About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Notch1
notch 1
MGI:97363
175 phenotypes from 23 alleles in 39 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Albtm1(cre/ERT2)Mtz/Alb+
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 		increased cholangiocarcinoma incidence J:192740
Cpa3tm3(icre)Hrr/Cpa3+
Notch1tm1Agt/Notch1tm1Agt
involves: 129 * C57BL/6 		abnormal B cell differentiation J:143731
abnormal B cell morphology J:143731
abnormal T cell receptor beta chain V(D)J recombination J:143731
decreased double-negative T cell number J:143731
decreased double-positive T cell number J:143731
increased single-positive T cell number J:143731
thymus hypoplasia J:143731
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Tg(Mx1-cre)1Cgn/0
involves: 129S4/SvJaeSor * C57BL/6 * CBA 		decreased B cell number J:167000
enlarged spleen J:167000
increased leukemia incidence J:167000
increased leukocyte cell number J:167000
premature death J:167000
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Tg(Pdx1-cre)89.1Dam/0
involves: 129S4/SvJae * C57BL/6 * ICR 		abnormal endocrine pancreas morphology J:86975
abnormal exocrine pancreas morphology J:86975
abnormal pancreas development J:86975
decreased pancreatic alpha cell number J:86975
decreased pancreatic beta cell number J:86975
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Tg(Pdx1-cre)89.1Dam/0
involves: 129S4/SvJaeSor * C57BL/6 * CBA 		abnormal pancreas development J:169830
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Tg(Pdx1-cre/Esr1*)35.10Dam/0
involves: 129S4/SvJae * C57BL/6 * CBA 		abnormal pancreas development J:86975
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Tg(Neurog3-cre/Esr1*)1Dam/0
involves: 129S4/SvJae * C57BL/6 * CBA 		absent pancreatic alpha cells J:86975
embryonic lethality during organogenesis, complete penetrance J:86975
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Tg(Col1a1-cre)1Kry/0
involves: 129S4/SvJaeSor * C57BL/6 * FVB/N 		abnormal bone marrow cavity morphology J:233131
abnormal skeleton morphology J:233131
abnormal trabecular bone morphology J:233131
decreased body weight J:233131
decreased bone trabecular spacing J:233131
increased bone mass J:233131
increased bone trabecula number J:233131
increased trabecular bone thickness J:233131
increased trabecular bone volume J:233131
kinked tail J:233131
osteosclerosis J:233131
postnatal growth retardation J:233131
thick neurocranium J:233131
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Tg(Neurog3-cre)C1Able/0
involves: 129S4/SvJaeSor 		abnormal pancreas development J:190530
abnormal pancreatic duct morphology J:190530
absent pancreatic islets J:190530
decreased body weight J:190530
normal endocrine/exocrine gland phenotype J:190530
hyperglycemia J:190530
postnatal lethality, complete penetrance J:190530
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Shhtm2(cre/ERT2)Cjt/Shh+
involves: 129S4/SvJaeSor * 129S6/SvEvTac 		normal vision/eye phenotype J:118372
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
involves: 129S4/SvJaeSor * C57BL/6J 		abnormal renal tubule morphology J:185844
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Hes1tm1(cre/ERT2)Lcm/Hes1+
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ 		abnormal pancreas development J:169830
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Tg(Adipoq-cre)1Evdr/0
involves: 129S4/SvJaeSor * C57BL/6J * FVB/NJ 		abnormal white fat cell differentation J:237232
absent epididymal fat pad J:237232
decreased susceptibility to diet-induced obesity J:237232
hepatic steatosis J:237232
hyperglycemia J:237232
increased circulating insulin level J:237232
increased liposarcoma incidence J:237232
increased liver weight J:237232
