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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Otx1
orthodenticle homeobox 1
MGI:97450
47 phenotypes from 3 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Otx1jv/Otx1jv
C57BL/6J-Otx1jv/GrsrJ 		abnormal utricle morphology J:13457
abnormal vestibular saccule morphology J:13457
absent lateral semicircular canal J:13457, J:86284
circling J:13457, J:86284
head shaking J:13457, J:86284
normal hearing/vestibular/ear phenotype J:86284
Otx1tm1Asim/Otx1tm1Asim
involves: 129P2/OlaHsd 		abnormal cerebral cortex morphology J:52989
abnormal inner ear morphology J:52989
abnormal telencephalon development J:52989
absent ciliary process J:52989
absent Harderian gland J:52989
absent lacrimal glands J:52989
absent lateral semicircular canal J:52989
decreased brain size J:52989
decreased brain weight J:52989
premature death J:47322
seizures J:52989
Otx1tm1Asim/Otx1tm1Asim
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		abnormal cerebral cortex morphology J:35640
abnormal iris morphology J:35640
abnormal midbrain morphology J:35640
abnormal ovarian folliculogenesis J:47322
abnormal pituitary secretion J:47322
abnormal seminiferous tubule morphology J:47322
absent Harderian gland J:35640
absent lacrimal glands J:35640
absent semicircular canals J:35640
arrest of spermatogenesis J:47322
convulsive seizures J:35640
decreased body weight J:47322
decreased brain weight J:47322
decreased circulating testosterone level J:47322
delayed fertility J:47322
increased cerebellar foliation J:35640
increased inferior colliculus size J:35640
increased superior colliculus size J:35640
nonconvulsive seizures J:35640
postnatal growth retardation J:47322
premature death J:47322
small ovary J:47322
small testis J:47322
Otx1tm1Sia/Otx1tm1Sia
involves: C57BL/6 * CBA 		abnormal cartilage morphology J:73592
abnormal cerebral cortex morphology J:73592
abnormal cranium morphology J:73592
abnormal eye anterior chamber morphology J:73592
abnormal lens morphology J:73592
abnormal nervous system morphology J:73592
abnormal orbitosphenoid bone morphology J:73592
abnormal third ventricle morphology J:73592
abnormal trigeminal V mesencephalic nucleus morphology J:73592
absent lacrimal glands J:73592
increased cornea thickness J:73592
meteorism J:73592
neonatal lethality, complete penetrance J:73592
retina hyperplasia J:73592
small hippocampus J:73592
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory