Pde6b Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pde6b
phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide
MGI:97525

42 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Cacnb2^tm1Rgg/Cacnb2^tm1Rgg Pde6b^rd1/Pde6b^rd1 Tg(Myh6-Cacnb2)1Rgg/0 involves: 129S7/SvEvBrd * C57BL/6J * FVB	abnormal cone electrophysiology	J:80080
	abnormal eye electrophysiology	J:80080
	abnormal eye physiology	J:80080
	decreased retina photoreceptor cell number	J:79923
	disorganized retina outer plexiform layer	J:80080
	retina photoreceptor degeneration	J:79923
	thin retina outer nuclear layer	J:79923
	thin retina outer plexiform layer	J:80080
Casp3^tm1Flv/Casp3^tm1Flv Pde6b^rd1/Pde6b^rd1 involves: 129S1/Sv * C3H/FeJ * C57BL/6J	abnormal apoptosis	J:88367
	abnormal eye development	J:88367
	decreased retina rod cell number	J:88367
	thick retina outer nuclear layer	J:88367
Cry1^tm1Asn/Cry1^tm1Asn Cry2^tm1Asn/Cry2^tm1Asn Pde6b^rd1/Pde6b^rd1 involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6	abnormal circadian behavior phase	J:66580
	abnormal locomotor circadian rhythm	J:66580
	abnormal retina morphology	J:66580
	abnormal retina outer nuclear layer morphology	J:66580
	absent photoreceptor outer segment	J:66580
	absent retina rod cells	J:66580
	decreased locomotor activity	J:66580
	decreased retina cone cell number	J:66580
	impaired pupillary reflex	J:81500
	retina degeneration	J:66580
Cry1^tm1Asn/Cry1^tm1Asn Pde6b^rd1/Pde6b^rd1 involves: 129P2/OlaHsd	impaired pupillary reflex	J:81500
Cry2^tm1Asn/Cry2^tm1Asn Pde6b^rd1/Pde6b^rd1 involves: 129P2/OlaHsd	impaired pupillary reflex	J:81500
Hps4^le/Hps4^le Pde6b^rd1/Pde6b^rd1 B6.C3-Pde6b^rd1 Hps4^le	abnormal retina inner nuclear layer morphology	J:5812
	decreased ear pigmentation	J:5812
	normal vision/eye phenotype	J:5812
Hps4^le/Hps4^le Pde6b^rd1/Pde6b^rd1 B6.C3-Pde6b^rd1 Hps4^le/J	abnormal platelet activation	J:221384
	decreased platelet aggregation	J:221384
Opn4^tm1Skay/Opn4^tm1Skay Pde6b^rd1/Pde6b^rd1 B6.Cg-Pde6b^rd1 Opn4^tm1Skay	abnormal eye physiology	J:227078
Opn4^tm1Skay/Opn4^tm1Skay Pde6b^rd1/Pde6b^rd1 involves: 129S1/SvImJ * C57BL/6	abnormal circardian behavior entrainment	J:137151
	impaired pupillary reflex	J:137151
Pde6a^nmf282/Pde6a⁺ Pde6b^rd1-2J/Pde6b⁺ involves: A/J * C57BL/6J	normal vision/eye phenotype	J:142108
Pde6a^nmf363/Pde6a⁺ Pde6b^rd1-2J/Pde6b⁺ C57BL/6J-Pde6b^rd1-2J Pde6a^nmf363	normal vision/eye phenotype	J:142108
Pde6b^rd1/Pde6b^rd1 Pde6g^tm1Goff/Pde6g^tm1Goff either: (involves: 129S/SvEv * C57BL/6 * MF1 * Swiss Webster) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * MF1 * Swiss Webster)	abnormal eye electrophysiology	J:33048
	abnormal retina photoreceptor layer morphology	J:33048
Pde6b^rd1/Pde6b^rd1 Prkcq^rpea1/Prkcq^rpea1 ABJ/LeJ-Prkcq^rpea1/Boc	abnormal ocular fundus morphology	J:237977
	buphthalmos	J:237977
	cataract	J:237977
	decreased retina ganglion cell number	J:237977
	decreased retina photoreceptor cell number	J:237977
	ocular hypertension	J:237977
Pde6b^rd1/Pde6b^rd1 Prkcq^rpea1/Prkcq^rpea1 B6.ABJ-Prkcq^rpea1 Pde6b^rd1/Boc	abnormal ocular fundus morphology	J:237977
	buphthalmos	J:237977
	cataract	J:237977
	decreased retina ganglion cell number	J:237977
	decreased retina photoreceptor cell number	J:237977
	ocular hypertension	J:237977
	retina detachment	J:237977
	serous retina detachment	J:237977
Pde6b^rd1/Pde6b^rd1 Prph2^Rd2/Prph2^Rd2 either: C.Cg-Pde6b^rd1 Prph2^Rd2 or C3.Cg-Pde6b^rd1 Prph2^Rd2	abnormal Muller cell morphology	J:27850
	absent photoreceptor outer segment	J:27850
	retina photoreceptor degeneration	J:27850
Pde6b^rd1/Pde6b^rd1 Prph2^Rd2/Prph2^Rd2 involves: C3Hf/HeA * C57BL/LiA * O20/A	retina outer nuclear layer degeneration	J:12044
Pde6b^rd1/Pde6b^rd1 Rho^{tm2(RHO/GFP)Jhw}/Rho⁺ either: (involves: 129S7/SvEvBrd * C57BL/6J * FVB) or (involves: 129S7/SvEvBrd * C57BL/6-Tyr^c * FVB)	retina degeneration	J:91038
Pde6b^rd1/Pde6b^rd1 Tg(OPN1LW-DT)1Mame/? involves: C3H/He * C57BL/6 * C57BL/6J	abnormal retina morphology	J:128149
	abnormal retina outer nuclear layer morphology	J:128478
	abnormal retina photoreceptor morphology	J:128478
	normal behavior/neurological phenotype	J:128149, J:128478
	retina degeneration	J:128149
	thin retina inner nuclear layer	J:128149
Pde6b^rd1/Pde6b^rd1 Tg(OPN1LW-DT)1Mame/? Not Specified	abnormal visual contrast sensitivity	J:199509

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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