insulin resistance J:237232
lipodystrophy J:237232
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Tg(Wt1-cre)#Jbeb/0
involves: 129S4/SvJaeSor 		abnormal epicardium morphology J:178290
hemopericardium J:178290
lethality throughout fetal growth and development J:178290
thin myocardium compact layer J:178290
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Tg(Neurod1-cre)1Able/0
involves: 129S4/SvJaeSor * C57BL/6 * DBA/2 		abnormal pancreas morphology J:190530
abnormal pancreatic islet morphology J:190530
normal homeostasis/metabolism phenotype J:190530
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Tg(Neurog3-cre/ERT2)1Able/0
involves: 129S4/SvJaeSor * C57BL/6 * DBA/2 		normal endocrine/exocrine gland phenotype J:190530
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sortm1(Notch1)Dam
involves: 129S4/SvJae * C57BL/6 		no abnormal phenotype detected J:86975
Notch1sot/Notch1sot
involves: 129S1/Sv * C57BL/6 * FVB/NJ 		abnormal nervous system development J:171522
abnormal trigeminal ganglion morphology J:171522
abnormal vascular development J:171522
decreased embryo size J:171522
embryonic lethality during organogenesis, complete penetrance J:171522
small pharyngeal arch J:171522
Notch1tm1.1(cre/ERT2)Sat/Notch1+
C57BL/6-Notch1tm1.1(cre/ERT2)Sat 		no abnormal phenotype detected J:179632
Notch1tm1.1(cre/ERT2)Sat/Notch1tm1.1(cre/ERT2)Sat
C57BL/6-Notch1tm1.1(cre/ERT2)Sat 		embryonic lethality J:179632
Notch1tm1Agt/Notch1tm1Agt
involves: 129 		no abnormal phenotype detected J:55400
Notch1tm1Agt/Notch1tm1Agt
Tg(Mx1-cre)1Cgn/0
involves: 129 * C57BL/6 * CBA 		abnormal B cell differentiation J:125373
abnormal T cell differentiation J:55400, J:125373
abnormal thymus cell ratio J:55400, J:143472
abnormal thymus morphology J:55400
decreased body weight J:55400
decreased CD4-positive, alpha-beta T cell number J:55400
decreased CD8-positive, alpha-beta T cell number J:55400
decreased double-negative T cell number J:55400
decreased double-positive T cell number J:55400
decreased single-positive T cell number J:55400
decreased thymocyte number J:55400
normal hematopoietic system phenotype J:98129
increased immature B cell number J:143472
postnatal growth retardation J:55400
premature death J:55400
small thymus J:55400
Notch1tm1Agt/Notch1tm1Agt
Tg(Tek-cre)1Ywa/0
involves: 129 * C57BL/6 * SJL 		abnormal angiogenesis J:100449
abnormal anterior cardinal vein morphology J:100449
abnormal intersomitic vessel morphology J:100449
abnormal placental labyrinth vasculature morphology J:100449
abnormal somite development J:100449
abnormal vascular branching morphogenesis J:100449
abnormal vitelline vascular remodeling J:100449
delayed heart looping J:100449
embryonic growth arrest J:100449
embryonic growth retardation J:100449
embryonic lethality during organogenesis, complete penetrance J:100449
hemopericardium J:100449
hemorrhage J:100449
incomplete embryo turning J:100449
increased apoptosis J:100449
neural tube degeneration J:100449
pericardial effusion J:100449
thin myocardium J:100449
Notch1tm1Agt/Notch1tm1Agt
Tg(Tek-cre)12Flv/0
involves: 129 * C3H * C57BL/6 		abnormal angiogenesis J:100449
abnormal anterior cardinal vein morphology J:100449
abnormal intersomitic vessel morphology J:100449
abnormal placental labyrinth vasculature morphology J:100449
abnormal somite development J:100449
abnormal vascular branching morphogenesis J:100449
abnormal vitelline vascular remodeling J:100449
delayed heart looping J:100449
embryonic growth arrest J:100449
embryonic growth retardation J:100449
embryonic lethality during organogenesis, complete penetrance J:100449
hemopericardium J:100449
hemorrhage J:100449
incomplete embryo turning J:100449
increased apoptosis J:100449
neural tube degeneration J:100449
pericardial effusion J:100449
thin myocardium J:100449
Notch1tm1Agt/Notch1tm1Agt
Tg(Tyr-cre)2Lru/0
involves: 129 * BALB/c * C57BL/6 * DBA/2 		diluted coat color J:116658
Notch1tm1Agt/Notch1tm1Agt
Tg(Wt1-cre)#Jbeb/0
involves: 129 		abnormal coronary vessel morphology J:178290
absent coronary vessels J:178290
embryonic lethality during organogenesis J:178290
hemopericardium J:178290
hemorrhage J:178290
myocardium hypoplasia J:178290
thin myocardium compact layer J:178290
Notch1tm1b(EUCOMM)Hmgu/Notch1+
C57BL/6N-Notch1tm1b(EUCOMM)Hmgu/H 		abnormal vertebrae morphology J:211773
increased grip strength J:211773
increased startle reflex J:211773
Notch1tm1b(EUCOMM)Hmgu/Notch1tm1b(EUCOMM)Hmgu
C57BL/6N-Notch1tm1b(EUCOMM)Hmgu/H 		preweaning lethality, complete penetrance J:211773
Notch1tm1Con/Notch1+
involves: 129S1/Sv * 129X1/SvJ 		abnormal retina vasculature morphology J:254752
Notch1tm1Con/Notch1+
involves: 129S1/Sv * 129X1/SvJ * CD-1 		aortic valve inflammation J:187551
calcified aortic valve cusp J:187551
normal cardiovascular system phenotype J:187551
thick aortic valve cusps J:187551
Notch1tm1Con/Notch1tm1Con
either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1) 		abnormal cell death J:25248
abnormal left-right axis symmetry of the somites J:25248
abnormal rostral-caudal axis patterning J:25248
abnormal somite development J:25248, J:62882
abnormal somite size J:25248
decreased embryo size J:25248
delayed somite formation J:25248
distended pericardium J:25248, J:62882
embryonic growth arrest J:25248, J:62882
embryonic lethality during organogenesis, complete penetrance J:25248
kinked neural tube J:62882
notochord degeneration J:25248
Notch1tm1Con/Notch1tm1Con
involves: 129S1/Sv * 129X1/SvJ 		abnormal myocardium layer morphology J:119151
disorganized myocardium J:119151
trabecula carnea hypoplasia J:119151
Notch1tm1Con/Notch1tm1Grid
Tg(Pax2-cre)1Akg/0
involves: 129S1/Sv * 129X1/SvJ 		abnormal vascular development J:119907
embryonic lethality during organogenesis, complete penetrance J:119907
internal hemorrhage J:119907
normal renal/urinary system phenotype J:119907
Notch1tm1Grid/Notch1+
involves: 129S1/Sv * C57BL/6 		abnormal retina blood vessel morphology J:227333
increased cochlear outer hair cell number J:62727
Notch1tm1Grid/Notch1tm1Grid
involves: 129S1/Sv * C57BL/6 		abnormal dorsal aorta morphology J:62571
abnormal placenta vasculature J:62571
absent vitelline blood vessels J:62571
decreased angiogenesis J:62571
embryonic growth retardation J:17509
embryonic lethality during organogenesis, complete penetrance J:17509
pale yolk sac J:62571
Notch1tm1Grid/Notch1tm2Rko
Foxg1tm1(cre)Skm/Foxg1+
involves: 129 * C57BL/6J * Swiss Webster 		decreased organ of Corti supporting cell number J:132241
increased cochlear inner hair cell number J:132241
Notch1tm1Pst/Notch1tm1Pst
involves: 129/Sv * C57BL/6 * SJL 		abnormal embryonic tissue morphology J:112097
embryonic growth retardation J:112097
embryonic lethality during organogenesis, complete penetrance J:112097
Notch1tm1Rko/Notch1tm1Rko
involves: 129X1/SvJ 		abnormal rostral-caudal axis patterning J:62882
abnormal somite development J:62882
absent vitelline blood vessels J:62882
distended pericardium J:62882
embryonic growth arrest J:62882
embryonic growth retardation J:62882
embryonic lethality, complete penetrance J:62882
kinked neural tube J:62882
Notch1tm2.1Rko/Notch1+
Not Specified 		abnormal vertebrae morphology J:186213
Notch1tm2Agt/Notch1tm2Agt
involves: 129 		abnormal artery morphology J:89444
abnormal cardiac epithelial to mesenchymal transition J:133699
Notch1tm2Agt/Notch1tm2Agt
involves: 129/Sv * C57BL/6 		embryonic lethality during organogenesis, complete penetrance J:55400
Notch1tm2Pst/Notch1tm2.1Pst
B6.Cg-Notch1tm2.1Pst 		embryonic growth retardation J:131563
embryonic lethality during organogenesis, complete penetrance J:131563
Notch1tm2Pst/Notch1tm2.1Pst
involves: 129/Sv * C57BL/6 * SJL 		abnormal embryonic neuroepithelium morphology J:131563
abnormal heart development J:131563
abnormal vasculogenesis J:131563
anemia J:131563
decreased embryo size J:131563
embryonic growth retardation J:131563
embryonic lethality during organogenesis, complete penetrance J:131563
Notch1tm2Pst/Notch1tm2Pst
B6.Cg-Notch1tm2Pst 		abnormal T cell differentiation J:131563
decreased double-negative T cell number J:131563
decreased T cell number J:131563
decreased thymocyte number J:131563
increased T cell apoptosis J:131563
postnatal growth retardation J:131563
Notch1tm2Rko/Notch1tm2Rko
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129X1/SvJ * C57BL/6 * CBA 		normal craniofacial phenotype J:181120
perinatal lethality, complete penetrance J:181120
Notch1tm2Rko/Notch1tm2Rko
Tg(KRT14-rtTA)F42Efu/0
Tg(tetO-cre)1Jaw/0
involves: 129 * 129X1/SvJ * C57BL/6 * FVB/N 		alopecia J:194073
decreased conjunctiva goblet cell number J:194073
dry eyes J:194073
lacrimal gland degeneration J:194073
Meibomian gland degeneration J:194073
Notch1tm2Rko/Notch1tm2Rko
Tg(Msx2-cre)5Rem/0
Not Specified 		abnormal hair follicle morphology J:94517
abnormal hair growth J:94517
abnormal hair shaft morphology J:94517
disorganized inner root sheath cells J:94517
short hair J:94517
small sebaceous gland J:94517
waved hair J:94517
Notch1tm2Rko/Notch1tm2Rko
Tg(Nes-cre)1Kln/0
involves: 129X1/SvJ * C57BL/6J * SJL 		abnormal apoptosis J:90392
increased neuron number J:90392
Notch1tm2Rko/Notch1tm3(cre)Rko
involves: 129X1/SvJ * C57BL/6 		abnormal cornea morphology J:171829
abnormal hepatic cord morphology J:171829
abnormal liver lobule morphology J:171829
abnormal liver morphology J:171829
abnormal liver parenchyma morphology J:171829
abnormal spleen morphology J:171829
chronic liver inflammation J:171829
cornea deposits J:171829
cornea vascularization J:171829
dilated liver sinusoidal space J:171829
enlarged spleen J:171829
extramedullary hematopoiesis J:171829
hemoperitoneum J:171829
increased angiogenesis J:171829
increased hemangioma incidence J:171829
pale liver J:171829
premature death J:171829
Notch1tm2Rko/Notch1tm4(cre)Rko
involves: 129X1/SvJ * C57BL/6 		abnormal vitelline vasculature morphology J:171829
embryonic lethality during organogenesis, complete penetrance J:171829
Notch1tm3(cre)Rko/Notch1tm3(cre)Rko
involves: 129X1/SvJ * C57BL/6J * SJL 		embryonic lethality during organogenesis, complete penetrance J:119910
Notch1tm5(cre/ERT2)Rko/Notch1tm5(cre/ERT2)Rko
involves: C57BL/6NTac 		embryonic lethality during organogenesis J:101977
Tg(LckNotch1)9Erob/?
involves: C57BL/6 * CBA/J 		abnormal CD8-positive, alpha-beta T cell differentiation J:93005
abnormal thymus cell ratio J:93005
decreased CD4-positive, alpha-beta T cell number J:93005
increased CD8-positive, alpha-beta T cell number J:93005
increased T cell derived lymphoma incidence J:93005
Tg(Notch1)1Anc/0
Not Specified 		curly vibrissae J:65042
focal hair loss J:65042
short vibrissae J:65042
waved hair J:65042
Tg(Notch1)A3Rko/0
involves: FVB/N 		no abnormal phenotype detected J:62217
Tg(Notch1)A4Rko/0
involves: FVB/N 		no abnormal phenotype detected J:62217
Tg(Notch1)A5Rko/0
involves: FVB/N 		alopecia J:62217
curly vibrissae J:62217
decreased curvature of zigzag hairs J:62217
deformed nails J:62217
waved hair J:62217
Tg(Notch1)A7Rko/0
involves: FVB/N 		alopecia J:62217
curly vibrissae J:62217
decreased curvature of zigzag hairs J:62217
deformed nails J:62217
waved hair J:62217
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory