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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Oprm1
opioid receptor, mu 1
MGI:97441
57 phenotypes from 16 alleles in 21 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Oprm1IAP/Oprm1IAP
CXB7/ByJ 		decreased thermal nociceptive threshold J:283389
impaired behavioral response to morphine J:283389
Oprm1tm1.1Cgrf/Oprm1tm1.1Cgrf
Scn10atm2(cre)Jwo/Scn10a+
involves: 129 * C57BL/6J 		abnormal behavioral response to addictive substance J:207536
normal behavior/neurological phenotype J:207536
normal homeostasis/metabolism phenotype J:207536
normal integument phenotype J:207536
Oprm1tm1.1Jbwa/Oprm1tm1.1Jbwa
involves: 129S6/SvEvTac * C57BL/6 		enhanced behavioral response to addictive substance J:101977
Oprm1tm1.2Cgrf/Oprm1tm1.2Cgrf
involves: 129 * C57BL/6 * C57BL/6J * SJL 		decreased physiological sensitivity to xenobiotic J:207536
Oprm1tm1Jep/Oprm1+
B6.129S-Oprm1tm1Jep 		abnormal operant conditioning behavior J:101294
enhanced behavioral response to addictive substance J:101294
induced hyperactivity J:101294
Oprm1tm1Jep/Oprm1+
involves: 129S/SvEv 		enhanced behavioral response to anesthetic J:65217
impaired behavioral response to anesthetic J:52952, J:65217
impaired behavioral response to morphine J:52952, J:65217
Oprm1tm1Jep/Oprm1tm1Jep
B6.129S-Oprm1tm1Jep 		abnormal lean body mass J:147786
abnormal operant conditioning behavior J:101294
enhanced behavioral response to addictive substance J:101294
enlarged pancreatic islets J:147786
impaired ability to fire action potentials J:101066
improved glucose tolerance J:147786
increased body weight J:147786
increased circulating insulin level J:147786
increased insulin secretion J:147786
increased pancreas weight J:147786
increased percent body fat/body weight J:147786
increased total body fat amount J:147786
induced hyperactivity J:101294
Oprm1tm1Jep/Oprm1tm1Jep
involves: 129S/SvEv 		enhanced behavioral response to anesthetic J:65217
impaired behavioral response to anesthetic J:52952, J:65217
impaired behavioral response to morphine J:52952, J:65217
Oprm1tm1Jep/Oprm1tm1Jep
Tg(Th-Oprm1)4Jtw/0
involves: 129S/SvEv * C57BL/6 * DBA/2 		normal nervous system phenotype J:151536
Oprm1tm1Jlw/Oprm1tm1Jlw
involves: 129P2/OlaHsd 		abnormal behavioral response to addictive substance J:131412
increased chemically-elicited antinociception J:131412
Oprm1tm1Kff/Oprm1tm1Kff
involves: 129S2/SvPas 		abnormal pain threshold J:36241, J:62551
decreased behavioral withdrawal response J:62551
decreased locomotor activity J:36241
impaired behavioral response to anesthetic J:52952
impaired behavioral response to morphine J:36241, J:52952, J:207536
increased coping response J:62551
Oprm1tm1Kff/Oprm1tm1Kff
involves: 129S2/SvPas * C57BL/6J 		abnormal social investigation J:204731
Oprm1tm1Lex/Oprm1tm1Lex
involves: 129S5/SvEvBrd * C57BL/6NTac 		decreased chemically-elicited antinociception J:170718
decreased physiological sensitivity to xenobiotic J:170718
impaired behavioral response to morphine J:170718
increased thermal nociceptive threshold J:170718
Oprm1tm1Loh/Oprm1+
involves: 129P2/OlaHsd 		decreased chemically-elicited antinociception J:47187
decreased susceptibility to xenobiotic induced morbidity/mortality J:47187
Oprm1tm1Loh/Oprm1tm1Loh
involves: 129P2/OlaHsd 		abnormal spatial learning J:85653
decreased chemically-elicited antinociception J:47187
decreased susceptibility to xenobiotic induced morbidity/mortality J:47187
enhanced behavioral response to cocaine J:107973
impaired behavioral response to morphine J:47187, J:107973
Oprm1tm1Loh/Oprm1tm1Loh
involves: 129P2/OlaHsd * BALB/c * C57BL/6 		abnormal excitatory postsynaptic potential J:61244
reduced long-term potentiation J:61244
Oprm1tm1Loh/Oprm1tm1Loh
involves: 129P2/OlaHsd * BALB/cJ * C57BL/6J 		abnormal nervous system physiology J:106367
Oprm1tm1Loh/Oprm1tm1Loh
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		abnormal circulating glucose level J:106857
Oprm1tm1Lyu/Oprm1+
involves: Black Swiss 		abnormal bone marrow cell physiology J:39864
abnormal copulatory plug deposition J:39864
decreased locomotor activity J:39864
impaired behavioral response to morphine J:39864
increased splenocyte proliferation J:39864
increased vertical activity J:39864
Oprm1tm1Lyu/Oprm1tm1Lyu
involves: Black Swiss 		abnormal bone marrow cell physiology J:39864
abnormal common myeloid progenitor cell morphology J:39864
abnormal copulatory plug deposition J:39864
abnormal intromission J:39864
asthenozoospermia J:39864
decreased chemically-elicited antinociception J:39864
decreased copulatory plug deposition J:39864
decreased litter size J:39864
decreased locomotor activity J:39864
decreased mounting behavior J:39864
impaired behavioral response to morphine J:39864
increased erythroid progenitor cell number J:39864
increased splenocyte proliferation J:39864
increased vertical activity J:39864
oligozoospermia J:39864
reduced male fertility J:39864
Oprm1tm1Shlz/Oprm1tm1Shlz
involves: C57BL/6 		abnormal chemically-elicited antinociception J:176122
enhanced behavioral response to morphine J:176122
increased chemically-elicited antinociception J:176122
Oprm1tm1Uhl/Oprm1+
either: B6.129S7-Oprm1tm1Uhl or (involves: 129S7/SvEvBrd) 		decreased physiological sensitivity to xenobiotic J:106256
decreased susceptibility to xenobiotic induced morbidity/mortality J:106256
enhanced conditioned place preference behavior J:106256
Oprm1tm1Uhl/Oprm1tm1Uhl
involves: 129S7/SvEvBrd * C57BL/6J 		abnormal pain threshold J:38597
decreased susceptibility to xenobiotic induced morbidity/mortality J:106256
decreased thermal nociceptive threshold J:38597
impaired behavioral response to morphine J:106256
Oprm1tm1Yxp/Oprm1tm1Yxp
involves: 129/Sv * C57BL/6 		abnormal intestinal transit time J:147079
decreased chemically-elicited antinociception J:147079
Oprm1tm2.1Loh/Oprm1tm2.1Loh
Not Specified 		abnormal touch/ nociception J:81978
Oprm1tm2Loh/Oprm1tm2Loh
Not Specified 		no abnormal phenotype detected J:81978
Tg(Th-Oprm1)4Jtw/0
involves: C57BL/6 * DBA/2 		normal nervous system phenotype J:151536
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory