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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Npr3
natriuretic peptide receptor 3
MGI:97373
78 phenotypes from 10 alleles in 11 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Npr3kylb/Npr3kylb
involves: BALB/c * C57BL/6J 		abnormal bone structure J:243806
abnormal vertebrae morphology J:243806
abnormal vertebral epiphyseal plate morphology J:243806
decreased total body fat amount J:243806
delayed endochondral bone ossification J:243806
elongated vertebral body J:243806
increased body length J:243806
increased bone mineral content J:243806
increased circulating alkaline phosphatase level J:243806
increased length of long bones J:243806
increased width of hypertrophic chondrocyte zone J:243806
kyphosis J:243806
Npr3lgj-2J/Npr3lgj-2J
DBA/2J 		abnormal abdominal fat pad morphology J:57460
abnormal adipose tissue distribution J:57460
abnormal adipose tissue morphology J:57460
abnormal axial skeleton morphology J:57460
abnormal caudal vertebrae morphology J:57460
abnormal sacral vertebrae morphology J:57460
abnormal skeleton development J:57460
abnormal thoracic cage morphology J:57460
abnormal vertebrae morphology J:57460
arachnodactyly J:57460
normal craniofacial phenotype J:57460
kinked tail J:57460
kyphosis J:57460
premature death J:57460
Npr3lgj-3J/Npr3lgj-3J
C57BL/6J-Npr3lgj-3J/GrsrJ 		abnormal axial skeleton morphology J:131428
abnormal digit morphology J:131428
abnormal skeleton development J:131428
abnormal vertebral column morphology J:131428
clinodactyly J:131428
increased or absent threshold for auditory brainstem response J:131428
kinked tail J:131428
kyphosis J:131428
Npr3lgj-4J/Npr3lgj-4J
NOD/ShiLtJ-Npr3lgj-4J/J 		abnormal caudal vertebrae morphology J:137503
arachnodactyly J:137503
increased body length J:137503
increased length of long bones J:137503
kinked tail J:137503
kyphosis J:137503
normal vision/eye phenotype J:137503
Npr3lgj/Npr3lgj
involves: BALB/cJ 		abnormal abdominal fat pad morphology J:57460
abnormal adipose tissue distribution J:57460
abnormal adipose tissue morphology J:57460
abnormal axial skeleton morphology J:57460
abnormal caudal vertebrae morphology J:57460
abnormal sacral vertebrae morphology J:57460
abnormal skeleton development J:57460
abnormal thoracic cage morphology J:57460
abnormal vertebrae morphology J:57460
arachnodactyly J:57460
normal craniofacial phenotype J:57460
kinked tail J:57460
Npr3m1Btlr/Npr3m1Btlr
C57BL/6J-Npr3m1Btlr 		elongated vertebral column J:132964
increased body length J:132964
kyphosis J:132964
long tail J:132964
Npr3skm1/Npr3skm1
involves: 129S1/SvImJ * 129X1/SvJ * DBA/2J 		abnormal skeleton development J:218364
arachnodactyly J:218364
caudal hemivertebra J:218364
caudal vertebral fusion J:218364
increased body length J:218364
kinked tail J:218364
kyphosis J:218364
thin body J:218364
Npr3stri/Npr3stri
involves: 129/Sv * FVB/N 		abnormal abdominal fat pad morphology J:57460
abnormal adipose tissue distribution J:57460
abnormal axial skeleton morphology J:57460
abnormal carpal bone morphology J:57460
abnormal caudal vertebrae morphology J:57460
abnormal intervertebral disk development J:57460
abnormal limb bone morphology J:57460
abnormal metacarpal bone morphology J:57460
abnormal nucleus pulposus morphology J:57460
abnormal phalanx morphology J:57460
abnormal sacral vertebrae morphology J:57460
abnormal skeleton development J:57460
abnormal vertebrae development J:57460
abnormal vertebrae morphology J:57460
abnormal vertebral epiphyseal plate morphology J:57460
absent nucleus pulposus J:57460
calcified intervertebral disk J:57460
delayed endochondral bone ossification J:57460
increased thoracic vertebrae number J:57460
kyphosis J:57460
Npr3tm1.1(KOMP)Vlcg/Npr3+
C57BL/6N-Npr3tm1.1(KOMP)Vlcg/Tcp 		increased circulating phosphate level J:211773
Npr3tm1.1(KOMP)Vlcg/Npr3tm1.1(KOMP)Vlcg
C57BL/6N-Npr3tm1.1(KOMP)Vlcg/Tcp 		abnormal testis morphology J:211773
small testis J:211773
Npr3tm1Unc/Npr3+
involves: 129 * C57BL/6 		abnormal urine nucleotide level J:56058
decreased urine osmolality J:56058
hypovolemia J:56058
increased erythrocyte cell number J:56058
increased hematocrit J:56058
increased hemoglobin content J:56058
polyuria J:56058
Npr3tm1Unc/Npr3tm1Unc
B6.129-Npr3tm1Unc 		abnormal interscapular fat pad morphology J:184488
decreased brown fat cell lipid droplet size J:184488
decreased epididymal fat pad weight J:184488
decreased inguinal fat pad weight J:184488
decreased interscapular fat pad weight J:184488
decreased retroperitoneal fat pad weight J:184488
decreased white fat cell size J:184488
Npr3tm1Unc/Npr3tm1Unc
involves: 129 * C57BL/6 		abnormal blood homeostasis J:56058
abnormal bone remodeling J:56058
abnormal bone trabecula morphology J:56058
abnormal long bone epiphyseal plate proliferative zone J:56058
abnormal osteoclast morphology J:56058
abnormal skeleton development J:56058
abnormal urine nucleotide level J:56058
decreased body weight J:56058
decreased urine osmolality J:56058
dehydration J:56058
delayed bone ossification J:56058
domed cranium J:56058
elongated metatarsal bones J:56058
elongated vertebral body J:56058
hunched posture J:56058
hypotension J:56058
hypovolemia J:56058
increased body length J:56058
increased circulating alkaline phosphatase level J:56058
increased erythrocyte cell number J:56058
increased hematocrit J:56058
increased hemoglobin content J:56058
increased length of long bones J:56058
increased osteoblast cell number J:56058
long tail J:56058
polydipsia J:56058
polyuria J:56058
postnatal lethality, incomplete penetrance J:56058
reduced fertility J:56058
small thoracic cage J:56058
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/10/2024
MGI 6.24 		The Jackson Laboratory