J:161524
	fused first pharyngeal arch	J:161524
	holoprosencephaly	J:161524
Col2a1^tm1.1Ksec/Col2a1⁺ Nodal^tm1Rob/Nodal⁺ involves: 129S/SvEv * 129X1/SvJ * C57BL/6	abnormal head morphology	J:163739
Col2a1^tm1.1Ksec/Col2a1^tm1.1Ksec Nodal^tm1Rob/Nodal⁺ involves: 129S/SvEv * 129X1/SvJ * C57BL/6	abnormal head morphology	J:163739
Dand5^tm1Belo/Dand5^tm1Belo Nodal^tm1.1Mku/Nodal⁺ involves: 129/Ola * C57BL/6J	abnormal direction of heart looping	J:93051
Drap1^tm1Mms/Drap1^tm1Mms Nodal^tm1Rob/Nodal⁺ involves: 129S/SvEv * 129S6/SvEvTac	abnormal gastrulation	J:80667
	abnormal primitive streak formation	J:80667
	embryonic lethality, complete penetrance	J:80667
Eomes^tm1.1Rob/Eomes⁺ Nodal^tm1Rob/Nodal⁺ involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * CBA	abnormal amniotic cavity morphology	J:131055
	abnormal anterior visceral endoderm cell migration	J:131055
	abnormal developmental patterning	J:131055
	abnormal germ layer development	J:131055
	abnormal left-right axis patterning	J:131055
	abnormal notochord morphology	J:131055
	abnormal primitive node morphology	J:131055
	abnormal rostral-caudal patterning of the somites	J:131055
	disorganized embryonic tissue	J:131055
	embryonic-extraembryonic boundary constriction	J:131055
	enlarged floor plate	J:131055
	failure of primitive streak formation	J:131055
	increased somite number	J:131055
	rostral body truncation	J:131055
	rostral-caudal axis duplication	J:131055
Eomes^tm1.1Rob/Eomes⁺ Nodal^tm4Rob/Nodal^tm4Rob involves: 129S/SvEv * C57BL/6 * CBA	no abnormal phenotype detected	J:131055
Eomes^tm1Rob/Eomes⁺ Nodal^tm1Rob/Nodal⁺ Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ involves: 129S/SvEv * C57BL/6 * CBA	prenatal lethality	J:131055
	rostral body truncation	J:131055
Foxa2^tm1Jrt/Foxa2⁺ Nodal^tm1Rob/Nodal⁺ involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ	abnormal direction of embryo turning	J:32935
	delayed embryo turning	J:32935
	situs ambiguus	J:32935
Gdf1^tm1Sjl/Gdf1^tm1Sjl Nodal^tm1Rob/Nodal⁺ involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal diencephalon morphology	J:108723
	abnormal first pharyngeal arch morphology	J:108723
	abnormal foregut morphology	J:108723
	abnormal mesendoderm development	J:108723
	abnormal neural fold formation	J:108723
	abnormal neural plate morphology	J:108723
	abnormal third ventricle morphology	J:108723
	absent mandible	J:108723
	absent notochord	J:108723
	absent prechordal plate	J:108723
	absent tongue	J:108723
	cleft upper lip	J:108723
	embryonic lethality during organogenesis, incomplete penetrance	J:108723
	fused first pharyngeal arch	J:108723
	holoprosencephaly	J:108723
	nasal septum hypoplasia	J:108723
	truncated notochord	J:108723
Lefty2^tm1Hmd/Lefty2^tm1Hmd Nodal^tm1Rob/Nodal⁺ involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6Cr	abnormal embryo development	J:57907
	embryonic lethality between implantation and somite formation, complete penetrance	J:57907
Nodal^tm1.1Dbc/Nodal^tm1.1Dbc involves: 129S/SvEv * C57BL/6	abnormal mesendoderm development	J:112799
	abnormal primitive streak formation	J:112799
	embryonic growth arrest	J:112799
	embryonic lethality between implantation and somite formation, complete penetrance	J:112799
Nodal^tm1Hmd/Nodal⁺ Tg(Rr443-Lefty1,-lacZ)36Hmd/0 either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)	abnormal cardiac outflow tract development	J:82703
	abnormal digestive system development	J:82703
	abnormal left-right axis patterning	J:82703
	abnormal liver morphology	J:82703
	dextrocardia	J:82703
	right atrial isomerism	J:82703
	right pulmonary isomerism	J:82703
	right-sided isomerism	J:82703
	small spleen	J:82703
Nodal^tm1Rob/Nodal⁺ Nog^tm1Amc/Nog^tm1Amc involves: 129S/SvEv * 129S1/Sv	normal embryo phenotype	J:161524
Nodal^tm1Rob/Nodal⁺ Zic2^Ku/Zic2^Ku 129S.Cg-Nodal^tm1Rob Zic2^Ku	rostral body truncation	J:238567
Nodal^tm1Rob/Nodal⁺ Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ Tgif1^tm1Caw/Tgif1^tm1Caw Tgif2^tm1Dwot/Tgif2^tm1Dwot involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA	abnormal embryonic neuroepithelium morphology	J:183402
	abnormal forebrain development	J:183402
	abnormal left-right axis patterning	J:157256
	normal cardiovascular system phenotype	J:157256
	decreased forebrain size	J:183402
	embryonic growth retardation	J:183402
	holoprosencephaly	J:183402
	rostral body truncation	J:183402
Nodal^tm1Rob/Nodal⁺ Tgif1^tm1Dwot/Tgif1^tm1Dwot Tgif2^tm1Dwot/Tgif2^tm1Dwot involves: 129S/SvEv * 129X1/SvJ * C57BL/6	normal embryo phenotype	J:157256
Nodal^tm1Rob/Nodal⁺ Smad2^tm1.1Epb/Smad2⁺ involves: 129S/SvEv * 129X1/SvJ * C57BL/6J * SJL	abnormal eye development	J:183402
	abnormal olfactory epithelium morphology	J:183402
	embryonic growth retardation	J:183402
	holoprosencephaly	J:183402
	proboscis	J:183402
Nodal^tm1Rob/Nodal⁺ Trim33^tm1.2Los/Trim33^tm1.2Los involves: 129S/SvEv * 129S2/SvPas * C57BL/6	normal embryo phenotype	J:163858
	expanded anterior visceral endoderm	J:163858
Nodal^tm1Rob/Nodal^tm2Rob Trim33^tm1.2Los/Trim33^tm1.2Los involves: 129S/SvEv * 129S2/SvPas * C57BL/6	normal embryo phenotype	J:163858
Nodal^tm2Rob/Nodal⁺ Zic2^Ku/Zic2^Ku 129S.Cg-Nodal^tm2Rob Zic2^Ku	abnormal mesendoderm development	J:238567
	rostral body truncation	J:238567
Nodal^tm2Rob/Nodal^tm2Rob Zic2^Ku/Zic2⁺ 129S.Cg-Nodal^tm2Rob Zic2^Ku	rostral body truncation	J:238567
Nodal^tm2Rob/Nodal^tm2Rob Zic2^Ku/Zic2^Ku 129S.Cg-Nodal^tm2Rob Zic2^Ku	rostral body truncation	J:238567
Smad2^tm1Enl/Smad2⁺ Nodal^tm1Rob/Nodal⁺ involves: 129S/SvEv * 129S4/SvJae	abnormal craniofacial morphology	J:48467
	abnormal direction of embryo turning	J:48467
	abnormal gastrulation	J:48467
	abnormal heart looping	J:48467
	abnormal lateral plate mesoderm morphology	J:48467
	abnormal left-right axis patterning	J:48467
	cyclopia	J:48467
	right pulmonary isomerism	J:48467
	rostral body truncation	J:48467
	transposition of great arteries	J:48467

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