About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Pax3
paired box 3
MGI:97487
201 phenotypes from multigenic genotypes
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
a/a
Pax3Sp-1H/Pax3Sp-1H
involves: 101/H * C3H/HeH * C57BL/6 		abnormal cerebral cortex morphology J:19818
abnormal lateral ventricle morphology J:19818
absent choroid plexus J:19818
absent olfactory bulb J:19818
exencephaly J:19818
incomplete rostral neuropore closure J:19818
Arl13bhnn/Arl13btm1Tc
Pax3tm1(cre)Joe/Pax3+
involves: 129S6/SvEvTac * C57BL/6J 		decreased body size J:173637
perinatal lethality, incomplete penetrance J:173637
postnatal lethality, complete penetrance J:173637
respiratory distress J:173637
Bcortm1.1Vjba/Y
Pax3tm1(cre)Joe/Pax3+
involves: 129S1/Sv * C57BL/6J 		abnormal major salivary gland morphology J:296645
abnormal tongue morphology J:296645
abnormal tongue position J:296645
absent gastric milk in neonates J:296645
bifid tongue J:296645
normal cardiovascular system phenotype J:296645
complete cleft palate J:296645
decreased tympanic ring size J:296645
failure of palatal shelf elevation J:296645
neonatal lethality, complete penetrance J:296645
pallor J:296645
short mandible J:296645
short Meckel's cartilage J:296645
tongue ankylosis J:296645
Cdkn2atm4Rdp/Cdkn2atm4Rdp
Myf6tm1(cre)Mrc/Myf6+
Pax3tm1Mrc/Pax3tm1Mrc
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		increased rhabdomyosarcoma incidence J:93444
Ctnnb1tm4Wbm/Ctnnb1tm4Wbm
Pax3tm1(cre)Joe/Pax3+
Not Specified 		abnormal neural tube morphology J:96431
Dkk1tm1.1Svo/Dkk1tm1.2Svo
Pax3tm1(cre)Joe/Pax3+
involves: 129P2/OlaHsd * C57BL/6 * SJL 		abnormal craniofacial development J:173125
caudal body truncation J:173125
perinatal lethality, complete penetrance J:173125
normal renal/urinary system phenotype J:173125
Egln1tm2.1Fsl/Egln1+
Pax3tm1(cre)Joe/Pax3+
involves: 129 * C57BL/6 		increased hematocrit J:202737
polycythemia J:202737
Egln1tm2.1Fsl/Egln1tm2.1Fsl
Pax3tm1(cre)Joe/Pax3+
involves: 129 * C57BL/6 		abnormal liver vasculature morphology J:202737
increased heart weight J:202737
increased hematocrit J:202737
increased liver weight J:202737
increased spleen weight J:202737
polycythemia J:202737
Elmo1tm1.2Ravi/Elmo1tm1.2Ravi
Elmo2tm1c(EUCOMM)Hmgu/Elmo2tm1c(EUCOMM)Hmgu
Pax3tm1(cre)Joe/Pax3+
involves: 129P2/OlaHsd * C57BL/6N 		abnormal diaphragm development J:331473
abnormal muscle development J:331473
lethality during fetal growth through weaning, complete penetrance J:331473
Elmo2tm1c(EUCOMM)Hmgu/Elmo2tm1c(EUCOMM)Hmgu
Pax3tm1(cre)Joe/Pax3+
involves: 129 * C57BL/6N 		preweaning lethality, incomplete penetrance J:331473
Ets1tm1Most/Ets1tm1Most
Pax3tm1(cre)Joe/Pax3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		double outlet right ventricle J:334073
Ets1tm2Jml/Ets1tm2Jml
Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+
Pax3tm1(cre)Joe/Pax3+
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * C57BL/6NCrl 		abnormal cardiac neural crest cell migration J:334073
abnormal cardiac outflow tract development J:334073
abnormal conotruncal ridge morphology J:334073
abnormal neural crest cell physiology J:334073
double outlet right ventricle J:334073
Fat1tm1Fhel/Fat1tm1Fhel
Pax3tm1(cre)Joe/Pax3+
Tg(Myl1-lacZ)1Ibdml/0
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL 		abnormal muscle development J:199157
abnormal skeletal muscle morphology J:199157
ectopic skeletal muscle J:199157
Fignfi/Fignfi
Pax3Sp/Pax3Sp
BR.Cg-Pax3Sp Fignfi 		open neural tube J:11996
prenatal lethality, complete penetrance J:11996
Foxo1tm1Mrc/Foxo1tm1Mrc
Myf6tm1(cre)Mrc/Myf6+
Pax3tm1Mrc/Pax3tm1Mrc
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		normal neoplasm J:93444
Gata4tm1.1Sad/Gata4tm1.2Sad
Pax3Sp-d/Pax3Sp-d
Tg(Prrx1-cre)1Cjt/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J 		normal muscle phenotype J:231793
normal respiratory system phenotype J:231793
Gata4tm1.1Sad/Gata4tm1.2Sad
Pax3tm1(cre)Joe/Pax3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		normal muscle phenotype J:231793
Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln/Gt(ROSA)26Sor+
Pax3Sp/Pax3+
Tg(Pax3-cre)1Joe/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		abnormal coat/hair pigmentation J:231654
abnormal enteric ganglia morphology J:231654
abnormal tail hair pigmentation J:231654
belly spot J:231654
Gt(ROSA)26Sortm1(MAML1)Wsp/Gt(ROSA)26Sor+
Pax3tm1(cre)Joe/Pax3+
Not Specified 		abnormal neural tube morphology J:130251
decreased neuronal precursor cell number J:130251
loss of glutamate neurons J:130251
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Pax3Sp-d/Pax3Sp-d
Tg(Prrx1-cre)1Cjt/0
involves: 129S4/SvJaeSor * C57BL/6J * SJL/J 		abnormal diaphragm morphology J:231793
Gt(ROSA)26Sortm2(SS18)Mrc/Gt(ROSA)26Sortm2(SS18)Mrc
Pax3tm1(cre)Joe/Pax3tm1(cre)Joe
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		embryonic lethality during organogenesis, complete penetrance J:120967
Gt(ROSA)26Sortm3(SS18/EGFP)Mrc/Gt(ROSA)26Sortm3(SS18/EGFP)Mrc
Pax3tm1(cre)Joe/Pax3tm1(cre)Joe
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		embryonic lethality during organogenesis, complete penetrance J:120967
Gt(ROSA)26Sortm4(EWSR1/ATF1)Mrc/Gt(ROSA)26Sor+
Pax3tm1(cre)Joe/Pax3+
involves: C57BL/6 		embryonic lethality, complete penetrance J:194308
Itm2atm1.1Buck/Y
Pax3tm1(cre)Joe/Pax3+
involves: C57BL/6 		no abnormal phenotype detected J:200546
Itm2atm1.1Buck/Y
Pax3tm1(cre)Joe/Pax3tm1(cre)Joe
involves: C57BL/6 		abnormal neural tube morphology J:200546
Itm2atm1.2Buck/Y
Pax3tm4Buck/Pax3tm4Buck
involves: C57BL/6 		abnormal neural tube morphology J:200546
KitWps/Kit+
Pax3Sp-1Wli/Pax3+
involves: C57BL/6J * CBA/CaJ 		belly spot J:196572
white spotting J:196572
Lbx1tm1Thbr/Lbx1tm1Thbr
Pax3Sp-1H/Pax3Sp-1H
involves: 101/H * 129S4/SvJae * C3H/HeH * C57BL/6 		open neural tube J:78622
Lbx2tm1Fchn/Lbx2tm1Fchn
Pax3Sp/Pax3Sp
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal cranial ganglia morphology J:121890
abnormal dorsal root ganglion morphology J:121890
edema J:121890
exencephaly J:121890
open neural tube J:121890
Men1tm1.2Ctre/Men1+
Pax3tm1(cre)Joe/Pax3+
involves: 129S6/SvEvTac 		no abnormal phenotype detected J:127545
Men1tm1.2Ctre/Men1tm1.2Ctre
Pax3tm1(cre)Joe/Pax3+
involves: 129S6/SvEvTac 		abnormal basisphenoid bone morphology J:127545
abnormal palatal mesenchymal cell differentiation J:127545
abnormal palatal mesenchymal cell proliferation J:127545
abnormal palatal shelf bone ossification J:127545
abnormal pterygoid process morphology J:127545
abnormal rib development J:127545
abnormal rib morphology J:127545
abnormal secondary palate development J:127545
abnormal snout morphology J:127545
abnormal sternum morphology J:127545
abnormal sternum ossification J:127545
absent gastric milk in neonates J:127545
bilateral cleft palate J:127545
cleft secondary palate J:127545
cyanosis J:127545
meteorism J:127545
palatal shelf hypoplasia J:127545
palatal shelves fail to meet at midline J:127545
perinatal lethality, complete penetrance J:127545
primary atelectasis J:127545
respiratory distress J:127545
rib bifurcation J:127545
rib fusion J:127545
short snout J:127545
short soft palate J:127545
Men1tm1.2Ctre/Men1tm1.2Ctre
Pax3tm1(cre)Joe/Pax3+
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
involves: 129S4/SvJaeSor * 129S6/SvEvTac 		normal cardiovascular system phenotype J:127545
normal digestive/alimentary phenotype J:127545
Mettm1Cpo/Met+
Pax3tm2.1(PAX3/FOXO1A)Buck/Pax3+
involves: 129 * BALB/c * C57BL/6 		normal embryo phenotype J:86911
Mettm1Cpo/Mettm1Cpo
Pax3tm2.1(PAX3/FOXO1A)Buck/Pax3+
involves: 129 * BALB/c * C57BL/6 		normal embryo phenotype J:86911
Myf6tm1(cre)Mrc/Myf6+
Pax3tm1Mrc/Pax3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		increased rhabdomyosarcoma incidence J:93444
Myf6tm1(cre)Mrc/Myf6+
Pax3tm1Mrc/Pax3tm1Mrc
Trp53tm1Brn/Trp53+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		increased rhabdomyosarcoma incidence J:93444
Myf6tm1(cre)Mrc/Myf6+
Pax3tm1Mrc/Pax3tm1Mrc
Trp53tm1Brn/Trp53tm1Brn
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		increased rhabdomyosarcoma incidence J:93444
Myh3tm1.2Sajm/Myh3tm1.1Sajm
Pax3tm1(cre)Joe/Pax3+
involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6J 		abnormal muscle precursor cell morphology J:287755
Nf1tm1Fcr/Nf1tm1Par
Pax3tm1(cre)Joe/Pax3+
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ 		abnormal somatic sensory system morphology J:114455
adrenal medulla hyperplasia J:114455
neonatal lethality, complete penetrance J:114455
Notch2tm3Grid/Notch2tm3.1Grid
Pax3tm1(cre)Joe/Pax3+
involves: 129 * C57BL/6 		abnormal tooth morphology J:132939
abnormal vascular smooth muscle morphology J:132939
aorta stenosis J:132939
cyanosis J:132939
decreased body weight J:132939
postnatal lethality, incomplete penetrance J:132939
pulmonary artery stenosis J:132939
supravalvar pulmonary trunk stenosis J:132939
Nr2c2tm1Bbm/Nr2c2tm1Bbm
Pax3tm1(cre)Joe/Pax3+
Not Specified 		abnormal mechanical nociception J:197895
decreased neuron number J:197895
decreased pruritus J:197895
increased chemical nociceptive threshold J:197895
increased thermal nociceptive threshold J:197895
Pax3Sp-4H/Pax3+
involves: 101/H * C3H/HeH 		belly spot J:4295
prenatal lethality, incomplete penetrance J:4295
variable body spotting J:4295
Pax3Sp-4H/Pax3Sp-4H
involves: 101/H * C3H/HeH 		embryonic lethality between implantation and somite formation, complete penetrance J:33375
failure to gastrulate J:33375
Pax3Sp/Pax3Sp
Trp53tm1Tyj/Trp53+
involves: 129S2/SvPas * C57BL * C57BL/6J * FVB 		open neural tube J:75569
Pax3Sp/Pax3Sp
Trp53tm1Tyj/Trp53tm1Tyj
involves: 129S2/SvPas * C57BL * C57BL/6J * FVB 		normal nervous system phenotype J:75569
Pax3tm1(cre)Joe/Pax3+
Tbx5tm1Jse/Tbx5tm1Jse
Not Specified 		normal limbs/digits/tail phenotype J:157917
Pax3tm1(cre)Joe/Pax3+
Rbpjtm1Hon/Rbpjtm1Hon
involves: 129P2/OlaHsd 		abnormal diaphragm morphology J:120053
abnormal dorsal interneuron 4 morphology J:130251
abnormal epaxial muscle morphology J:120053
abnormal glutaminergic neuron morphology J:130251
abnormal intercostal muscle morphology J:120053
abnormal myogenesis J:120053
abnormal neural tube morphology J:130251
abnormal neuron differentiation J:130251
decreased neuronal precursor cell number J:130251
decreased satellite cell number J:120053
hypaxial muscle hypoplasia J:120053
loss of GABAergic neurons J:130251
neonatal lethality, complete penetrance J:120053
no spontaneous movement J:120053
respiratory failure J:120053
Pax3tm1(cre)Joe/Pax3+
Tg(CAG-Bgeo,-Spry2,-ALPP)1Mrt/0
Not Specified 		normal cardiovascular system phenotype J:143444
short mandible J:143444
short snout J:143444
Pax3tm1(FOXO1A)Gcg/Pax3+
either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * NMRI) 		abnormal diaphragm development J:79365
abnormal interventricular septum morphology J:79365
abnormal neural tube morphology J:79365
abnormal pulmonary alveolus morphology J:79365
abnormal skeletal muscle morphology J:79365
abnormal thymus lobule morphology J:79365
abnormal tongue muscle morphology J:79365
abnormal vena cava morphology J:79365
normal cardiovascular system phenotype J:79365
congestive heart failure J:79365
cyanosis J:79365
dilated pulmonary trunk J:79365
ectopic thymus J:79365
exencephaly J:79365
muscular ventricular septal defect J:79365
neonatal lethality, incomplete penetrance J:79365
normal neoplasm J:79365
patent tricuspid valve J:79365
respiratory distress J:79365
spina bifida J:79365
thick interventricular septum J:79365
thin ventricular wall J:79365
Pax3tm1.1Sjc/Pax3tm1.1Sjc
Pax7tm1.2Fan/Pax7tm1.2Fan
Tg(CAG-cre/Esr1*)5Amc/0
involves: 129 * C57BL/6 * CBA * SJL 		normal muscle phenotype J:150962
Pax3tm1Buck/Pax3tm1Buck
Pax7tm2Pgr/Pax7tm2Pgr
either: (involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ) or (involves: 129P2/OlaHsd * 129S2/SvPas) 		abnormal myotome development J:99365
prenatal lethality, complete penetrance J:99365
Pax3tm1Mrc/Pax3+
Tg(CMV-cre)1Cgn/?
involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 		abnormal cerebral cortex morphology J:93443
abnormal forebrain morphology J:93443
abnormal nasal bone morphology J:93443
abnormal sternum morphology J:93443
absent frontal bone J:93443
absent interparietal bone J:93443
absent olfactory bulb J:93443
absent parietal bone J:93443
absent premaxilla J:93443
anophthalmia J:93443
cranioschisis J:93443
exencephaly J:93443
forebrain hypoplasia J:93443
hypaxial muscle hypoplasia J:93443
maxilla hypoplasia J:93443
midbrain hyperplasia J:93443
omphalocele J:93443
optic placode degeneration J:93443
rib fusion J:93443
small dorsal root ganglion J:93443
thin diaphragm muscle J:93443
vertebral fusion J:93443
Pax3tm1Mrc/Pax3+
Pax7tm1(cre)Mrc/Pax7+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal nose morphology J:93443
abnormal premaxilla morphology J:93443
decreased body weight J:93443
decreased satellite cell number J:93443
decreased skeletal muscle fiber diameter J:93443
decreased skeletal muscle mass J:93443
increased skeletal muscle fiber density J:93443
lacrimal bone hypoplasia J:93443
maxilla hypoplasia J:93443
muscle hypoplasia J:93443
normal neoplasm J:93443
postnatal growth retardation J:93443
premature death J:93443
turbinate hypoplasia J:93443
Pax3tm1Mrc/Pax3tm1Mrc
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		no abnormal phenotype detected J:93444
Pax3tm3.1(Pax7)Buck/Pax3Sp
involves: 129S2/SvPas 		abnormal diaphragm development J:90568
abnormal myogenesis J:90568
decreased cell proliferation J:90568
normal integument phenotype J:90568
perinatal lethality, complete penetrance J:90568
spina bifida J:90568
Pax3tm3.1(Pax7)Buck/Pax3tm3.1(Pax7)Buck
involves: 129S2/SvPas 		abnormal diaphragm development J:90568
abnormal muscle development J:176192
abnormal muscle precursor cell migration J:90568
abnormal myogenesis J:90568
decreased cell proliferation J:90568
normal embryo phenotype J:176192
normal integument phenotype J:90568
normal nervous system phenotype J:90568
perinatal lethality, complete penetrance J:90568
Pax3tm5Buck/Pax3+
involves: 129S2/SvPas 		belly spot J:112275
Pax3tm6(Pax8)Buck/Pax3+
involves: 129S2/SvPas 		abnormal muscle development J:176192
abnormal myotome development J:176192
belly spot J:176192
Pax3tm6(Pax8)Buck/Pax3tm6(Pax8)Buck
involves: 129S2/SvPas 		abnormal neural crest cell migration J:176192
absent dorsal root ganglion J:176192
absent skeletal muscle J:176192
open neural tube J:176192
Pax3tm6.1(Pax8)Buck/Pax3+
involves: 129S2/SvPas * BALB/c * C57BL/6 		abnormal muscle development J:176192
abnormal myotome development J:176192
belly spot J:176192
Pax3tm6.1(Pax8)Buck/Pax3tm6.1(Pax8)Buck
involves: 129S2/SvPas * BALB/c * C57BL/6 		abnormal dermomyotome development J:176192
abnormal dorsal root ganglion morphology J:176192
abnormal muscle development J:176192
abnormal muscle precursor cell migration J:176192
abnormal myotome development J:176192
abnormal neural crest cell migration J:176192
abnormal neural tube morphology J:176192
abnormal somite development J:176192
absent skeletal muscle J:176192
exencephaly J:176192
lethality throughout fetal growth and development, complete penetrance J:176192
spina bifida J:176192
Pax3tm6.1(Pax8)Buck/Pax3tm6.2Buck
involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL 		abnormal muscle development J:176192
abnormal neural tube morphology J:176192
Rbfox2tm1.1Dblk/Rbfox2tm1.1Dblk
Pax3tm1(cre)Joe/0
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J 		abnormal axial skeleton morphology J:279139
abnormal craniofacial bone morphology J:279139
abnormal craniofacial morphology J:279139
abnormal frontal bone morphology J:279139
abnormal hypoglossal nerve morphology J:279139
abnormal nasal bone morphology J:279139
abnormal neurocranium morphology J:279139
abnormal oculomotor nerve morphology J:279139
abnormal palatal mesenchymal cell proliferation J:279139
abnormal rostral-caudal body axis extension J:279139
abnormal spine curvature J:279139
abnormal trochlear nerve morphology J:279139
absent palatine bone horizontal plate J:279139
atelectasis J:279139
normal cardiovascular system phenotype J:279139
cleft secondary palate J:279139
decreased bone ossification J:279139
ectopic bone J:279139
normal endocrine/exocrine gland phenotype J:279139
frontal bone hypoplasia J:279139
fusion of vertebral bodies J:279139
normal muscle phenotype J:279139
neonatal lethality, complete penetrance J:279139
palatal shelves fail to meet at midline J:279139
respiratory distress J:279139
respiratory failure J:279139
small mandible J:279139
small thoracic cavity J:279139
subcutaneous edema J:279139
thin dermal layer J:279139
Rbfox2tm1.1Dblk/Rbfox2tm1.1Dblk
Pax3tm1(cre)Joe/0
Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J 		normal cellular phenotype J:279139
normal embryo phenotype J:279139
Sp8tm1Smb/Sp8tm2Smb
Pax3tm1(cre)Joe/Pax3+
involves: 129S1/Sv * 129X1/SvJ 		abnormal face development J:200761
absent frontal bone J:200761
absent parietal bone J:200761
cleft palate J:200761
cleft upper lip J:200761
normal craniofacial phenotype J:200761
exencephaly J:200761
midline facial cleft J:200761
ocular hypertelorism J:200761
small snout J:200761
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory