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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Notch2
notch 2
MGI:97364
60 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Jag1tm1.1Loo/Jag1+
Notch2tm1Grid/Notch2+
Tg(Alb1-cre)1Khk/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		no abnormal phenotype detected J:149131
Jag1tm1Grid/Jag1+
Notch2tm1Grid/Notch2+
involves: 129S1/Sv 		abnormal bile duct development J:133171
abnormal bile duct morphology J:133171
Jag1tm1Grid/Jag1+
Notch2tm1Grid/Notch2+
involves: 129S1/Sv * C57BL/6J 		abnormal anterior eye segment morphology J:74574
abnormal bile duct development J:74574
abnormal glomerular capillary morphology J:67157
abnormal liver morphology J:74574
atrial septal defect J:74574
cholestasis J:74574
decreased renal glomerulus number J:74574
increased blood urea nitrogen level J:74574
increased circulating alanine transaminase level J:74574
increased circulating alkaline phosphatase level J:74574
jaundice J:74574
kidney microaneurysm J:74574
overriding aortic valve J:74574
postnatal growth retardation J:74574
postnatal lethality, incomplete penetrance J:74574
pulmonary artery stenosis J:74574
small kidney J:67157
ventricular hypoplasia J:74574
ventricular septal defect J:74574
Jag1tm1Grid/Jag1+
Notch2tm3.1Grid/Notch2+
B6.129S1-Jag1tm1Grid Notch2tm3.1Grid 		abnormal bile duct morphology J:171432
abnormal biliary tract morphology J:171432
Notch1tm1Agt/Notch1+
Notch2tm1Frad/Notch2+
Tg(Tyr-cre)2Lru/0
involves: 129 * BALB/c * C57BL/6 * DBA/2 		diluted coat color J:116658
Notch1tm1Agt/Notch1+
Notch2tm1Frad/Notch2tm1Frad
Tg(Tyr-cre)2Lru/0
involves: 129 * BALB/c * C57BL/6 * DBA/2 		abnormal hair follicle melanocyte morphology J:116658
diluted coat color J:116658
normal pigmentation phenotype J:116658
Notch1tm1Agt/Notch1tm1Agt
Notch2tm1Frad/Notch2+
Tg(Tyr-cre)2Lru/0
involves: 129/Sv * BALB/c * C57BL/6 * DBA/2 		diluted coat color J:116658
normal pigmentation phenotype J:116658
Notch1tm1Agt/Notch1tm1Agt
Notch2tm1Frad/Notch2tm1Frad
Ptf1atm1(cre)Hnak/Ptf1a+
involves: 129 * BALB/cJ 		abnormal branching involved in pancreas development J:139250
abnormal endocrine pancreas morphology J:139250
abnormal pancreas development J:139250
abnormal pancreatic acinus morphology J:139250
abnormal pancreatic bud formation J:139250
decreased pancreatic islet number J:139250
small pancreas J:139250
Notch1tm1Agt/Notch1tm1Agt
Notch2tm1Frad/Notch2tm1Frad
Tg(Mx1-cre)1Cgn/0
involves: 129 * BALB/c * C57BL/6 * CBA 		abnormal T cell differentiation J:125373
arrested T cell differentiation J:125373
Notch1tm1Agt/Notch1tm1Agt
Notch2tm1Frad/Notch2tm1Frad
Tg(Tyr-cre)2Lru/0
involves: 129 * BALB/c * C57BL/6 * DBA/2 		diluted coat color J:116658
Notch1tm1Agt/Notch1tm1Agt
Notch2tm3Grid/Notch2tm3Grid
Tg(TcrAND)53Hed/?
involves: 129/Sv * 129S1/Sv * C57BL/6 * SJL 		abnormal humoral immune response J:123631
abnormal response to infection J:123631
decreased interleukin-4 secretion J:123631
Notch1tm1Con/Notch1+
Notch2tm3.1Rko/Notch2tm3.1Grid
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		normal renal/urinary system phenotype J:198632
Notch1tm1Grid/Notch1tm1Grid
Notch2tm1Grid/Notch2tm1Grid
involves: 129S1/Sv * C57BL/6J 		abnormal direction of heart looping J:83358
abnormal left-right axis patterning J:83358
Notch1tm2Rko/Notch1tm2Rko
Notch2tm1Rko/Notch2tm1Rko
Notch3Gt(PST033)Byg/Notch3+
Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * CBA 		abnormal spleen morphology J:172442
enlarged spleen J:172442
extramedullary hematopoiesis J:172442
increased hematopoietic cell number J:172442
increased spleen red pulp amount J:172442
Notch1tm2Rko/Notch1tm2Rko
Notch2tm1Rko/Notch2tm1Rko
Notch3Gt(PST033)Byg/Notch3Gt(PST033)Byg
Tg(Msx2-cre)5Rem/0
involves: 129P2/OlaHsd * 129X1/SvJ 		absent sebaceous gland J:94517
scaly skin J:94517
thick epidermis J:94517
Notch1tm2Rko/Notch1tm2Rko
Notch2tm1Rko/Notch2tm1Rko
Notch3Gt(PST033)Byg/Notch3Gt(PST033)Byg
Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * CBA 		abnormal definitive hematopoiesis J:172442
abnormal spleen morphology J:172442
enlarged spleen J:172442
extramedullary hematopoiesis J:172442
increased hematopoietic cell number J:172442
increased leukemia incidence J:172442
increased spleen red pulp amount J:172442
Notch1tm2Rko/Notch1tm2Rko
Notch2tm1Rko/Notch2tm1Rko
Tg(Msx2-cre)5Rem/0
involves: 129X1/SvJ * C57BL/6 * CBA 		absent hair follicle inner root sheath J:94517
absent sebaceous gland J:94517
epidermal hyperplasia J:94517
hair follicle degeneration J:94517
premature death J:94517
progressive hair loss J:94517
scaly skin J:94517
Notch1tm6.1Rko/Notch1+
Notch2tm3Grid/Notch2tm3Grid
Tg(Pax3-cre)1Joe/0
involves: 129S1/Sv * C57BL/6 * SJL 		renal hypoplasia J:198632
Notch1tm6.1Rko/Notch1tm6.1Rko
Notch2tm3Grid/Notch2tm3Grid
Tg(Pax3-cre)1Joe/0
involves: 129S1/Sv * C57BL/6 * SJL 		neonatal lethality, complete penetrance J:198632
renal hypoplasia J:198632
Notch2Gt(LST103)Byg/Notch2+
Notch3Gt(PST033)Byg/Notch3Gt(PST033)Byg
involves: 129P2/OlaHsd 		abnormal lung development J:155893
impaired lung alveolus development J:155893
neonatal lethality, complete penetrance J:155893
Notch2tm1Bmc/Notch2tm1Bmc
involves: 129S1/Sv * C57BL/6 		no abnormal phenotype detected J:107000
Notch2tm1Grid/Notch2+
Dll1tm1Gos/Dll1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		normal renal/urinary system phenotype J:67157
Notch2tm3.1Grid/Notch2+
Poglut1Gt(IST10323G11)Tigm/Poglut1+
B6.Cg-Notch2tm3.1Grid Poglut1Gt(IST10323G11)Tigm 		normal liver/biliary system phenotype J:171432
Notch2tm3.1Rko/Notch2tm3.1Rko
involves: C57BL/6 		normal renal/urinary system phenotype J:198632
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory