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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Otx2
orthodenticle homeobox 2
MGI:97451
175 phenotypes from 28 alleles in 14 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Gt(ROSA)26Sortm1.1(Otx2)Daac/Gt(ROSA)26Sor+
Slc6a3tm1.1(cre)Bkmn/Slc6a3+
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		decreased susceptibility to dopaminergic neuron neurotoxicity J:166896
Gt(ROSA)26Sortm1.1(Otx2)Daac/Gt(ROSA)26Sortm1.1(Otx2)Daac
Slc6a3tm1.1(cre)Bkmn/Slc6a3+
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		decreased dopaminergic neuron number J:166896
decreased susceptibility to dopaminergic neuron neurotoxicity J:166896
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Tg(CAG-Otx2,-EGFP)1Eno/?
involves: C3H * C57BL/6 		failure of intramembranous bone ossification J:150709
frontal bone foramen J:150709
intracranial hemorrhage J:150709
neonatal lethality, complete penetrance J:150709
Otx1tm4(cre)Asim/Otx1+
Otx2tm6Asim/Otx2tm6.1Asim
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 		abnormal midbrain-hindbrain boundary morphology J:83110
abnormal neuronal precursor proliferation J:83110
abnormal tegmentum morphology J:83110
neonatal lethality, complete penetrance J:83110
small tectum J:83110
Otx2tm1.1Tlam/Otx2tm2(cre/ERT2)Tlam
129/Sv 		abnormal eye development J:116888
abnormal forebrain development J:116888
abnormal inferior colliculus morphology J:116888
abnormal mandible morphology J:116888
abnormal midbrain morphology J:116888
decreased body size J:116888
decreased inferior colliculus size J:116888
loss of dopaminergic neurons J:116888
postnatal growth retardation J:116888
postnatal lethality J:116888
Otx2tm1.2Tlam/Otx2tm1.2Tlam
involves: C57BL/6 * DBA/2 		embryonic-extraembryonic boundary constriction J:116888
Otx2tm1Pas/Otx2+
involves: C57BL/6 * FVB/N 		abnormal gonadotroph morphology J:210118
decreased circulating luteinizing hormone level J:210118
decreased gonadotroph cell number J:210118
decreased litter size J:210118
decreased testis weight J:210118
preweaning lethality, incomplete penetrance J:210118
reduced male fertility J:210118
Otx2tm1Pas/Otx2tm1Pas
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		abnormal amnion morphology J:29276
abnormal developmental patterning J:29276
abnormal embryonic tissue morphology J:29276
abnormal hindbrain development J:29276
abnormal mesoderm development J:29276
abnormal neural tube morphology J:29276
abnormal primitive node morphology J:29276
abnormal somite development J:29276
abnormal somite shape J:29276
absent forebrain J:29276
absent midbrain J:29276
absent nasal placodes J:29276
absent optic vesicle J:29276
absent pharyngeal arches J:29276
decreased embryo size J:29276
embryonic growth retardation J:29276
prenatal lethality, complete penetrance J:29276
rostral body truncation J:29276
small heart J:29276
Otx2tm1Pas/Otx2tm2Asim
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		abnormal brain development J:71034, J:72725
abnormal first pharyngeal arch morphology J:71034
abnormal forebrain development J:71034
abnormal maxillary prominence morphology J:71034
abnormal midbrain development J:71034
acephaly J:71034, J:72725
Otx2tm1Sia/Otx2+
involves: C57BL/6 * CBA 		abnormal adenohypophysis morphology J:29682
abnormal alisphenoid bone morphology J:29682
abnormal anterior eye segment morphology J:29682
abnormal basisphenoid bone morphology J:29682
abnormal ciliary ganglion morphology J:29682
