Pbx1 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pbx1
pre B cell leukemia homeobox 1
MGI:97495

31 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Cdkn2b^tm1Bbd/Cdkn2b^tm1Bbd Pbx1^tm1Koss/Pbx1^tm1Koss Nkx2-5^tm2(cre)Rph/Nkx2-5⁺ involves: 129P2/OlaHsd * 129S1/Sv	abnormal spleen mesenchyme morphology	J:184521
	abnormal spleen morphology	J:184521
Gt(ROSA)26Sor^{tm2(Wnt1/GFP)Amc}/Gt(ROSA)26Sor⁺ Pbx1^tm1Koss/Pbx1^tm1Koss Pbx2^tm1Mlc/Pbx2⁺ Tg(Tcfap2a-cre)1Will/0 involves: 129P2/OlaHsd * 129S/Sv * 129X1/SvJ	normal craniofacial phenotype	J:178316
Pbx1^tm1Koss/Pbx1^tm1Koss Pbx2^tm1Mlc/Pbx2⁺ Foxg1^tm1(cre)Skm/Foxg1⁺ involves: 129P2/OlaHsd * 129S/Sv	abnormal maxillary shelf morphology	J:178316
	abnormal nasal capsule morphology	J:178316
	absent premaxilla	J:178316
	bilateral cleft upper lip	J:178316
	cleft palate	J:178316
	neonatal lethality, complete penetrance	J:178316
Pbx1^tm1Koss/Pbx1^tm1Koss Pbx2^tm1Mlc/Pbx2⁺ H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ involves: 129P2/OlaHsd * 129S/Sv * C57BL/6J * CBA/J	cleft palate	J:178316
	normal nervous system phenotype	J:178316
	postnatal lethality, complete penetrance	J:178316
Pbx1^tm1Koss/Pbx1^tm1Koss Pbx2^tm1Mlc/Pbx2⁺ Nkx2-5^tm2(cre)Rph/Nkx2-5⁺ involves: 129P2/OlaHsd * 129S/Sv * 129S1/Sv	abnormal spleen morphology	J:184521
	spleen hypoplasia	J:184521
Pbx1^tm1Koss/Pbx1^tm1Koss Pbx2^tm1Mlc/Pbx2⁺ Tg(Tcfap2a-cre)1Will/0 involves: 129P2/OlaHsd * 129S/Sv	cleft palate	J:178316
	cleft upper lip	J:178316
Pbx1^tm1Koss/Pbx1^tm1Koss Pbx2^tm1Mlc/Pbx2^tm1Mlc Foxg1^tm1(cre)Skm/Foxg1⁺ involves: 129P2/OlaHsd * 129S/Sv	bilateral cleft upper lip	J:178316
	decreased apoptosis	J:178316
Pbx1^tm1Koss/Pbx1^tm1Koss Pbx3^tm1Mlc/Pbx3⁺ Foxg1^tm1(cre)Skm/Foxg1⁺ involves: 129P2/OlaHsd	cleft palate	J:178316
	cleft upper lip	J:178316
Pbx1^tm1Koss/Pbx1^tm1Koss Pbx3^tm1Mlc/Pbx3⁺ Tg(Tcfap2a-cre)1Will/0 involves: 129P2/OlaHsd	cleft palate	J:178316
	cleft upper lip	J:178316
Pbx1^tm1Mlc/Pbx1⁺ Pbx2^tm1Mlc/Pbx2⁺ Pbx3^tm1Mlc/Pbx3⁺ involves: 129S6/SvEvTac	cleft palate	J:178316
	neonatal lethality, complete penetrance	J:178316
Pbx1^tm1Mlc/Pbx1⁺ Wnt9b^tm1Amc/Wnt9b^tm1Amc Foxg1^tm1(cre)Skm/Foxg1⁺ involves: 129P2/OlaHsd * 129S6/SvEvTac * 129X1/SvJ	bilateral cleft upper lip	J:178316
	cleft palate	J:178316
Pbx1^tm1Mlc/Pbx1^tm1Mlc Pbx2^tm1Mlc/Pbx2⁺ involves: 129S6/SvEvTac	abnormal lateral nasal prominence morphology	J:178316
	abnormal maxillary prominence morphology	J:178316
	abnormal medial nasal prominence morphology	J:178316
	bilateral cleft upper lip	J:178316
	cleft upper lip	J:178316
	edema	J:178316
	micrognathia	J:178316
	small snout	J:178316
	tongue hypoplasia	J:178316
	unilateral cleft upper lip	J:178316
Pbx1^tm1Mlc/Pbx1^tm1Mlc Pbx3^tm1Mlc/Pbx3⁺ involves: 129S6/SvEvTac	bilateral cleft palate	J:178316
	bilateral cleft upper lip	J:178316
	cleft palate	J:178316
	edema	J:178316
	micrognathia	J:178316
	small snout	J:178316
	tongue hypoplasia	J:178316
	unilateral cleft palate	J:178316
	unilateral cleft upper lip	J:178316
Pdx1^tm1Cvw/Pdx1⁺ Pbx1^tm1Mlc/Pbx1⁺ involves: 129S6/SvEvTac * C57BL/6	decreased insulin secretion	J:75811
	disorganized pancreatic islets	J:75811
	hyperglycemia	J:75811
	impaired glucose tolerance	J:75811
	increased insulin sensitivity	J:75811
	increased urine glucose level	J:75811
	weight loss	J:75811

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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