Pcx Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pcx
pyruvate carboxylase
MGI:97520

26 phenotypes from 2 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Pcx^{tm1b(EUCOMM)Wtsi}/Pcx⁺ C57BL/6N-Pcx^{tm1b(EUCOMM)Wtsi}/H	decreased bone mineral content	J:211773
	decreased lean body mass	J:211773
	decreased respiratory quotient	J:211773
	increased total body fat amount	J:211773
Pcx^{tm1b(EUCOMM)Wtsi}/Pcx⁺ C57BL/6N-Pcx^{tm1b(EUCOMM)Wtsi}/Ieg	increased grip strength	J:211773
Pcx^{tm1b(EUCOMM)Wtsi}/Pcx^{tm1b(EUCOMM)Wtsi} C57BL/6N-Pcx^{tm1b(EUCOMM)Wtsi}/H	preweaning lethality, complete penetrance	J:211773
Pcx^{tm1b(EUCOMM)Wtsi}/Pcx^{tm1b(EUCOMM)Wtsi} C57BL/6N-Pcx^{tm1b(EUCOMM)Wtsi}/Ieg	preweaning lethality, complete penetrance	J:211773
Pcx^{tm1c(EUCOMM)Wtsi}/Pcx^{tm1c(EUCOMM)Wtsi} Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: C57BL/6 * C57BL/6N * DBA * SJL	abnormal amino acid metabolism	J:332296
	abnormal fatty acid oxidation	J:332296
	abnormal insulin clearance	J:332296
	abnormal insulin secretion	J:332296
	abnormal liver physiology	J:332296
	abnormal mitochondrial physiology	J:332296
	decreased circulating glucose level	J:332296
	decreased fasting circulating glucose level	J:332296
	normal growth/size/body region phenotype	J:332296
	hepatic steatosis	J:332296
	hypoglycemia	J:332296
	impaired gluconeogenesis	J:332296
	improved glucose tolerance	J:332296
	increased circulating free fatty acids level	J:332296
	increased circulating ketone body level	J:332296
	increased circulating lactate level	J:332296
	increased circulating triglyceride level	J:332296
	increased kidney weight	J:332296
	increased liver triglyceride level	J:332296
	increased susceptibility to weight loss	J:332296

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24