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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Pax3
paired box 3
MGI:97487
131 phenotypes from 28 alleles in 41 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Gt(ROSA)26Sortm2(Pax3)Joe/Gt(ROSA)26Sor+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA 		cleft palate J:137730
Gt(ROSA)26Sortm2(Pax3)Joe/Gt(ROSA)26Sor+
Pax3tm1(cre)Joe/Pax3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		decreased palatal length J:137730
normal limbs/digits/tail phenotype J:137730
normal muscle phenotype J:137730
Gt(ROSA)26Sortm2(Pax3)Joe/Gt(ROSA)26Sortm2(Pax3)Joe
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		no abnormal phenotype detected J:137730
Gt(ROSA)26Sortm2(Pax3)Joe/Gt(ROSA)26Sortm2(Pax3)Joe
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA 		abnormal craniofacial morphology J:137730
abnormal eyelid morphology J:137730
abnormal palate morphology J:137730
Gt(ROSA)26Sortm2(Pax3)Joe/Gt(ROSA)26Sortm2(Pax3)Joe
Pax3tm1(cre)Joe/Pax3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal bone mineralization J:137730
abnormal bone ossification J:137730
abnormal craniofacial bone morphology J:137730
abnormal eyelid development J:137730
abnormal forelimb morphology J:137730
abnormal osteoblast differentiation J:137730
abnormal pterygoid process morphology J:137730
abnormal secondary palate development J:137730
absent alisphenoid bone J:137730
absent eyelids J:137730
absent pterygoid process J:137730
alisphenoid bone hypoplasia J:137730
cleft palate J:137730
decreased tympanic ring size J:137730
failure of eyelid fusion J:137730
failure of palatal shelf elevation J:137730
hypaxial muscle hypoplasia J:137730
normal limbs/digits/tail phenotype J:137730
normal muscle phenotype J:137730
normal nervous system phenotype J:137730
postnatal lethality J:137730
Gt(ROSA)26Sortm2(Pax3)Joe/Gt(ROSA)26Sortm2(Pax3)Joe
Pax3tm1(cre)Joe/Pax3tm1(cre)Joe
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		postnatal lethality J:137730
Pax3M1Btlr/Pax3M1Btlr
C57BL/6J-Pax3M1Btlr 		variable body spotting J:221484
Pax3m2Btlr/Pax3m2Btlr
C57BL/6J-Pax3M2Btlr 		variable body spotting J:234261
Pax3Rwa/Pax3+
B6N.Cg-Pax3Rwa 		abnormal hind foot hair pigmentation J:241031
abnormal tail hair pigmentation J:241031
abnormal ventral coat pigmentation J:241031
belly spot J:241031
curly tail J:241031
spina bifida J:241031
transverse fur striping J:241031
Pax3Rwa/Pax3Rwa
B6N.Cg-Pax3Rwa 		abnormal embryo morphology J:241031
decreased embryo size J:241031
embryonic lethality J:241031
open neural tube J:241031
Pax3Sp-1H/Pax3Sp-1H
involves: 101/H * C3H * C3H/HeH 		abnormal lateral ventricle morphology J:19818
exencephaly J:19818
incomplete rostral neuropore closure J:19818
Pax3Sp-1H/Pax3Sp-1H
involves: 101/H * C3H/HeH * C57BL/6 		abnormal common carotid artery morphology J:88412
abnormal dorsal root ganglion morphology J:88412
abnormal pharyngeal arch artery morphology J:88412
abnormal sixth pharyngeal arch artery morphology J:88412
abnormal spinal cord morphology J:88412
abnormal thymus morphology J:88412
abnormal thyroid gland morphology J:88412
absent thyroid gland J:88412
absent ultimobranchial body J:88412
common truncal valve J:88412
double outlet right ventricle J:88412
lethality throughout fetal growth and development, complete penetrance J:88412
open neural tube J:88412
persistent right dorsal aorta J:88412
persistent truncus arteriosus J:88412
retroesophageal right subclavian artery J:88412
small thyroid gland J:88412
Pax3Sp-1Wli/Pax3+
involves: C57BL/6J * CBA/CaJ 		belly spot J:196572
white spotting J:196572
Pax3Sp-1Wli/Pax3Sp-1Wli
involves: C57BL/6J * CBA/CaJ 		abnormal neural tube morphology J:196572
embryonic lethality during organogenesis, incomplete penetrance J:196572
exencephaly J:196572
prenatal lethality, complete penetrance J:196572
spina bifida J:196572
Pax3Sp-1Xzg/Pax3+
C57BL/6J-Pax3Sp-1Xzg 		belly spot J:196566
curly tail J:196566
decreased tail pigmentation J:196566
hypopigmentation J:196566
white spotting J:196566
Pax3Sp-1Xzg/Pax3Sp-1Xzg
C57BL/6J-Pax3Sp-1Xzg 		abnormal limb morphology J:196566
embryonic lethality during organogenesis, complete penetrance J:196566
exencephaly J:196566
open neural tube J:196566
spina bifida J:196566
Pax3Sp-2H/Pax3+
involves: 101 * C3H/He * CBA/Ca 		belly spot J:46341
Pax3Sp-2H/Pax3+
involves: C57BL/6 		belly spot J:14096
diluted coat color J:14096
Pax3Sp-2H/Pax3Sp-2H
involves: 101 * C3H/He 		abnormal myocardial fiber physiology J:46341
abnormal neural fold elevation formation J:46341
decreased heart left ventricle muscle contractility J:46341
dilated heart left ventricle J:46341
dilated heart right ventricle J:46341
exencephaly J:46341
lethality throughout fetal growth and development, incomplete penetrance J:46341
open neural tube J:46341
persistent truncus arteriosus J:46341
ventricular septal defect J:46341
Pax3Sp-2H/Pax3Sp-2H
involves: 101 * C3H/He * CBA/Ca 		abnormal myocardial fiber physiology J:46341
abnormal neural fold elevation formation J:46341
abnormal neural tube morphology J:60939
decreased heart left ventricle muscle contractility J:46341
dilated heart left ventricle J:46341
dilated heart right ventricle J:46341
exencephaly J:46341, J:60939
lethality throughout fetal growth and development, incomplete penetrance J:46341
open neural tube J:46341, J:60939
persistent truncus arteriosus J:46341
spina bifida J:60939
ventricular septal defect J:46341
Pax3Sp-2H/Pax3Sp-2H
involves: C57BL/6 		abnormal dermomyotome development J:32016
abnormal muscle precursor cell migration J:32016
abnormal myogenesis J:18227, J:32016
prenatal lethality, complete penetrance J:14096
spina bifida J:14096
Pax3Sp-2H/Pax3Sp-2H
involves: DBA/2 		exencephaly J:60939
open neural tube J:60939
spina bifida J:60939
Pax3Sp-2H/Pax3Sp-2H
involves: NZW 		exencephaly J:60939
open neural tube J:60939
spina bifida J:60939
Pax3Sp-2J/Pax3+
C3H/HeJ-Pax3Sp-2J 		belly spot J:238
head spot J:238
Pax3Sp-2J/Pax3+
involves: C3H/HeJ * C57BL/6J 		belly spot J:238
Pax3Sp-2J/Pax3Sp-2J
either: C3H/HeJ-Pax3Sp-2J or (involves: C3H/HeJ * C57BL/6J) 		prenatal lethality, complete penetrance J:238
Pax3Sp-3J/Pax3+
involves: C57BL/6J 		belly spot J:238
Pax3Sp-5H/Pax3Sp-5H
involves: 101/H * C3H/HeH 		decreased body size J:27501
embryonic lethality, incomplete penetrance J:27502
normal nervous system phenotype J:27502
white spotting J:27501
Pax3Sp-6H/Pax3Sp-6H
involves: 101/H * C3H/HeH 		decreased body size J:27501
white spotting J:27501
Pax3Sp-7H/Pax3+
involves: C3H/HeH * C57BL/6 		abnormal coat/hair pigmentation J:93195
belly spot J:93195
Pax3Sp-7H/Pax3Sp-7H
involves: C3H/HeH * C57BL/6 		abnormal hindbrain morphology J:93195
abnormal neural crest cell migration J:93195
delayed neural tube closure J:93195
Pax3Sp-10J/Pax3+
C57BL/6J-Pax3Sp-10J/GrsrJ 		belly spot J:162227
curly tail J:162227
normal vision/eye phenotype J:162227
white spotting J:162227
Pax3Sp-10J/Pax3Sp-10J
C57BL/6J-Pax3Sp-10J/GrsrJ 		prenatal lethality, complete penetrance J:162227
Pax3Sp-d/Pax3+
C57BL/6J-Pax3Sp-d 		belly spot J:238
Pax3Sp-d/Pax3Sp-d
C57BL/6J-Pax3Sp-d 		abnormal dorsal root ganglion morphology J:70476
abnormal neural tube morphology J:70476
caudal rachischisis J:238
curly tail J:70476
disorganized dorsal root ganglion J:70476
exencephaly J:70476
perinatal lethality, complete penetrance J:238
spina bifida J:70476
Pax3Sp-J/Pax3+
C57BL/6J-Pax3Sp-J 		belly spot J:238
Pax3Sp/Pax3+
C57BL-Pax3Sp 		belly spot J:12957
white spotting J:12957
Pax3Sp/Pax3+
involves: C3HeB * C57BL * C57BL/6J * SWV 		spina bifida J:114747
Pax3Sp/Pax3+
involves: C57BL * C57BL/6J * CBA 		normal hearing/vestibular/ear phenotype J:2179
Pax3Sp/Pax3Sp
BR.B-Pax3Sp 		perinatal lethality, complete penetrance J:11996
spina bifida cystica J:11996
Pax3Sp/Pax3Sp
C57BL-Pax3Sp 		abnormal brain ventricle morphology J:13016
abnormal dorsal root ganglion morphology J:13016
abnormal midbrain development J:5443, J:13016
abnormal neural tube morphology J:6190, J:13016
abnormal tail morphology J:13016
absent coat pigmentation J:13016
absent skin pigmentation J:13016
increased mitotic index J:13016
kinked tail J:12957
lethality throughout fetal growth and development, complete penetrance J:12957
open neural tube J:5443, J:13016
small embryonic telencephalon J:13016
spina bifida J:12957
Pax3Sp/Pax3Sp
involves: 129S2/SvPas * C57BL * C57BL/6J * FVB 		increased embryonic neuroepithelium apoptosis J:75569
open neural tube J:75569
Pax3Sp/Pax3Sp
involves: C57BL 		abnormal bony labyrinth J:114748
abnormal dermomyotome development J:32016, J:112275
abnormal endolymphatic duct morphology J:114748
abnormal hypoglossal cord morphology J:112275
abnormal muscle precursor cell migration J:32016
abnormal myogenesis J:18227, J:32016, J:112275
abnormal otic vesicle development J:114748
abnormal semicircular canal morphology J:114748
abnormal utricle morphology J:114748
abnormal vestibular saccule morphology J:114748
decreased cochlea coiling J:114748
embryonic lethality during organogenesis, complete penetrance J:11996
open neural tube J:114748
short endolymphatic duct J:114748
spina bifida J:110617, J:112275
Pax3tm1(cre)Joe/Pax3tm1(cre)Joe
Not Specified 		abnormal diaphragm development J:137730
abnormal hindlimb morphology J:137730
abnormal neural tube morphology J:137730
exencephaly J:137730
open neural tube J:137730
postnatal lethality, complete penetrance J:137730
thin diaphragm muscle J:137730
Pax3tm1(cre)Joe/Pax3tm2Joe
involves: 129S1/Sv * 129X1/SvJ 		no abnormal phenotype detected J:159124
Pax3tm1.1Sjc/Pax3+
involves: 129X1/SvJ * C3H * C57BL/6 		no abnormal phenotype detected J:75127
Pax3tm1.1Sjc/Pax3tm1.2Sjc
involves: 129X1/SvJ * C3H * C57BL/6 		belly spot J:75127
head spot J:75127
Pax3tm1.2Sjc/Pax3tm1.2Sjc
involves: 129X1/SvJ * C3H * C57BL/6 		embryonic lethality during organogenesis, complete penetrance J:75127
Pax3tm1Buck/Pax3+
involves: 129P2/OlaHsd 		belly spot J:86911
Pax3tm1Buck/Pax3Sp
involves: 129P2/OlaHsd * C57BL 		abnormal dermomyotome development J:86911
abnormal myogenesis J:86911
abnormal neural crest cell migration J:86911
absent dorsal root ganglion J:86911
exencephaly J:86911
open neural tube J:86911
prenatal lethality, complete penetrance J:86911
Pax3tm1Buck/Pax3tm1Buck
involves: 129P2/OlaHsd 		abnormal dermomyotome development J:176192
abnormal dorsal root ganglion morphology J:176192
abnormal muscle development J:176192
abnormal muscle precursor cell migration J:176192
abnormal myogenesis J:86911
abnormal myotome development J:176192
abnormal neural crest cell migration J:176192
abnormal neural tube morphology J:86911
abnormal somite development J:86911, J:176192
exencephaly J:176192
prenatal lethality, complete penetrance J:86911
spina bifida J:176192
Pax3tm1Buck/Pax3tm1Buck
involves: 129P2/OlaHsd * C57BL/6 		abnormal mammary line morphology J:109476
abnormal mammary placode morphology J:109476
abnormal somite development J:109476
Pax3tm2(PAX3/FOXO1A)Buck/Pax3+
involves: 129S2/SvPas 		belly spot J:86911
Pax3tm2.1(PAX3/FOXO1A)Buck/Pax3+
involves: 129S2/SvPas * BALB/c * C57BL/6 		abnormal dermomyotome development J:86911
abnormal intercostal muscle morphology J:86911
abnormal muscle development J:86911
abnormal myogenesis J:86911
abnormal myotome morphology J:86911
abnormal skeletal muscle morphology J:86911
abnormal somite border morphology J:86911
abnormal somite development J:86911
perinatal lethality, complete penetrance J:86911
rib fusion J:86911
Pax3tm2.1(PAX3/FOXO1A)Buck/Pax3Sp
involves: 129S2/SvPas * BALB/c * C57BL * C57BL/6 		abnormal muscle development J:86911
abnormal rib development J:86911
abnormal somite border morphology J:86911
prenatal lethality, complete penetrance J:86911
Pax3tm2.1Joe/Pax3tm2.1Joe
either: (involves: 129S1/Sv * 129X1/SvJ * BALB/cJ) or (involves: 129S1/Sv * 129X1/SvJ * FVB/N) 		no abnormal phenotype detected J:159124
Pax3tm2Joe/Pax3+
involves: 129S1/Sv * 129X1/SvJ 		belly spot J:159124
Pax3tm2Joe/Pax3tm2Joe
involves: 129S1/Sv * 129X1/SvJ 		abnormal cardiac outflow tract development J:159124
absent hypaxial muscle J:159124
exencephaly J:159124
persistent truncus arteriosus J:159124
prenatal lethality, complete penetrance J:159124
spina bifida J:159124
Pax3tm2Joe/Pax3tm2Joe
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J 		normal cardiovascular system phenotype J:159124
cyanosis J:159124
decreased birth body size J:159124
hypaxial muscle hypoplasia J:159124
neonatal lethality, complete penetrance J:159124
respiratory failure J:159124
spina bifida J:159124
Pax3tm3(Pax7)Buck/Pax3+
involves: 129S2/SvPas 		variable depigmentation J:90568
Pax3tm3(Pax7)Buck/Pax3tm3(Pax7)Buck
involves: 129S2/SvPas 		abnormal muscle development J:90568
abnormal neural crest cell migration J:90568
absent dorsal root ganglion J:90568
spina bifida J:90568
Pax3tm5.1Buck/Pax3+
involves: 129S2/SvPas * BALB/c * C57BL/6 		abnormal dermomyotome development J:112275
abnormal myogenesis J:112275
perinatal lethality, complete penetrance J:112275
spina bifida J:112275
Pax3tm6.2Buck/Pax3tm6.2Buck
involves: 129S2/SvPas * C57BL/6 * SJL 		exencephaly J:176192
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory