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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Pcsk4
proprotein convertase subtilisin/kexin type 4
MGI:97514
15 phenotypes from 2 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Pcsk4tm1b(KOMP)Wtsi/Pcsk4tm1b(KOMP)Wtsi
C57BL/6N-Pcsk4tm1b(KOMP)Wtsi/J 		increased circulating sodium level J:211773
increased heart weight J:211773
Pcsk4tm1Mbi/Pcsk4+
involves: 129P2/OlaHsd * C57BL/6J 		transmission ratio distortion J:41503
Pcsk4tm1Mbi/Pcsk4tm1Mbi
B6.129P2-Pcsk4tm1Mbi 		abnormal acrosome assembly J:233570
abnormal acrosome reaction J:107011
abnormal proacrosomal vesicle fusion J:233570
abnormal sperm capacitation J:107011
abnormal sperm head morphology J:233570
abnormal sperm physiology J:233570
impaired binding of sperm to zona pellucida J:107011
impaired fertilization J:107011
reduced male fertility J:107011
Pcsk4tm1Mbi/Pcsk4tm1Mbi
involves: 129P2/OlaHsd * C57BL/6J 		decreased hyperactivated sperm motility J:41503
decreased litter size J:41503
impaired fertilization J:41503
reduced female fertility J:41503
reduced male fertility J:41503
transmission ratio distortion J:41503
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory