Oprk1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Oprk1
opioid receptor, kappa 1
MGI:97439

15 phenotypes from 5 alleles in 9 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Oprk1^tm1.1Waca/Oprk1^tm1.1Waca Tg(Slc6a3-icre)9075Gsc/0 B6J.Cg-Oprk1^tm1.1Waca Tg(Slc6a3-icre)9075Gsc	normal behavior/neurological phenotype	J:211750
	decreased anxiety-related response	J:211750
	enhanced behavioral response to cocaine	J:211750
Oprk1^tm1.2Waca/Oprk1^tm1.2Waca B6J.B6NTac(Cg)-Oprk1^tm1.2Waca	normal behavior/neurological phenotype	J:211750
	decreased chemically-elicited antinociception	J:211750
Oprk1^tm1Jep/Oprk1^tm1Jep involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6	decreased chemically-elicited antinociception	J:157606
Oprk1^tm1Jep/Oprk1^tm1Jep involves: 129S/SvEv * C57BL/6	abnormal chemically-elicited antinociception	J:226396
	abnormal locomotor activation	J:226396
	abnormal synaptic dopamine release	J:226396
Oprk1^tm1Jep/Oprk1^tm1Jep involves: C57BL/6	abnormal avoidance learning behavior	J:154773
Oprk1^tm1Jep/Oprk1^tm1Jep Not Specified	impaired behavioral response to anesthetic	J:65217
Oprk1^tm1Kff/Oprk1⁺ involves: 129S2/SvPas * C57BL/6	increased litter size	J:46089
Oprk1^tm1Kff/Oprk1^tm1Kff involves: 129S2/SvPas * C57BL/6	abnormal locomotor behavior	J:46089
	abnormal pain threshold	J:46089
	decreased salivation	J:46089
	impaired behavioral response to morphine	J:46089
	increased litter size	J:46089
Oprk1^tm2.1Kff/Oprk1^tm2.1Kff Slc6a3^tm1(cre)Xz/0 involves: 129 * 129S1/Sv * C57BL/6	abnormal associative learning	J:226396
	abnormal synaptic dopamine release	J:226396
Oprk1^tm2.1Kff/Oprk1^tm2.1Kff Tg(Fev-cre)1Esd/0 involves: 129 * C57BL/6 * SJL	abnormal associative learning	J:226396

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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