Npr1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Npr1
natriuretic peptide receptor 1
MGI:97371

40 phenotypes from 7 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Npr1^tm1(Npr1)Unc/Npr1⁺ involves: 129P2/OlaHsd * C57BL/6	decreased systemic arterial blood pressure	J:46175
Npr1^tm1(Npr1)Unc/Npr1^tm1(Npr1)Unc involves: 129P2/OlaHsd * C57BL/6	abnormal sex gland physiology	J:58344
	decreased systemic arterial blood pressure	J:46175
	increased circulating testosterone level	J:58344
Npr1^tm1.1Kkan/Npr1^tm1.1Kkan Tg(Tek-cre)1Ywa/0 involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * SJL	cardiac hypertrophy	J:220676
	increased metastatic potential	J:220676
	increased susceptibility to induced morbidity/mortality	J:220676
	increased systemic arterial blood pressure	J:220676
Npr1^tm1.1Rsha/Npr1⁺ involves: C57BL/6	cardiac hypertrophy	J:201932
	increased circulating aldosterone level	J:201932
	increased heart weight	J:201932
	increased mean systemic arterial blood pressure	J:201932
	increased systemic arterial systolic blood pressure	J:201932
Npr1^tm1.1Rsha/Npr1^tm1.1Rsha involves: C57BL/6	cardiac hypertrophy	J:201932
	increased circulating aldosterone level	J:201932
	increased heart weight	J:201932
	increased mean systemic arterial blood pressure	J:201932
	increased systemic arterial systolic blood pressure	J:201932
Npr1^tm1Gar/Npr1⁺ involves: 129S7/SvEvBrd * C57BL/6J	increased systemic arterial blood pressure	J:30007
	increased systemic arterial diastolic blood pressure	J:30007
	increased systemic arterial systolic blood pressure	J:30007
	salt-resistant hypertension	J:30007
Npr1^tm1Gar/Npr1^tm1Gar B6.129S7-Npr1^tm1Gar	decreased myocardial infarct size	J:70496
Npr1^tm1Gar/Npr1^tm1Gar B6.129S7-Npr1^tm1Gar	impaired neutrophil chemotaxis	J:70496
Npr1^tm1Gar/Npr1^tm1Gar involves: 129S7/SvEvBrd * C57BL/6J	abnormal systemic arterial blood pressure	J:42893
	abnormal vasodilation	J:42893
	hydrops fetalis	J:30007
	increased circulating atrial natriuretic factor	J:42893
	increased systemic arterial blood pressure	J:30007
	increased systemic arterial diastolic blood pressure	J:30007
	increased systemic arterial systolic blood pressure	J:30007
	normal mortality/aging	J:30007
	salt-resistant hypertension	J:30007
Npr1^tm1Kuhn/Npr1^tm1Kuhn Tg(Myh6-cre)2182Mds/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N	abnormal cardiac muscle relaxation	J:83298
	abnormal myocardial fiber morphology	J:83298
	cardiac hypertrophy	J:83298
	cardiac interstitial fibrosis	J:83298
	congestive heart failure	J:83298
	decreased systemic arterial systolic blood pressure	J:83298
	hypotension	J:83298
	increased circulating atrial natriuretic factor	J:83298
Npr1^tm1Kuhn/Npr1^tm1Kuhn Tg(Tagln-cre)1Her/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	abnormal systemic arterial blood pressure	J:76460
	abnormal vasodilation	J:76460
Npr1^tm1Mae/Npr1⁺ B6.129P2-Npr1^tm1Mae	congestive heart failure	J:101857
Npr1^tm1Mae/Npr1⁺ involves: 129P2/OlaHsd * C57BL/6	increased systemic arterial blood pressure	J:46175
Npr1^tm1Mae/Npr1^tm1Mae B6.129P2-Npr1^tm1Mae	cardiac hypertrophy	J:78579, J:101857
	congestive heart failure	J:101857
	enlarged heart	J:78579
	hypertension	J:78579
	increased circulating atrial natriuretic factor	J:78579
	normal mortality/aging	J:101857
Npr1^tm1Mae/Npr1^tm1Mae involves: 129P2/OlaHsd * C57BL/6	abnormal myocardium layer morphology	J:74420
	abnormal pulmonary circulation	J:74420
	abnormal sex gland physiology	J:58344
	aortic dissection	J:74420
	cardiac hypertrophy	J:74420
	cardiac interstitial fibrosis	J:74420
	congestive heart failure	J:74420
	decreased circulating renin level	J:74420
	decreased circulating testosterone level	J:58344
	dilated heart left ventricle	J:74420
	dilated heart right ventricle	J:74420
	myocardium necrosis	J:74420
	premature death	J:74420, J:101857
	pulmonary embolism	J:74420
	salt-resistant hypertension	J:74420
Tg(Tek-Npr1)#Kkan/0 involves: C57BL/6	decreased metastatic potential	J:220676
Tg(Tek-Npr1)#Kkan/0 involves: C57BL/6	decreased susceptibility to induced morbidity/mortality	J:220676

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24