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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Otx2
orthodenticle homeobox 2
MGI:97451
117 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ctnnb1tm2.1Kem/Ctnnb1+
Otx2tm1(Dkk1)Imat/Otx2tm1(Dkk1)Imat
involves: 129/Sv * C57BL/6 * CBA 		abnormal rostral-caudal axis patterning J:103272
Emx1tm1Sia/Emx1tm1Sia
Otx2tm1Sia/Otx2+
involves: C57BL/6 * CBA 		normal nervous system phenotype J:98539
Emx2tm1Sia/Emx2+
Otx2tm1Sia/Otx2+
involves: C57BL/6 * CBA 		abnormal forebrain morphology J:70745
Emx2tm1Sia/Emx2tm1Sia
Otx2tm1Sia/Otx2+
involves: C57BL/6 * CBA 		abnormal adenohypophysis morphology J:70745
abnormal Ammon gyrus morphology J:70745
abnormal anterior commissure morphology J:70745
abnormal cerebral cortex morphology J:70745, J:98539
abnormal corpus callosum morphology J:70745
abnormal forebrain development J:163926
abnormal forebrain morphology J:70745
abnormal hippocampal fornix morphology J:70745
abnormal hippocampus region morphology J:70745
abnormal lateral ganglionic eminence morphology J:70745
abnormal lens morphology J:70745
abnormal medial ganglionic eminence morphology J:70745
abnormal midbrain morphology J:70745
abnormal midbrain-hindbrain boundary morphology J:70745
abnormal olfactory bulb mitral cell layer morphology J:70745
abnormal olfactory sensory neuron morphology J:70745
abnormal posterior commissure morphology J:70745
abnormal pretectal region morphology J:70745
abnormal telencephalon morphology J:70745, J:98539
abnormal thalamus morphology J:70745
absent choroid plexus J:70745, J:98539
absent dentate gyrus J:70745
absent hippocampal fimbria J:70745
absent hippocampus J:70745, J:98539
enlarged tectum J:70745
lethality throughout fetal growth and development, complete penetrance J:70745
retina hyperplasia J:70745
small olfactory bulb J:70745
Emx2tm1Sia/Emx2tm1Sia
Otx2tm7Sia/Otx2tm7Sia
involves: C57BL/6NCrlj * CBA/JNCrlj 		absent diencephalon J:91012
Gbx2tm1.1Mrt/Gbx2tm1.1Mrt
Otx2tm1(OTX1)Asim/Otx2tm1(OTX1)Asim
involves: 129 * C57BL/6 * DBA/2 		abnormal embryonic neuroepithelium morphology J:72725
abnormal heart morphology J:72725
abnormal neural plate morphology J:72725
abnormal neural tube morphology J:72725
absent embryonic telencephalon J:72725
absent midbrain-hindbrain boundary J:72725
absent nasal placodes J:72725
absent optic placodes J:72725
absent optic vesicle J:72725
absent pharyngeal arches J:72725
decreased embryo size J:72725
dilated heart J:72725
embryonic lethality during organogenesis, complete penetrance J:72725
exencephaly J:72725
Gbx2tm1.1Mrt/Gbx2tm1.1Mrt
Otx2tm1Pas/Otx2tm2Asim
involves: 129 * C57BL/6 * DBA/2 		abnormal brain development J:72725
abnormal head development J:72725
normal cardiovascular system phenotype J:72725
normal mortality/aging J:72725
Gdf7tm3(cre)Tmj/Gdf7+
Otx2tm6Asim/Otx2tm6Asim
Tg(CAG-cat,-EGFP)1Rbns/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal cerebral cortex morphology J:194049
abnormal choroid plexus morphology J:194049
abnormal nervous system physiology J:194049
Gt(ROSA)26Sortm1.1(Otx2)Daac/Gt(ROSA)26Sortm1.1(Otx2)Daac
Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Tg(CAG-Otx2,-GFP)21Asim/0
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		decreased dopaminergic neuron number J:166896
decreased susceptibility to dopaminergic neuron neurotoxicity J:166896
Otx1tm1Asim/Otx1tm1Asim
Otx2tm1Pas/Otx2+
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		abnormal dopaminergic neuron morphology J:88192
abnormal neuron morphology J:88192
abnormal serotonergic neuron morphology J:88192
Otx1tm1Asim/Otx1tm2(otd)Asim
Otx2tm1Pas/Otx2+
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		abnormal brain morphology J:47899
abnormal cerebellum morphology J:47899
abnormal midbrain morphology J:47899
perinatal lethality, complete penetrance J:47899
Otx1tm1Sia/Otx1+
Otx2tm1Sia/Otx2+
involves: C57BL/6 * CBA 		abnormal brain development J:51989
abnormal cartilage morphology J:73592
abnormal cerebral cortex morphology J:73592
abnormal cerebral hemisphere morphology J:51989
abnormal cranium morphology J:73592
abnormal diencephalon morphology J:73592
abnormal forebrain morphology J:51989
abnormal hypothalamus morphology J:73592
abnormal inferior colliculus morphology J:73592
abnormal mammillary body morphology J:73592
abnormal metencephalon morphology J:51989
abnormal midbrain morphology J:51989, J:73592
abnormal midbrain-hindbrain boundary morphology J:51989
abnormal nervous system morphology J:73592
abnormal oculomotor nerve morphology J:73592
abnormal oculomotor nucleus morphology J:73592
abnormal optic nerve morphology J:73592
abnormal orbitosphenoid bone morphology J:73592
abnormal posterior commissure morphology J:73592
abnormal pretectal region morphology J:51989
abnormal red nucleus morphology J:73592
abnormal rhombic lip morphology J:73592
abnormal sphenoid bone morphology J:73592
abnormal superior colliculus morphology J:73592
abnormal tegmentum morphology J:73592
abnormal telencephalon morphology J:51989, J:73592
abnormal trigeminal V mesencephalic nucleus morphology J:73592
abnormal trochlear nerve morphology J:73592
basisphenoid bone foramen J:73592
decreased midbrain size J:73592
decreased substantia nigra size J:73592
enlarged cerebellum J:51989, J:73592
enlarged cerebral aqueduct J:73592
increased pons size J:51989
prenatal lethality, complete penetrance J:73592
presphenoid bone hypoplasia J:73592
small hippocampus J:51989, J:73592
small olfactory bulb J:73592
small thalamus J:51989, J:73592
Otx1tm1Sia/Otx1+
Otx2tm2(Otx1)Sia/Otx2+
involves: C57BL/6 * CBA 		abnormal midbrain-hindbrain boundary morphology J:51989
decreased midbrain size J:51989
increased rhombomere 1 size J:51989
Otx1tm1Sia/Otx1tm1Sia
Otx2tm5Sia/Otx2tm5Sia
involves: C57BL/6NCrlj * CBA/JNCrlj 		abnormal brain development J:91011
absent diencephalon J:91011
absent midbrain J:91011
Otx1tm1Sia/Otx1tm1Sia
Otx2tm8.2Sia/Otx2tm8.2Sia
involves: C57BL/6 * CBA 		abnormal cerebral cortex morphology J:166617
abnormal embryonic/fetal subventricular zone morphology J:166617
abnormal midbrain-hindbrain boundary morphology J:166617
absent diencephalon J:166617
absent midbrain J:166617
absent tectum J:166617
absent tegmentum J:166617
increased pons size J:166617
Otx1tm1Sia/Otx1tm1Sia
Otx2tm10Sia/Otx2tm10Sia
involves: C57BL/6NCrlj * CBA/JNCrlj 		abnormal embryonic neuroepithelium morphology J:207608
Otx1tm2(otd)Asim/Otx1tm2(otd)Asim
Otx2tm1Pas/Otx2+
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		abnormal midbrain morphology J:47899
Otx2tm1(Dkk1)Imat/Otx2tm1(Dkk1)Imat
involves: C57BL/6 * CBA 		abnormal rostral-caudal axis patterning J:103272
Otx2tm1(OTX1)Asim/Otx2tm1(OTX1)Asim
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		abnormal anterior head development J:49817
abnormal cephalic neural fold morphology J:49817
abnormal craniofacial development J:49817
abnormal embryonic neuroepithelium morphology J:49817
abnormal first pharyngeal arch morphology J:49817
abnormal forebrain development J:49817
abnormal maxillary prominence morphology J:49817
abnormal midbrain development J:49817
acephaly J:49817
rostral body truncation J:49817
Otx2tm1.1(cre/ERT2)Mgoe/Otx2tm6Asim
Tg(CAG-cat,-EGFP)1Rbns/0
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 		abnormal choroid plexus morphology J:194049
absent choroid plexus J:194049
Otx2tm2(Otx1)Sia/Otx2+
involves: C57BL/6 * CBA 		abnormal eye morphology J:51989
abnormal mandible morphology J:51989
normal craniofacial phenotype J:51989
Otx2tm2(Otx1)Sia/Otx2tm2(Otx1)Sia
involves: C57BL/6 * CBA 		abnormal brain development J:51989
abnormal forebrain development J:51989
abnormal midbrain development J:51989
absent maxilla J:51989
absent olfactory bulb J:51989
absent pituitary gland J:51989
anophthalmia J:51989
normal embryo phenotype J:51989
neonatal lethality, complete penetrance J:51989
otocephaly J:51989
small mandible J:51989
Otx2tm3(Emx2)Sia/Otx2+
involves: C57BL/6 * CBA 		abnormal pretectal region morphology J:70745
Otx2tm3(otd)Asim/Otx2tm3(otd)Asim
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		abnormal forebrain development J:72726
abnormal head morphology J:72726
abnormal midbrain-hindbrain boundary development J:72726
acephaly J:72726
exencephaly J:72726
Otx2tm4(otd)Asim/Otx2tm4(otd)Asim
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		abnormal first pharyngeal arch morphology J:72726
abnormal maxillary prominence morphology J:72726
acephaly J:72726
decreased body size J:72726
Otx2tm5(OTX2)Asim/Otx2tm5(OTX2)Asim
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		abnormal forebrain development J:72726
abnormal head morphology J:72726
abnormal midbrain development J:72726
acephaly J:72726
Otx2tm7(OTX1)Asim/Otx2tm7(OTX1)Asim
involves: 129P2/OlaHsd * C57BL/6 * (C57BL/6 x DBA/2)F1 * DBA/2 		normal nervous system phenotype J:89361
no abnormal phenotype detected J:89361
Rr103tm3.1Sia/Rr103tm3.1Sia
Otx2tm1Sia/Otx2+
involves: C57BL/6 * CBA 		absent diencephalon J:163926
Rr103tm3Sia/Rr103tm3Sia
Otx2tm1Sia/Otx2+
involves: C57BL/6 * CBA 		absent diencephalon J:163926
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory