Nos3 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Nos3
nitric oxide synthase 3, endothelial cell
MGI:97362

88 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Apoe^tm1Unc/Apoe^tm1Unc Nos3^tm1Plh/Nos3^tm1Plh B6.129-Nos3^tm1Plh Apoe^tm1Unc	aortic dissection	J:103306
	cardiac fibrosis	J:103306
	decreased cardiac muscle contractility	J:103306
	dilated heart left ventricle	J:103306
	increased heart left ventricle posterior wall thickness	J:103306
	increased mean systemic arterial blood pressure	J:103306
	increased susceptibility to atherosclerosis	J:103306
	increased susceptibility to induced aneurysm formation	J:103306
	thick interventricular septum	J:103306
Apoe^tm1Unc/Apoe^tm1Unc Nos3^tm1Unc/Nos3^tm1Unc B6.129P2-Nos3^tm1Unc Apoe^tm1Unc	abnormal cardiovascular system morphology	J:60670
	abnormal renal glomerulus morphology	J:60670
	aortic sinus aneurysm	J:60670
	atherosclerotic lesions	J:60670
	decreased kidney weight	J:60670
	increased circulating creatinine level	J:60670
	increased susceptibility to atherosclerosis	J:60670
	increased systemic arterial systolic blood pressure	J:60670
Asl^tm1Brle/Asl⁺ Nos3^tm1Weo/Nos3⁺ involves: 129S7/SvEvBrd	decreased systemic arterial diastolic blood pressure	J:180208
Asl^tm1Brle/Asl⁺ Nos3^tm1Weo/Nos3⁺ involves: 129S7/SvEvBrd	decreased systemic arterial systolic blood pressure	J:180208
Lepr^db/Lepr^db Nos3^tm1Unc/Nos3^tm1Unc BKS.Cg-Lepr^db Nos3^tm1Unc	abnormal kidney afferent arteriole morphology	J:135864
	abnormal nephron morphology	J:135864
	abnormal renal glomerulus morphology	J:135864
	albuminuria	J:135864
	decreased renal glomerular filtration rate	J:135864
	expanded mesangial matrix	J:135864
	glomerulosclerosis	J:135864
	hyperglycemia	J:135864
	increased body weight	J:135864
	increased circulating creatinine level	J:135864
	increased renal glomerulus basement membrane thickness	J:135864
	increased systemic arterial systolic blood pressure	J:135864
	mesangiolysis	J:135864
	renal glomerulus fibrosis	J:135864
Nos1^tm1Plh/Nos1^tm1Plh Nos2^tm1Mrl/Nos2^tm1Mrl Nos3^tm1Plh/Nos3^tm1Plh involves: 129S4/SvJae * 129S7/SvEvBrd	abnormal bone mineralization	J:150159
	abnormal bone structure	J:150159
	abnormal coronary artery morphology	J:100308
	abnormal glomerular capillary thrombosis	J:100308
	abnormal kidney physiology	J:100308
	abnormal nitric oxide homeostasis	J:100308
	abnormal osteoclast physiology	J:150159
	abnormal renal glomerulus morphology	J:100308
	abnormal skeleton physiology	J:150159
	abnormal trabecular bone morphology	J:150159
	congestive heart failure	J:100308
	decreased heart rate	J:100308
	decreased survivor rate	J:100308
	decreased urine osmolality	J:100308
	decreased urine sodium level	J:100308
	dehydration	J:100308
	enlarged stomach	J:100308
	glomerulosclerosis	J:100308
	hypertension	J:100308
	increased blood osmolality	J:100308
	increased blood urea nitrogen level	J:100308
	increased bone mineral density	J:150159
	increased circulating alkaline phosphatase level	J:150159
	increased circulating creatinine level	J:100308
	increased osteoclast cell number	J:150159
	increased prostaglandin level	J:100308
	increased renal tubule apoptosis	J:100308
	increased systemic arterial blood pressure	J:100308
	increased systemic arterial systolic blood pressure	J:100308
	liver vascular congestion	J:100308
	polydipsia	J:100308
	polyuria	J:100308
	premature death	J:100308
	pulmonary vascular congestion	J:100308
	pyloric sphincter hypertrophy	J:100308
	reduced fertility	J:100308
	renal tubular necrosis	J:100308
	visceral vascular congestion	J:100308
Nos1^tm1Plh/Nos1^tm1Plh Nos2^tm1Mrl/Nos2^tm1Mrl Nos3^tm1Plh/Nos3^tm1Plh involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6	abnormal cardiovascular system morphology	J:155090
	abnormal cardiovascular system physiology	J:155090
	abnormal circulating glucose level	J:155090
	abnormal vascular endothelial cell physiology	J:155090
	abnormal vascular wound healing	J:155090
	arteriosclerosis	J:155090
	decreased adiponectin level	J:155090
	hypertension	J:155090
	increased circulating LDL cholesterol level	J:155090
	increased circulating triglyceride level	J:155090
	increased white adipose tissue amount	J:155090
	perivascular fibrosis	J:155090
	premature death	J:155090
	thick ventricular wall	J:155090
Nos1^tm1Plh/Nos1^tm1Plh Nos3^tm1Plh/Nos3^tm1Plh B6.129S4-Nos3^tm1Plh Nos1^tm1Plh	abnormal cardiac muscle relaxation	J:129064
	cardiac interstitial fibrosis	J:129064
	decreased left ventricle diastolic pressure	J:129064
	heart left ventricle hypertrophy	J:129064
	increased cardiac muscle contractility	J:129064
	increased heart rate	J:129064
	increased systemic arterial systolic blood pressure	J:129064
Nos1^tm1Plh/Nos1^tm1Plh Nos3^tm1Plh/Nos3^tm1Plh involves: 129S4/SvJae	abnormal sensory neuron innervation pattern	J:61144
	decreased heart rate	J:100308
	decreased survivor rate	J:100308
	decreased urine osmolality	J:100308
	decreased urine sodium level	J:100308
	increased blood osmolality	J:100308
	increased blood urea nitrogen level	J:100308
	increased systemic arterial systolic blood pressure	J:100308
	normal nervous system phenotype	J:37956
	polydipsia	J:100308
	polyuria	J:100308
	premature death	J:100308
	reduced fertility	J:100308
	reduced long-term potentiation	J:37956
Nos1^tm1Plh/Nos1^tm1Plh Nos3^tm1Plh/Nos3^tm1Plh involves: 129S4/SvJae * C57BL/6	abnormal cardiac muscle relaxation	J:75645
	decreased cardiac muscle contractility	J:75645
	decreased survivor rate	J:129064
	heart left ventricle hypertrophy	J:75645
	increased cardiac muscle contractility	J:75645
	increased heart rate	J:75645
	increased systemic arterial systolic blood pressure	J:75645
	premature death	J:129064
Nos1^tm1Plh/Nos1^tm1Plh Nos3^tm1Unc/Nos3^tm1Unc involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J	prenatal lethality, incomplete penetrance	J:83112
Nos2^tm1Lau/Nos2^tm1Lau Nos3^tm1Unc/Nos3^tm1Unc B6.129P2-Nos3^tm1Unc Nos2^tm1Lau	prenatal lethality, incomplete penetrance	J:83112
Nos2^tm1Mrl/Nos2^tm1Mrl Nos3^tm1Plh/Nos3^tm1Plh involves: 129S4/SvJae * 129S7/SvEvBrd	decreased heart rate	J:100308
	decreased survivor rate	J:100308
	decreased urine osmolality	J:100308
	decreased urine sodium level	J:100308
	increased blood osmolality	J:100308
	increased blood urea nitrogen level	J:100308
	increased systemic arterial systolic blood pressure	J:100308
	polydipsia	J:100308
	polyuria	J:100308
	premature death	J:100308
	reduced fertility	J:100308
Nos3^tm1Plh/Nos3^tm1Plh Ptgs1^tm1Unc/Ptgs1^tm1Unc involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6	abnormal blood vessel physiology	J:108540
	decreased physiological sensitivity to xenobiotic	J:108540
	decreased prostaglandin level	J:108540
	increased systemic arterial systolic blood pressure	J:108540
Nos3^tm1Plh/Nos3^tm1Plh Tg(RHO-VEGFA)V-6Camp/0 involves: 129S4/SvJae * C57BL/6J	abnormal angiogenesis	J:106207

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24