abnormal craniofacial morphology J:70745
abnormal cranium morphology J:29682
abnormal embryonic neuroepithelium morphology J:29682
abnormal extraocular muscle morphology J:29682
abnormal eye distance/ position J:29682
abnormal eye morphology J:51989
abnormal eyelid morphology J:29682
abnormal hindbrain morphology J:29682
abnormal incus morphology J:29682
abnormal inferior colliculus morphology J:29682
abnormal malleus morphology J:29682
abnormal mandible morphology J:29682, J:51989
abnormal Meckel's cartilage morphology J:29682
abnormal midbrain-hindbrain boundary morphology J:29682
abnormal nasal capsule morphology J:29682
abnormal nasal cavity morphology J:29682
abnormal nasal septum morphology J:29682
abnormal oculomotor nerve morphology J:29682
abnormal olfactory epithelium morphology J:29682
abnormal palate morphology J:29682
abnormal presphenoid bone morphology J:29682
abnormal pterygoid bone morphology J:29682
abnormal retina layer morphology J:29682
abnormal sclera morphology J:29682
abnormal snout morphology J:29682
abnormal temporal bone tympanic part morphology J:29682
abnormal third ventricle morphology J:29682
abnormal trigeminal nerve morphology J:29682
abnormal trigeminal V mesencephalic nucleus morphology J:29682
abnormal trochlear nerve morphology J:29682
abnormal vomeronasal organ morphology J:29682
absent choroid plexus J:29682
absent cornea J:29682
absent forebrain J:29682
absent mandible J:29682
absent mandibular coronoid process J:29682
absent metencephalon J:29682
absent midbrain J:29682
absent nasal capsule J:29682
absent nasal septum J:29682
absent nasopharynx J:29682
absent olfactory bulb J:29682
absent orbitosphenoid bone J:29682
absent tongue J:29682
absent vomeronasal organ J:29682
acephaly J:29682, J:51989
aniridia J:29682
anophthalmia J:29682
aphakia J:29682
basisphenoid bone foramen J:29682
decreased embryonic neuroepithelium thickness J:29682
ethmocephaly J:29682
micrognathia J:29682
microphthalmia J:29682
neonatal lethality, incomplete penetrance J:29682
premature death J:29682
retina pigment epithelium hyperplasia J:29682
short snout J:29682
small cranium J:29682
Otx2tm1Sia/Otx2tm1Sia
involves: C57BL/6 * CBA 		abnormal anterior head development J:29682
abnormal brain development J:51989
abnormal gastrulation J:51989
abnormal mesendoderm development J:51989
absent forebrain J:29682
absent foregut J:29682
absent heart J:29682
absent midbrain J:29682
embryonic growth arrest J:29682
embryonic lethality during organogenesis, complete penetrance J:29682
rostral body truncation J:29682
Otx2tm1Sia/Otx2tm4.1Sia
involves: C57BL/6 * CBA * FVB/N 		no abnormal phenotype detected J:74631
Otx2tm1Sia/Otx2tm4Sia
involves: C57BL/6 * CBA 		abnormal brain development J:74631
abnormal cranium morphology J:74631
abnormal metencephalon morphology J:74631
abnormal midbrain morphology J:74631
abnormal midbrain-hindbrain boundary morphology J:74631
abnormal nervous system development J:74631
absent diencephalon J:74631
absent embryonic telencephalon J:74631
anencephaly J:74631
normal embryo phenotype J:74631
exencephaly J:74631
open neural tube J:74631
Otx2tm1Sia/Otx2tm5Sia
involves: C57BL/6NCrlj * CBA/JNCrlj 		abnormal brain development J:91011
absent diencephalon J:91011
absent midbrain J:91011
Otx2tm1Sia/Otx2tm6Sia
involves: C57BL/6NCrlj * CBA/JNCrlj 		abnormal brain development J:91011
Otx2tm1Sia/Otx2tm9Sia
involves: C57BL/6NCrlj * CBA/JNCrlj 		abnormal embryonic neuroepithelium morphology J:207608
abnormal forebrain morphology J:207608
Otx2tm1Sia/Otx2tm10Sia
involves: C57BL/6NCrlj * CBA/JNCrlj 		abnormal embryonic neuroepithelium morphology J:207608
abnormal forebrain morphology J:207608
Otx2tm1Sla/Otx2+
involves: 129S1/Sv * 129X1/SvJ * CD-1 		open neural tube J:30828
preweaning lethality, incomplete penetrance J:30828
Otx2tm1Sla/Otx2tm1Sla
involves: 129S1/Sv * 129X1/SvJ 		abnormal primitive streak elongation J:74124
abnormal primitive streak formation J:74124
abnormal rostral-caudal axis patterning J:74124
Otx2tm1Sla/Otx2tm1Sla
involves: 129S1/Sv * 129X1/SvJ * CD-1 		abnormal allantois morphology J:30828
abnormal axial mesoderm morphology J:30828
abnormal brain development J:30828
abnormal developmental patterning J:30828
abnormal ectoderm development J:30828
abnormal gastrulation J:30828
abnormal mesoderm development J:30828
abnormal neural tube morphology J:30828
abnormal notochord morphology J:30828
abnormal primitive streak formation J:30828
abnormal somite shape J:30828
abnormal visceral yolk sac endoderm morphology J:30828
abnormal visceral yolk sac mesenchyme morphology J:30828
abnormal visceral yolk sac morphology J:30828
absent forebrain J:30828
absent metencephalon J:30828
absent midbrain J:30828
absent prechordal mesoderm J:30828
decreased embryo size J:30828
embryonic growth retardation J:30828
embryonic lethality during organogenesis, complete penetrance J:30828
embryonic-extraembryonic boundary constriction J:30828
fused somites J:30828
impaired somite development J:30828
rostral body truncation J:30828
Otx2tm1Sla/Otx2tm2Sla
involves: 129S1/Sv * 129X1/SvJ * CD-1 		abnormal hindbrain development J:46641
absent forebrain J:46641
absent midbrain J:46641
Otx2tm2.1Imat/Otx2tm2.1Imat
involves: C57BL/6 * CBA 		abnormal rostral-caudal axis patterning J:64866
acephaly J:64866
Otx2tm2.1Imat/Otx2tm7Sia
involves: C57BL/6NCrlj * CBA/JNCrlj 		abnormal forebrain development J:91012
absent forebrain J:91012
absent midbrain J:91012
normal embryo phenotype J:91012
Otx2tm2Asim/Otx2tm2Asim
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		abnormal brain development J:71034
abnormal forebrain development J:71034
abnormal midbrain development J:71034
abnormal motor capabilities/coordination/movement J:71034
anencephaly J:71034
decreased forebrain size J:71034
decreased midbrain size J:71034
exencephaly J:71034
microcephaly J:71034
open neural tube J:71034
reduced fertility J:71034
Otx2tm3Tlam/Otx2tm3Tlam
129/Sv-Otx2tm3Tlam 		abnormal brain development J:130649
abnormal diencephalon morphology J:130649
abnormal facial morphology J:130649
abnormal midbrain morphology J:130649
postnatal lethality, incomplete penetrance J:130649
Otx2tm4.1Sia/Otx2tm4.1Sia
involves: C57BL/6 * CBA 		no abnormal phenotype detected J:74631
Otx2tm4.2Sia/Otx2+
involves: C57BL/6 * CBA * FVB/N 		no abnormal phenotype detected J:74631
Otx2tm4Sia/Otx2tm4Sia
involves: C57BL/6 * CBA 		perinatal lethality, incomplete penetrance J:74631
postnatal lethality, complete penetrance J:74631
Otx2tm5Sia/Otx2tm5Sia
involves: C57BL/6NCrlj * CBA/JNCrlj 		normal nervous system phenotype J:91011
Otx2tm6Asim/Otx2tm11Asim
Slc6a3tm1.1(cre)Bkmn/Slc6a3+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ 		abnormal neuron differentiation J:166896
increased susceptibility to dopaminergic neuron neurotoxicity J:166896
Otx2tm6Sia/Otx2tm6Sia
involves: C57BL/6NCrlj * CBA/JNCrlj 		normal nervous system phenotype J:91011
Otx2tm7Sia/Otx2+
Tg(Lefty2-cre)21bHmd/?
involves: C57BL/6NCrlj * CBA/JNCrlj 		normal embryo phenotype J:91012
Otx2tm7Sia/Otx2tm7Sia
involves: C57BL/6NCrlj * CBA/JNCrlj 		normal embryo phenotype J:91012
normal nervous system phenotype J:91012
Otx2tm8.2Sia/Otx2tm8.2Sia
involves: C57BL/6 * CBA 		abnormal brain development J:166617
abnormal cerebral cortex morphology J:166617
Otx2tm8Asim/Otx2tm8Asim
involves: 129P2/OlaHsd 		no abnormal phenotype detected J:153562
normal reproductive system phenotype J:153562
Otx2tm9Asim/Otx2tm9Asim
involves: 129P2/OlaHsd 		abnormal craniofacial morphology J:153562
abnormal forebrain development J:153562
abnormal midbrain development J:153562
acephaly J:153562
exencephaly J:153562
Otx2tm9Asim/Otx2tm10Asim
involves: 129P2/OlaHsd 		normal embryo phenotype J:153562
Otx2tm9Asim/Otx2tm11Asim
involves: 129P2/OlaHsd 		abnormal forebrain development J:153562
abnormal midbrain development J:153562
acephaly J:153562
Otx2tm9Sia/Otx2tm9Sia
involves: C57BL/6NCrlj * CBA/JNCrlj 		abnormal embryonic neuroepithelium morphology J:207608
abnormal forebrain morphology J:207608
Otx2tm10Asim/Otx2tm10Asim
involves: 129P2/OlaHsd 		abnormal embryo development J:153562
abnormal forebrain morphology J:153562
abnormal head morphology J:153562
Otx2tm10Asim/Otx2tm11Asim
involves: 129P2/OlaHsd 		abnormal embryo development J:153562
abnormal head morphology J:153562
Otx2tm10Sia/Otx2tm10Sia
involves: C57BL/6NCrlj * CBA/JNCrlj 		abnormal embryonic neuroepithelium morphology J:207608
abnormal forebrain morphology J:207608
Otx2tm11Asim/Otx2+
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		abnormal cone electrophysiology J:207121
abnormal retina bipolar cell morphology J:207121
abnormal retina horizontal cell morphology J:207121
abnormal rod electrophysiology J:207121
decreased retina cone cell number J:207121
decreased visual acuity J:207121
thin retina inner nuclear layer J:207121
normal vision/eye phenotype J:207121
Otx2tm11Asim/Otx2tm11Asim
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		embryonic lethality during organogenesis, complete penetrance J:207121
Otx2tm12.1Asim/Otx2+
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		abnormal rod electrophysiology J:207121
decreased retina cone cell number J:207121
decreased retina ganglion cell number J:207121
thin retina inner nuclear layer J:207121
thin retina outer nuclear layer J:207121
normal vision/eye phenotype J:207121
Otx2tm12.1Asim/Otx2tm11Asim
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		abnormal head morphology J:207121
forebrain hypoplasia J:207121
midbrain hypoplasia J:207121
neonatal lethality, complete penetrance J:207121
Otx2tm12.1Asim/Otx2tm12.1Asim
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		abnormal cone electrophysiology J:207121
abnormal iris morphology J:207121
abnormal optic nerve morphology J:207121
abnormal retina bipolar cell morphology J:207121
abnormal retina horizontal cell morphology J:207121
abnormal retina morphology J:207121
abnormal retina pigment epithelium morphology J:207121
abnormal rod electrophysiology J:207121
anophthalmia J:207121
decreased retina cone cell number J:207121
decreased retina ganglion cell number J:207121
decreased retina photoreceptor cell number J:207121
decreased visual acuity J:207121
microphthalmia J:207121
normal mortality/aging J:207121
normal nervous system phenotype J:207121
thin retina inner nuclear layer J:207121
thin retina outer nuclear layer J:207121
normal vision/eye phenotype J:207121
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11/12/2024
MGI 6.24 		The Jackson Laboratory