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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Pdgfb
platelet derived growth factor, B polypeptide
MGI:97528
65 phenotypes from 3 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Pdgfbtm1Cbet/Pdgfbtm1Cbet
involves: 129P2/OlaHsd * C57BL/6 		abnormal aorta smooth muscle morphology J:20017
abnormal artery morphology J:20017
abnormal blood vessel morphology J:20017, J:78912
abnormal capillary morphology J:78912
abnormal coronary vessel morphology J:20017
abnormal glial cell morphology J:78912
abnormal heart right ventricle morphology J:20017
abnormal kidney morphology J:20017
abnormal pericyte morphology J:56682
abnormal placenta vasculature J:56682
abnormal placental labyrinth vasculature morphology J:56682
abnormal renal glomerulus morphology J:20017
abnormal trophoblast layer morphology J:56682
abnormal urinary bladder morphology J:20017
abnormal vascular endothelial cell morphology J:78912
absent mesangial cell J:20017
congestive heart failure J:20017
decreased hematocrit J:20017
decreased hemoglobin content J:20017
decreased mesangial cell number J:20017
dilated aorta J:20017
dilated heart left ventricle J:20017
dilated heart right ventricle J:20017
enlarged heart J:20017
erythroblastosis J:20017
hemorrhage J:20017
increased mean corpuscular volume J:20017
increased vascular endothelial cell number J:78912
kidney microaneurysm J:20017
lethality throughout fetal growth and development, incomplete penetrance J:20017
macrocytic anemia J:20017
perinatal lethality, incomplete penetrance J:20017
respiratory failure J:20017
skin edema J:20017
small kidney J:20017
small liver J:20017
thrombocytopenia J:20017
Pdgfbtm1Cbet/Pdgfbtm2Cbet
Tg(Tie1-cre)9Ref/0
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA 		abnormal capillary morphology J:89186
abnormal microglial cell morphology J:89186
abnormal pericyte morphology J:78544, J:89186
abnormal placenta vasculature J:89186
abnormal renal glomerulus morphology J:89186
abnormal retina morphology J:78544
abnormal retina neuronal layer morphology J:78544
abnormal retina vasculature morphology J:78544
albuminuria J:89186
brain aneurysm J:89186
decreased capillary density J:89186
decreased mesangial cell number J:89186
dilated glomerular capillary J:89186
gliosis J:89186
increased capillary tortuosity J:89186
intracerebral hemorrhage J:89186
thin myocardium J:89186
Pdgfbtm1Cbet/Pdgfbtm3.1Cbet
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ 		abnormal pericyte morphology J:84701
perinatal lethality, complete penetrance J:84701
Pdgfbtm3.1Cbet/Pdgfbtm3.1Cbet
involves: 129S1/Sv * 129X1/SvJ 		abnormal capillary morphology J:84701
abnormal eye morphology J:84701
abnormal glomerular mesangium morphology J:84701
abnormal pericyte morphology J:84701
abnormal retina morphology J:84701
abnormal retina neuronal layer morphology J:84701
abnormal retina photoreceptor layer morphology J:84701
abnormal retina pigment epithelium morphology J:84701
abnormal retina vasculature morphology J:84701
abnormal vascular smooth muscle morphology J:84701
albuminuria J:84701
decreased mesangial cell number J:84701
dilated glomerular capillary J:84701
expanded mesangial matrix J:84701
gliosis J:84701
glomerulosclerosis J:84701
increased urine protein level J:84701
microphthalmia J:84701
postnatal growth retardation J:84701
reduced female fertility J:84701
retina degeneration J:84701
retina fibrosis J:84701
Pdgfbtm3.1Cbet/Pdgfbtm3.1Cbet
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal astrocyte morphology J:166532
abnormal capillary morphology J:166532
abnormal pericyte morphology J:166532
decreased capillary density J:166532
impaired blood-brain barrier function J:166532
Pdgfbtm3.1Cbet/Pdgfbtm3.1Cbet
Tg(Fabp4-lacZ)4Mosh/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N 		abnormal blood vessel morphology J:166532
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory