Pbx3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pbx3
pre B cell leukemia homeobox 3
MGI:97496

32 phenotypes from 5 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Hoxb1^tm1(cre)Og/Hoxb1⁺ Pbx3^tm1Og/Pbx3^tm1Og involves: 129S/SvEv * 129S4/SvJae * C57BL/6	abnormal behavior	J:130927
	abnormal limb posture	J:130927
	abnormal locomotor coordination	J:130927
	abnormal neuron differentiation	J:130927
	abnormal neuron morphology	J:130927
	abnormal spinal cord dorsal horn morphology	J:130927
	bradykinesia	J:130927
	decreased body size	J:130927
	decreased neuron number	J:130927
	decreased thermal nociceptive threshold	J:130927
	hyporesponsive to tactile stimuli	J:130927
	impaired coordination	J:130927
	improved righting response	J:130927
	increased startle reflex	J:130927
	limb grasping	J:130927
Pbx3^tm1.1Og/Pbx3^tm1.1Og involves: 129S4/SvJae * C57BL/6	cyanosis	J:130927
Pbx3^tm1.1Og/Pbx3^tm1.1Og involves: 129S4/SvJae * C57BL/6	neonatal lethality, complete penetrance	J:130927
Pbx3^{tm1a(EUCOMM)Wtsi}/Pbx3⁺ Not Specified	abnormal response to new environment	J:165965
Pbx3^{tm1a(EUCOMM)Wtsi}/Pbx3^{tm1a(EUCOMM)Wtsi} Not Specified	decreased bone mineral density	J:165965
	decreased circulating cholesterol level	J:165965
	increased bone mineral density	J:165965
	increased circulating cholesterol level	J:165965
	increased lean body mass	J:165965
Pbx3^{tm1b(EUCOMM)Wtsi}/Pbx3⁺ C57BL/6N-Pbx3^{tm1b(EUCOMM)Wtsi}/H	abnormal tooth morphology	J:211773
	absent ovary	J:211773
	decreased blood urea nitrogen level	J:211773
	decreased total body fat amount	J:211773
	increased circulating bilirubin level	J:211773
Pbx3^{tm1b(EUCOMM)Wtsi}/Pbx3^{tm1b(EUCOMM)Wtsi} C57BL/6N-Pbx3^{tm1b(EUCOMM)Wtsi}/H	preweaning lethality, complete penetrance	J:211773
Pbx3^tm1Mlc/Pbx3^tm1Mlc involves: C57BL/6	abnormal somatic nervous system physiology	J:93761
	cyanosis	J:93761
	hypoventilation	J:93761
	neonatal lethality, complete penetrance	J:93761
	respiratory failure	J:93761

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24