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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Nos3
nitric oxide synthase 3, endothelial cell
MGI:97362
233 phenotypes from 11 alleles in 19 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Nos3em1(IMPC)Mbp/Nos3em1(IMPC)Mbp
C57BL/6N-Nos3em1(IMPC)Mbp/Ucd 		abnormal epididymis morphology J:211773
abnormal kidney morphology J:211773
abnormal lymph node morphology J:211773
abnormal spleen morphology J:211773
decreased circulating phosphate level J:211773
decreased fasting circulating glucose level J:211773
decreased lymphocyte cell number J:211773
enlarged epididymis J:211773
enlarged lymph nodes J:211773
enlarged spleen J:211773
increased basophil cell number J:211773
increased blood urea nitrogen level J:211773
increased eosinophil cell number J:211773
increased heart weight J:211773
increased neutrophil cell number J:211773
small kidney J:211773
Nos3m1Btlr/Nos3m1Btlr
C57BL/6J-Nos3m1Btlr 		increased susceptibility to induced colitis J:225268
increased susceptibility to weight loss J:225268
Nos3M2Btlr/Nos3M2Btlr
C57BL/6J-Nos3M2Btlr 		increased susceptibility to induced colitis J:272392
Nos3tm1.1Taka/Nos3tm1.1Taka
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J 		no abnormal phenotype detected J:187860
Nos3tm1.2Taka/Nos3tm1.2Taka
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA 		abnormal renal glomerulus morphology J:187860
decreased heart rate J:187860
decreased kidney weight J:187860
increased circulating glucose level J:187860
increased circulating triglyceride level J:187860
increased mean systemic arterial blood pressure J:187860
increased systemic arterial systolic blood pressure J:187860
Nos3tm1Gdk/Nos3tm1Gdk
B6.129P2-Nos3tm1Gdk 		abnormal dopamine level J:64214
abnormal learning/memory/conditioning J:64214
abnormal serotonin level J:64214
abnormal spatial learning J:64214
decreased locomotor activity J:64214
enhanced long-term object recognition memory J:64214
increased anxiety-related response J:64214
Nos3tm1Gdk/Nos3tm1Gdk
involves: 129P2/OlaHsd * C57BL/6 		decreased heart rate J:46061
hypertension J:46061
increased vasoconstriction J:46061
Nos3tm1Plh/Nos3+
involves: 129S4/SvJae * C57BL/6 		abnormal pulmonary alveolus morphology J:83896
Nos3tm1Plh/Nos3tm1Plh
B6.129S4-Nos3tm1Plh 		abnormal cerebral blood flow rate J:107964
abnormal circulating glucose level J:155090
abnormal induced retina neovascularization J:106207
abnormal nervous system physiology J:107964
abnormal seizure response to inducing agent J:107964
abnormal systemic arterial blood pressure J:107964
abnormal vascular endothelial cell physiology J:155090
normal cardiovascular system phenotype J:106207
decreased adiponectin level J:155090
hypertension J:155090
increased circulating triglyceride level J:155090
increased white adipose tissue amount J:155090
Nos3tm1Plh/Nos3tm1Plh
involves: 129S4/SvJae 		abnormal blood flow velocity J:112419
abnormal ejaculation J:59686
abnormal heart right ventricle pressure J:57624, J:100308
abnormal leukocyte adhesion J:55936
abnormal neutrophil physiology J:55936
abnormal penile erection J:89704
abnormal pulmonary pressure J:57624
abnormal pulmonary vascular resistance J:112419
abnormal response/metabolism to endogenous compounds J:112419
abnormal systemic arterial blood pressure J:112419
abnormal systemic vascular resistance J:112419
abnormal vasodilation J:112419
decreased coronary flow rate J:60525
decreased heart rate J:60525, J:100308
decreased neurotransmitter release J:119052
decreased survivor rate J:100308
decreased vasodilation J:28778
enhanced leukocyte tethering or rolling J:55936
hypertension J:28778, J:60525
increased heart rate J:112419
increased mean systemic arterial blood pressure J:55936
increased susceptibility to neuronal excitotoxicity J:111644
increased systemic arterial blood pressure J:57624
increased vasoconstriction J:57624
insulin resistance J:62229
normal muscle phenotype J:56948
normal nervous system phenotype J:37956
premature death J:100308
pulmonary hypertension J:112419
Nos3tm1Plh/Nos3tm1Plh
involves: 129S4/SvJae * C57BL/6 		abnormal adipose tissue amount J:133437
abnormal associative learning J:101302
abnormal blood vessel physiology J:75645, J:108540
abnormal bone mineralization J:67336
abnormal dentate gyrus morphology J:101302
abnormal eye physiology J:66540
abnormal female meiosis J:89702
abnormal femur morphology J:67336
abnormal heart left ventricle morphology J:75645
abnormal hepatocyte morphology J:133437
abnormal induced retina neovascularization J:66540
abnormal liver morphology J:133437
abnormal liver physiology J:133437
abnormal long bone epiphyseal plate morphology J:67336
abnormal lung vasculature morphology J:83896
abnormal myocardial fiber physiology J:75645
abnormal neuron morphology J:101302
abnormal neuronal precursor proliferation J:101302
abnormal oocyte morphology J:89702
abnormal oogenesis J:89702
abnormal osteoblast physiology J:67336
abnormal ovary physiology J:89702
abnormal primary polar body morphology J:89702
abnormal pulmonary alveolus morphology J:83896
abnormal renal glomerulus morphology J:67336
abnormal superovulation J:58361
abnormal trabecular bone thickness J:67336
abnormal vascular wound healing J:119617, J:139343
decreased body weight J:83896
decreased bone mineral density J:67336
decreased cardiac muscle contractility J:75645
decreased circulating glucose level J:133437
decreased circulating insulin level J:133437
decreased litter size J:58361, J:89702
decreased physiological sensitivity to xenobiotic J:108540
decreased prostaglandin level J:108540
decreased superovulation rate J:89702
heart left ventricle hypertrophy J:75645
hepatic steatosis J:133437
normal homeostasis/metabolism phenotype J:133437
increased body weight J:133437
increased cardiac muscle contractility J:75645
increased circulating estradiol level J:89702
increased heart rate J:75645
increased susceptibility to bacterial infection J:105005
increased susceptibility to bacterial infection induced morbidity/mortality J:105005
increased systemic arterial systolic blood pressure J:75645, J:108540
maternal effect J:89702
reduced female fertility J:89702
short estrous cycle J:58361
short femur J:67336
small ovary J:89702
Nos3tm1Plh/Nos3tm1Plh
involves: 129S4/SvJae * C57BL/6J 		decreased ovulation rate J:89542
normal digestive/alimentary phenotype J:64225
increased circulating estradiol level J:89542
increased circulating progesterone level J:89542
prolonged diestrus J:89542
prolonged estrous cycle J:89542
Nos3tm1Unc/Nos3+
B6.129P2-Nos3tm1Unc/J 		postnatal lethality, incomplete penetrance J:103270
Nos3tm1Unc/Nos3+
involves: 129P2/OlaHsd * C57BL/6J 		increased vasodilation J:54772
Nos3tm1Unc/Nos3tm1Unc
B6.129P2-Nos3tm1Unc 		abnormal blood-brain barrier function J:150557
Nos3tm1Unc/Nos3tm1Unc
B6.129P2-Nos3tm1Unc/J 		abnormal angiogenesis J:98913
abnormal circulating protein level J:129477
abnormal glomerular capillary endothelium morphology J:148626
abnormal glomerular capillary thrombosis J:148626
abnormal heart morphology J:103270
abnormal interventricular septum membranous part morphology J:103270
abnormal kidney cortex morphology J:148626
abnormal kidney morphology J:117046
abnormal lung morphology J:98913
abnormal lung vasculature morphology J:98913
abnormal osteoblast physiology J:129477
abnormal osteoclast physiology J:129477
abnormal ovary morphology J:145649
abnormal pregnancy J:145649
abnormal proximal convoluted tubule morphology J:117046
abnormal redox activity J:98094
abnormal renal glomerulus morphology J:117046
abnormal renal tubule epithelium morphology J:148626
abnormal surfactant secretion J:103340
abnormal systemic arterial blood pressure J:148626
abnormal type II pneumocyte morphology J:98913
abnormal vascular branching morphogenesis J:98913
absent alveolar lamellar bodies J:98913
albuminuria J:148626
anovulation J:145649
bicuspid aortic valve J:103340
cardiac hypertrophy J:98094
cyanosis J:98913
decreased bone mineral density J:129477
decreased cardiac muscle contractility J:103270
decreased corpora lutea number J:145649
decreased fertilization frequency J:145649
decreased kidney cell proliferation J:148626
decreased ovulation rate J:145649
decreased vascular endothelial cell number J:148626
dilated renal glomerular capsule J:117046
dilated renal tubule J:148626
enlarged heart J:103270
expanded mesangial matrix J:148626
fetal growth retardation J:98913, J:140819
glomerulosclerosis J:117046, J:148626
impaired embryo implantation J:145649
increased blood urea nitrogen level J:148626
increased bone mineral density J:129477
increased circulating creatine kinase level J:148626
increased circulating osteocalcin level J:129477
increased compact bone thickness J:129477
increased fetal cardiomyocyte apoptosis J:103270
increased heart atrium size J:103270
increased heart left ventricle size J:103270
increased heart right ventricle size J:103270
increased heart ventricle muscle contractility J:98094
increased heart ventricle size J:103270
increased inflammatory response J:103018
increased kidney apoptosis J:148626
increased left ventricle systolic pressure J:98094
increased mesangial cell number J:148626
increased renal tubule apoptosis J:117046
increased susceptibility to induced aneurysm formation J:148626
kidney degeneration J:117046
kidney failure J:148626
kidney inflammation J:148626
lung hemorrhage J:98913
mesangiolysis J:148626
muscular ventricular septal defect J:103270
neonatal lethality, incomplete penetrance J:98913
ostium secundum atrial septal defect J:103270
postnatal lethality, incomplete penetrance J:103270
pulmonary alveolar edema J:103270
pulmonary vascular congestion J:103270
renal cast J:148626
renal glomerulus fibrosis J:148626
renal glomerulus hypertrophy J:148626
renal glomerulus lipidosis J:117046
renal hypoplasia J:117046
renal interstitial fibrosis J:117046, J:148626
renal tubular necrosis J:117046
respiratory distress J:98913
small ovary J:145649
thick pulmonary interalveolar septum J:98913
ventricular septal defect J:103270
Nos3tm1Unc/Nos3tm1Unc
BKS.129P2-Nos3tm1Unc 		albuminuria J:135864
increased systemic arterial systolic blood pressure J:135864
Nos3tm1Unc/Nos3tm1Unc
involves: 129P2/OlaHsd 		abnormal blood homeostasis J:103153
abnormal glucose homeostasis J:103153
abnormal heart morphology J:102136
abnormal interventricular septum morphology J:102136
abnormal systemic arterial blood pressure J:102136
cardiac hypertrophy J:102136
decreased body weight J:102136
decreased cardiac muscle contractility J:102136
decreased heart left ventricle posterior wall thickness J:102136
decreased vasodilation J:103153
dilated heart left ventricle J:102136
hyperlipidemia J:103153
hypertension J:102136, J:103153
increased circulating cholesterol level J:103153
increased circulating free fatty acids level J:103153
increased circulating insulin level J:103153
increased circulating triglyceride level J:103153
increased heart rate J:102136
increased heart weight J:102136
increased systemic arterial blood pressure J:102136
increased systemic arterial diastolic blood pressure J:102136
increased systemic arterial systolic blood pressure J:102136
insulin resistance J:103153
premature death J:102136
Nos3tm1Unc/Nos3tm1Unc
involves: 129P2/OlaHsd * C57BL/6 		abnormal cardiovascular system morphology J:101254
abnormal cardiovascular system physiology J:101254
abnormal heart right ventricle pressure J:101254
abnormal heart weight J:101254
abnormal pulmonary artery morphology J:101254
decreased body temperature J:113106
decreased body weight J:36559, J:101254
decreased heart rate J:36559
decreased susceptibility to induced morbidity/mortality J:113106
decreased vascular permeability J:113106
normal immune system phenotype J:36559
increased circulating renin level J:36559
increased mean systemic arterial blood pressure J:101254
increased systemic arterial blood pressure J:36559
Nos3tm1Unc/Nos3tm1Unc
involves: 129P2/OlaHsd * C57BL/6J 		abnormal vasodilation J:54772
decreased body weight J:36559
decreased heart rate J:36559, J:54772
normal homeostasis/metabolism phenotype J:64896
hypertension J:54772
increased circulating renin level J:36559
increased systemic arterial blood pressure J:36559
increased vasoconstriction J:54772
Nos3tm1Weo/Nos3tm1Weo
B6.129S7-Nos3tm1Weo 		abnormal fertility/fecundity J:89703
abnormal superovulation J:89703
decreased superovulation rate J:73964, J:89703
delayed female fertility J:89703
early reproductive senescence J:89703
impaired fertilization J:73964
Nos3tm1Weo/Nos3tm1Weo
involves: 129 		normal reproductive system phenotype J:73964
Nos3tm1Weo/Nos3tm1Weo
involves: 129S7/SvEvBrd * C57BL/6 		abnormal cardiac muscle relaxation J:51563
abnormal limb morphology J:51563
postnatal lethality, incomplete penetrance J:51563
short limbs J:51563
syndactyly J:51563
Nos3tm2.1Plh/Nos3tm2.1Plh
involves: 129S4/SvJae * C57BL/6 		decreased adiponectin level J:198075
decreased circulating insulin level J:198075
decreased vasodilation J:198075
increased brown adipose tissue amount J:198075
increased circulating free fatty acids level J:198075
increased circulating LDL cholesterol level J:198075
increased circulating leptin level J:198075
increased inguinal fat pad weight J:198075
increased liver weight J:198075
increased mean systemic arterial blood pressure J:198075
increased retroperitoneal fat pad weight J:198075
increased susceptibility to weight gain J:198075
increased white fat cell size J:198075
insulin resistance J:198075
Nos3tm3.1Plh/Nos3tm3.1Plh
involves: 129S4/SvJae * C57BL/6 		decreased white fat cell size J:198075
improved glucose tolerance J:198075
increased circulating glucose level J:198075
increased circulating insulin level J:198075
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/17/2024
MGI 6.24 		The Jackson Laboratory