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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ntf3
neurotrophin 3
MGI:97380
121 phenotypes from 12 alleles in 18 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Egr3tm1(cre)Mod/Egr3tm1(cre)Mod
Ntf3tm2Jae/Ntf3tm2Jae
involves: 129S1/Sv * C57BL/6 		abnormal gait J:147957
abnormal nervous system electrophysiology J:147957
abnormal posture J:147957
ataxia J:147957
normal nervous system phenotype J:147957
Myf5tm3(cre)Sor/Myf5+
Ntf3tm2Jae/Ntf3tm2Jae
involves: 129S1/Sv * C57BL/6 		abnormal gait J:147957
abnormal nervous system electrophysiology J:147957
abnormal posture J:147957
ataxia J:147957
Ntf3tm1(Bdnf)Tes/Ntf3tm1(Bdnf)Tes
involves: 129S1/Sv 		abnormal dorsal root ganglion morphology J:72304
abnormal innervation J:72304
abnormal motor coordination/balance J:72304
abnormal posture J:72304
abnormal sensory neuron innervation pattern J:72304
abnormal sensory neuron morphology J:72304
abnormal vestibulocochlear ganglion morphology J:72304
absent muscle spindles J:72304
absent proprioceptive neurons J:72304
decreased neuron number J:72304
normal nervous system phenotype J:72304
Ntf3tm1.1Eafx/Ntf3tm1.1Eafx
B6.129S2-Ntf3tm1.1Eafx 		abnormal motor coordination/balance J:201812
hunched posture J:201812
limb grasping J:201812
postnatal growth retardation J:201812
Ntf3tm1Esm/Ntf3tm1Esm
involves: 129S1/Sv 		no abnormal phenotype detected J:82354
Ntf3tm1Esm/Ntf3tm1Esm
Foxg1tm1(cre)Skm/Foxg1+
involves: 129P2/OlaHsd * 129S1/Sv 		abnormal nervous system tract morphology J:81563
abnormal vision J:81563
decreased CNS synapse formation J:81563
Ntf3tm1Esm/Ntf3tm1Esm
Tg(GFAP-cre)25Mes/0
involves: 129S1/Sv * FVB/N 		abnormal nervous system tract morphology J:81563
abnormal vision J:81563
Ntf3tm1Esm/Ntf3tm1Esm
Tg(Syn1-cre)671Jxm/0
involves: 129S1/Sv * C57BL/6 * CBA 		normal nervous system phenotype J:82354
Ntf3tm1Jae/Ntf3+
involves: 129S4/SvJae * BALB/c 		abnormal cardiovascular system physiology J:62748
abnormal dorsal root ganglion morphology J:53825
abnormal muscle morphology J:23882, J:53825
abnormal noradrenaline level J:62748
abnormal stellate ganglion morphology J:62748
decreased heart rate J:62748
decreased sensory neuron number J:53825
Ntf3tm1Jae/Ntf3tm1Jae
involves: 129S4/SvJae 		abnormal dorsal root ganglion morphology J:43444
absent muscle spindles J:43444
absent proprioceptive neurons J:43444
postnatal lethality, complete penetrance J:43444
Ntf3tm1Jae/Ntf3tm1Jae
involves: 129S4/SvJae * BALB/c 		abnormal dorsal root ganglion morphology J:23882
abnormal innervation pattern to muscle J:23882
abnormal muscle morphology J:23882
abnormal proprioceptive neuron morphology J:23882
abnormal sensory capabilities/reflexes/nociception J:23882
abnormal stellate ganglion morphology J:62748
absent golgi tendon organ J:23882
absent muscle spindles J:23882
ataxia J:23882
decreased body size J:23882
decreased body weight J:62748
impaired limb coordination J:23882
postnatal lethality, complete penetrance J:23882
small dorsal root ganglion J:23882
small mesencephalic trigeminal nucleus J:23882
small nodose ganglion J:23882
small superior cervical ganglion J:23882
small trigeminal ganglion J:23882
Ntf3tm1Jae/Ntf3tm1Jae
involves: 129S4/SvJae * C57BL/6 		abnormal dorsal root ganglion morphology J:83461
absent muscle spindles J:83461
absent proprioceptive neurons J:83461
Ntf3tm1Jae/Ntf3tm1Jae
involves: 129S4/SvJae * C57BL/6J 		abnormal innervation pattern to muscle J:90280
abnormal sensory neuron innervation pattern J:90280
Ntf3tm1Jae/Ntf3tm1Jae
Tg(Myog-Ntf3)5160Wds/0
involves: C57BL/6 * CBA * CF-1 		abnormal dorsal root ganglion morphology J:43444
abnormal muscle spindle morphology J:43444
abnormal proprioceptive neuron morphology J:43444
postnatal lethality, complete penetrance J:43444
Ntf3tm1Lfr/Ntf3tm1Lfr
involves: 129S2/SvPas 		abnormal cranial ganglia morphology J:18984
abnormal food intake J:18984
abnormal limb posture J:18984
abnormal muscle spindle morphology J:132854
abnormal sensory neuron innervation pattern J:18984
absent muscle spindles J:18984
athetotic walking movements J:18984
cochlear ganglion hypoplasia J:18984
decreased locomotor activity J:18984
decreased motor neuron number J:132854
neonatal lethality, incomplete penetrance J:18984
small dorsal root ganglion J:18984
small geniculate ganglion J:18984
small L5 dorsal root ganglion J:18984
small mesencephalic trigeminal nucleus J:18984
small superior cervical ganglion J:18984
small trigeminal ganglion J:18984
Ntf3tm1Lfr/Ntf3tm1Lfr
involves: 129S2/SvPas * C57BL/6J 		abnormal sensory neuron innervation pattern J:90280
Ntf3tm1Mpin/Ntf3+
involves: 129S1/Sv 		abnormal cutaneous/subcutaneous mechanoreceptor morphology J:79302
abnormal Merkel's receptor morphology J:79302
abnormal sensory neuron innervation pattern J:79302
normal nervous system phenotype J:79302
Ntf3tm1Mpin/Ntf3tm1Mpin
involves: 129S1/Sv 		abnormal Merkel's receptor morphology J:79302
abnormal sensory neuron innervation pattern J:79302
ataxia J:79302
neonatal lethality, incomplete penetrance J:79302
postnatal lethality, complete penetrance J:79302
Ntf3tm1Par/Ntf3+
involves: 129S1/Sv 		abnormal heart morphology J:35639
anomalous pulmonary venous connection J:35639
heart right ventricle outflow tract stenosis J:35639
increased heart right ventricle size J:35639
ostium secundum atrial septal defect J:35639
pulmonary valve stenosis J:35639
thick pulmonary valve cusps J:35639
Ntf3tm1Par/Ntf3tm1Par
involves: 129S1/Sv 		abnormal atrioventricular valve morphology J:35639
abnormal atrium myocardial trabeculae morphology J:35639
abnormal blood vessel morphology J:67562
abnormal cardiovascular system morphology J:35639
abnormal dorsal root ganglion morphology J:154926
abnormal heart development J:35639
abnormal heart left ventricle size J:35639
abnormal heart morphology J:67562
abnormal heart valve morphology J:35639
abnormal heart ventricle morphology J:35639
abnormal heart ventricle outflow tract morphology J:35639
abnormal motor capabilities/coordination/movement J:67562
abnormal posture J:67562
abnormal proprioceptive neuron morphology J:67562
abnormal pulmonary vein morphology J:35639
abnormal semilunar valve morphology J:35639
abnormal sinus venosus morphology J:35639
abnormal somatic nervous system morphology J:44286
aneurysm J:35639
atrium myocardium hypoplasia J:35639
cardiac hypertrophy J:35639
decreased body weight J:67562
decreased heart rate J:35639
decreased sensory neuron number J:44286, J:60927
decreased spinal cord size J:67562
dilated heart atrium J:35639
dilated heart right ventricle J:35639
dilated pulmonary artery J:35639
enlarged heart J:35639
heart right ventricle outflow tract stenosis J:35639
ostium secundum atrial septal defect J:35639
overriding aortic valve J:35639
perimembraneous ventricular septal defect J:35639
perinatal lethality, incomplete penetrance J:44286, J:67562
persistent truncus arteriosus J:35639
postnatal lethality, complete penetrance J:67562
premature closure of the ductus arteriosus J:35639
pulmonary alveolar hemorrhage J:35639
pulmonary edema J:35639
pulmonary valve stenosis J:35639
sinus venosus hypoplasia J:35639
small dorsal root ganglion J:60927
small geniculate ganglion J:44286
small L4 dorsal root ganglion J:44286
small nodose ganglion J:44286
small petrosal ganglion J:44286
small trigeminal ganglion J:44286, J:60927
thick aortic valve cusps J:35639
thick mitral valve cusps J:35639
vascular smooth muscle hypotrophy J:35639
Ntf3tm1Par/Ntf3tm1Par
involves: 129S1/Sv * C57BL/6 		perinatal lethality, incomplete penetrance J:45083
small cochlear ganglion J:45083
small geniculate ganglion J:45083
small L5 dorsal root ganglion J:45083
small nodose ganglion J:45083
small petrosal ganglion J:45083
small superior cervical ganglion J:45083
small trigeminal ganglion J:45083
Ntf3tm1Par/Ntf3tm2Jae
Tg(Tagln-cre)1Her/0
involves: 129S1/Sv * C57BL/6 * SJL 		abnormal eating behavior J:201812
abnormal nervous system physiology J:201812
normal growth/size/body region phenotype J:201812
Ntf3tm1Tojo/Ntf3tm1Tojo
involves: C57BL/6 * DBA/2 * ICR 		abnormal estrous cycle J:22369
abnormal sensory ganglion morphology J:22369
abnormal suckling behavior J:22369
abnormal suckling reflex J:22369
ataxia J:22369
decreased body size J:22369
decreased survivor rate J:22369
female infertility J:22369
muscular atrophy J:22369
normal nervous system phenotype J:22369
postnatal lethality, incomplete penetrance J:22369
small dorsal root ganglion J:22369
small trigeminal ganglion J:22369
Ntf3tm2.1Jae/Ntf3tm2Jae
Olig2tm2(cre)Htak/Olig2+
Not Specified 		abnormal dorsal root ganglion morphology J:182750
abnormal proprioceptive neuron morphology J:182750
abnormal sensory neuron innervation pattern J:182750
Ntf3tm2Jae/Ntf3+
Tg(Tagln-cre)1Her/0
involves: 129S1/Sv * C57BL/6 * SJL 		abnormal eating behavior J:201812
Ntf3tm2Jae/Ntf3tm2Jae
Not Specified 		no abnormal phenotype detected J:52951
Ntf3tm2Jae/Ntf3tm2Jae
Tg(Nes-cre)1Atp/?
involves: FVB/N 		abnormal cerebellar foliation J:52951
abnormal cerebellar granule layer morphology J:52951
Ntf3tm2Jae/Ntf3tm2Jae
Tg(PLAT-cre)116Sdu/0
Not Specified 		normal nervous system phenotype J:197913
Tg(Myog-Ntf3)5160Wds/0
involves: C57BL/6 * CBA * CF-1 		abnormal dorsal root ganglion morphology J:43444
abnormal muscle spindle morphology J:43444
abnormal proprioceptive neuron morphology J:43444
Tg(Ntf3)1Kma/0
involves: C3H * C57BL/6 		abnormal cranial ganglia morphology J:34172
abnormal keratinocyte morphology J:54992
abnormal mechanoreceptor morphology J:34172
abnormal sympathetic ganglion morphology J:34172
hyperinnervation of hair guard cells J:34172
hyperinnervation of hair-tylotrich cells J:34172
hyperinnervation of Merkel's receptor J:34172
increased Merkel's receptor number J:34172
L4 dorsal root ganglion hypertrophy J:34172
L5 dorsal root ganglion hypertrophy J:34172
superior cervical ganglion hypertrophy J:34172
thick epidermis J:54992
trigeminal ganglion hypertrophy J:34172
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory