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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Otx1
orthodenticle homeobox 1
MGI:97450
74 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Emx1tm1Sia/Emx1tm1Sia
Otx1tm1Sia/Otx1tm1Sia
Not Specified 		normal nervous system phenotype J:98539
Emx2tm1Sia/Emx2tm1Sia
Otx1tm1Sia/Otx1tm1Sia
involves: C57BL/6 * CBA 		abnormal Ammon gyrus morphology J:98539
abnormal cerebral cortex morphology J:98539
abnormal forebrain morphology J:98539
abnormal hippocampus morphology J:98539
abnormal pretectal region morphology J:98539
abnormal telencephalon morphology J:98539
small thalamus J:98539
Otx1tm1Asim/Otx1tm1Asim
Otx2tm1Pas/Otx2+
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		abnormal dopaminergic neuron morphology J:88192
abnormal neuron morphology J:88192
abnormal serotonergic neuron morphology J:88192
Otx1tm1Asim/Otx1tm2(otd)Asim
Otx2tm1Pas/Otx2+
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		abnormal brain morphology J:47899
abnormal cerebellum morphology J:47899
abnormal midbrain morphology J:47899
perinatal lethality, complete penetrance J:47899
Otx1tm1Sia/Otx1+
Otx2tm1Sia/Otx2+
involves: C57BL/6 * CBA 		abnormal brain development J:51989
abnormal cartilage morphology J:73592
abnormal cerebral cortex morphology J:73592
abnormal cerebral hemisphere morphology J:51989
abnormal cranium morphology J:73592
abnormal diencephalon morphology J:73592
abnormal forebrain morphology J:51989
abnormal hypothalamus morphology J:73592
abnormal inferior colliculus morphology J:73592
abnormal mammillary body morphology J:73592
abnormal metencephalon morphology J:51989
abnormal midbrain morphology J:51989, J:73592
abnormal midbrain-hindbrain boundary morphology J:51989
abnormal nervous system morphology J:73592
abnormal oculomotor nerve morphology J:73592
abnormal oculomotor nucleus morphology J:73592
abnormal optic nerve morphology J:73592
abnormal orbitosphenoid bone morphology J:73592
abnormal posterior commissure morphology J:73592
abnormal pretectal region morphology J:51989
abnormal red nucleus morphology J:73592
abnormal rhombic lip morphology J:73592
abnormal sphenoid bone morphology J:73592
abnormal superior colliculus morphology J:73592
abnormal tegmentum morphology J:73592
abnormal telencephalon morphology J:51989, J:73592
abnormal trigeminal V mesencephalic nucleus morphology J:73592
abnormal trochlear nerve morphology J:73592
basisphenoid bone foramen J:73592
decreased midbrain size J:73592
decreased substantia nigra size J:73592
enlarged cerebellum J:51989, J:73592
enlarged cerebral aqueduct J:73592
increased pons size J:51989
prenatal lethality, complete penetrance J:73592
presphenoid bone hypoplasia J:73592
small hippocampus J:51989, J:73592
small olfactory bulb J:73592
small thalamus J:51989, J:73592
Otx1tm1Sia/Otx1+
Otx2tm2(Otx1)Sia/Otx2+
involves: C57BL/6 * CBA 		abnormal midbrain-hindbrain boundary morphology J:51989
decreased midbrain size J:51989
increased rhombomere 1 size J:51989
Otx1tm1Sia/Otx1tm1Sia
Otx2tm5Sia/Otx2tm5Sia
involves: C57BL/6NCrlj * CBA/JNCrlj 		abnormal brain development J:91011
absent diencephalon J:91011
absent midbrain J:91011
Otx1tm1Sia/Otx1tm1Sia
Otx2tm8.2Sia/Otx2tm8.2Sia
involves: C57BL/6 * CBA 		abnormal cerebral cortex morphology J:166617
abnormal embryonic/fetal subventricular zone morphology J:166617
abnormal midbrain-hindbrain boundary morphology J:166617
absent diencephalon J:166617
absent midbrain J:166617
absent tectum J:166617
absent tegmentum J:166617
increased pons size J:166617
Otx1tm1Sia/Otx1tm1Sia
Otx2tm10Sia/Otx2tm10Sia
involves: C57BL/6NCrlj * CBA/JNCrlj 		abnormal embryonic neuroepithelium morphology J:207608
Otx1tm2(otd)Asim/Otx1tm2(otd)Asim
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		abnormal cerebellar foliation J:47899
abnormal eye morphology J:47899
abnormal iris morphology J:47899
abnormal midbrain morphology J:47899
abnormal telencephalon development J:47899
absent Harderian gland J:47899
absent lacrimal glands J:47899
absent lateral semicircular canal J:47899
normal behavior/neurological phenotype J:47899
decreased brain size J:47899
decreased brain weight J:47899
decreased inferior colliculus size J:47899
decreased superior colliculus size J:47899
normal nervous system phenotype J:47899
postnatal lethality, incomplete penetrance J:47899
Otx1tm2(otd)Asim/Otx1tm2(otd)Asim
Otx2tm1Pas/Otx2+
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		abnormal midbrain morphology J:47899
Otx1tm3(OTX2)Asim/Otx1tm3(OTX2)Asim
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		abnormal cerebellar foliation J:52989
abnormal inner ear morphology J:52989
abnormal telencephalon development J:52989
absent ciliary process J:52989
absent Harderian gland J:52989
absent lacrimal glands J:52989
absent lateral semicircular canal J:52989
normal behavior/neurological phenotype J:52989
decreased brain size J:52989
decreased brain weight J:52989
decreased midbrain size J:52989
normal mortality/aging J:52989
normal nervous system phenotype J:52989
Otx1tm4(cre)Asim/Otx1+
Otx2tm6Asim/Otx2tm6.1Asim
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 		abnormal midbrain-hindbrain boundary morphology J:83110
abnormal neuronal precursor proliferation J:83110
abnormal tegmentum morphology J:83110
neonatal lethality, complete penetrance J:83110
small tectum J:83110
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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07/02/2024
MGI 6.13 		The Jackson Laboratory