Pnp Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pnp
purine-nucleoside phosphorylase
MGI:97365

36 phenotypes from 9 alleles in 9 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Pnp^bata/Pnp^bata C57BL/6JSfdAnu-Pnp^bata	decreased B cell proliferation	J:104190
	decreased marginal zone B cell number	J:104190
	increased T follicular helper cell number	J:104190
Pnp^e/Pnp^e C57BL/6J-Pnp^e	abnormal leukocyte physiology	J:39328
Pnp^e/Pnp^e C57BL/6J-Pnp^e	thymus hypoplasia	J:39328
Pnp^e/Pnp^e involves: C3H/HeHa * C57BL/6J	abnormal urine nucleotide level	J:23354
Pnp^e/Pnp^e involves: C3H/HeHa * C57BL/6J	decreased purine-nucleoside phosphorylase activity	J:23354
Pnp^f/Pnp^f C57BL/6J-Pnp^f	abnormal leukocyte cell number	J:39328
	abnormal leukocyte physiology	J:39328
	decreased CD8-positive, alpha-beta T cell number	J:39328
	decreased double-positive T cell number	J:39328
	thymus hypoplasia	J:39328
Pnp^f/Pnp^f involves: C3H/HeHa * C57BL/6J	abnormal urine nucleotide level	J:23354
	decreased purine-nucleoside phosphorylase activity	J:23354
	increased double-negative T cell number	J:522
Pnp^g/Pnp^g involves: C57BL/6 * DBA/2J	abnormal leukocyte cell number	J:39328
	abnormal leukocyte physiology	J:39328
	decreased CD8-positive, alpha-beta T cell number	J:39328
	decreased double-positive T cell number	J:39328
	decreased purine-nucleoside phosphorylase activity	J:522
	increased double-negative T cell number	J:39328
	prenatal lethality, incomplete penetrance	J:523
	thymus hypoplasia	J:39328
Pnp^g/Pnp^g involves: C57BL/6J	embryonic lethality during organogenesis, complete penetrance	J:523
Pnp^h/Pnp^h involves: C3H/HeHa * C57BL/6J	decreased purine-nucleoside phosphorylase activity	J:522
Pnpⁱ/Pnpⁱ involves: C3H/HeHa * C57BL/6J	decreased purine-nucleoside phosphorylase activity	J:522
Pnp^M1Btlr/Pnp^M1Btlr C57BL/6J-Pnp^M1Btlr	impaired humoral immune response	J:265147
Pnp^M1Btlr/Pnp^M1Btlr C57BL/6J-Pnp^M1Btlr	increased IgM level	J:265147
Pnp^m2Btlr/Pnp^m2Btlr C57BL/6J-Pnp^m2Btlr	decreased B-1a cell number	J:265150
	decreased B-2 B cell number	J:265150
	decreased CD4-positive, alpha-beta T cell number	J:265150
	decreased CD8-positive, naive alpha-beta T cell number	J:265150
	decreased T cell number	J:265150
	increased B-1b cell number	J:265150
	increased CD8-positive, alpha-beta memory T cell number	J:265150
	increased central memory CD4-positive, alpha-beta T cell number	J:265150
	increased central memory CD8 positive, alpha-beta T cell number	J:265150
	increased effector memory CD4-positive, alpha-beta T cell number	J:265150
	increased effector memory CD8-positive, alpha-beta T cell number	J:265150
Pnp^tm1Cmr/Pnp^tm1Cmr involves: 129	abnormal DNA repair	J:62870
	abnormal enzyme/coenzyme activity	J:62870
	abnormal mitochondrial physiology	J:62870
	abnormal myelopoiesis	J:62870
	abnormal urine nucleoside level	J:62870
	decreased CD4-positive, alpha-beta T cell number	J:62870
	decreased CD8-positive, alpha-beta T cell number	J:62870
	decreased cytotoxic T cell cytolysis	J:62870
	decreased double-positive T cell number	J:62870
	decreased purine-nucleoside phosphorylase activity	J:62870
	decreased single-positive T cell number	J:62870
	increased cellular sensitivity to gamma-irradiation	J:62870
	increased double-negative T cell number	J:62870
	increased pre-B cell number	J:62870
	increased thymocyte apoptosis	J:62870

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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