Pdgfrb Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pdgfrb
platelet derived growth factor receptor, beta polypeptide
MGI:97531

92 phenotypes from 16 alleles in 16 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Pdgfrb^b2b2903Clo/Pdgfrb^b2b2903Clo C57BL/6J-Pdgfrb^b2b2903Clo	abnormal left subclavian artery morphology	J:175213
	abnormal pulmonary artery morphology	J:175213
	atrioventricular septal defect	J:175213
	clinodactyly	J:175213
	double outlet right ventricle	J:175213
	micrognathia	J:175213
	muscular ventricular septal defect	J:175213
	overriding aortic valve	J:175213
	perimembraneous ventricular septal defect	J:175213
	petechiae	J:175213
	right aortic arch	J:175213
	short snout	J:175213
	thymus hypoplasia	J:175213
	vascular ring	J:175213
	ventricular septal defect	J:175213
Pdgfrb^redeye/Pdgfrb^redeye C3N.C-Pdgfrb^redeye	abnormal basement membrane morphology	J:199483
	abnormal blood-retina barrier function	J:199483
	abnormal pericyte morphology	J:199483
	abnormal retina blood vessel morphology	J:199483
	abnormal retina blood vessel pattern	J:199483
	abnormal retina vasculature morphology	J:199483
	decreased retina ganglion cell number	J:199483
	eye hemorrhage	J:199483
	normal homeostasis/metabolism phenotype	J:199483
	increased retina apoptosis	J:199483
	increased vascular permeability	J:199483
	normal renal/urinary system phenotype	J:199483
	retina ganglion cell degeneration	J:199483
	normal vision/eye phenotype	J:199483
Pdgfrb^{tm1b(EUCOMM)Hmgu}/Pdgfrb⁺ C57BL/6N-Pdgfrb^{tm1b(EUCOMM)Hmgu}/H	abnormal seminal vesicle morphology	J:211773
	decreased circulating fructosamine level	J:211773
	enlarged heart	J:211773
	increased circulating triglyceride level	J:211773
Pdgfrb^{tm1b(EUCOMM)Hmgu}/Pdgfrb^{tm1b(EUCOMM)Hmgu} C57BL/6N-Pdgfrb^{tm1b(EUCOMM)Hmgu}/H	preweaning lethality, complete penetrance	J:211773
Pdgfrb^tm1Mdt/Pdgfrb^tm1Mdt H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ involves: C57BL/6 * CBA	perimembraneous ventricular septal defect	J:122584
Pdgfrb^tm1Msas/Pdgfrb^tm1Msas involves: 129 * C57BL/6	decreased cell proliferation	J:110798
	impaired wound healing	J:110798
	increased apoptosis	J:110798
Pdgfrb^tm1Msas/Pdgfrb^tm1Msas Tg(Nes-cre)1Nogu/0 B6J.Cg-Pdgfrb^tm1Msas Tg(Nes-cre)1Nogu	abnormal nervous system electrophysiology	J:229179
	abnormal social investigation	J:229179
	decreased neuron number	J:229179
	decreased prepulse inhibition	J:229179
	reduced sensorimotor gating	J:229179
Pdgfrb^tm1Msas/Pdgfrb^tm1Msas Tg(Nes-cre)1Nogu/? involves: 129 * C57BL/6	abnormal response to injury	J:110616
	increased susceptibility to neuronal excitotoxicity	J:110616
Pdgfrb^tm1Rheu/Pdgfrb^tm1Rheu involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal embryonic hematopoiesis	J:138069
	abnormal fibroblast migration	J:93973
	decreased fibroblast apoptosis	J:93973
Pdgfrb^tm1Sor/Pdgfrb^tm1Sor either: 129S7/SvEvBrd-Pdgfrb^tm1Sor or (involves: 129S7/SvEvBrd * C57BL/6J)	abnormal erythrocyte morphology	J:20016
	abnormal venule morphology	J:20016
	absent mesangial cell	J:20016
	absent podocytes	J:20016
	anemia	J:20016
	anisocytosis	J:20016
	decreased glomerular capillary number	J:20016
	glomerulus hemorrhage	J:20016
	hemorrhage	J:20016
	hydrops fetalis	J:20016
	increased nucleated erythrocyte cell number	J:20016
	kidney hemorrhage	J:20016
	lethality throughout fetal growth and development, incomplete penetrance	J:20016
	pallor	J:20016
	perinatal lethality, incomplete penetrance	J:20016
	poikilocytosis	J:20016
	polychromatophilia	J:20016
	purpura	J:20016
	schistocytosis	J:20016
	thrombocytopenia	J:20016
Pdgfrb^tm1Sor/Pdgfrb^tm1Sor involves: 129S7/SvEvBrd	abnormal angiogenesis	J:138069
Pdgfrb^tm1Sor/Pdgfrb^tm1Sor involves: 129S7/SvEvBrd	decreased angiogenesis	J:138069
Pdgfrb^tm1Sor/Pdgfrb^tm1Sor involves: 129S7/SvEvBrd * C57BL/6	abnormal blood vessel morphology	J:78912
	abnormal pericyte morphology	J:56682
	abnormal placenta vasculature	J:56682
	abnormal placental labyrinth vasculature morphology	J:56682
	abnormal trophoblast layer morphology	J:56682
	abnormal vascular endothelial cell morphology	J:78912
	increased vascular endothelial cell number	J:78912
Pdgfrb^tm1Sor/Pdgfrb^tm8Sor involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6	abnormal blood vessel morphology	J:86542
	abnormal eye morphology	J:86542
	abnormal heart morphology	J:86542
	abnormal pericyte morphology	J:86542
	abnormal retina vasculature morphology	J:86542
	cardiac fibrosis	J:86542
	dilated heart atrium	J:86542
	eye hemorrhage	J:86542
	eye opacity	J:86542
	increased heart ventricle size	J:86542
Pdgfrb^tm1Sor/Pdgfrb^tm9Sor involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6	abnormal blood vessel morphology	J:86542
	abnormal eye morphology	J:86542
	abnormal heart morphology	J:86542
	abnormal pericyte morphology	J:86542
	abnormal retina vasculature morphology	J:86542
	cardiac fibrosis	J:86542
	dilated heart atrium	J:86542
	eye hemorrhage	J:86542
	eye opacity	J:86542
	increased heart ventricle size	J:86542
Pdgfrb^tm2Msas/Pdgfrb^tm2Msas Tg(Nes-cre)1Nogu/? involves: 129 * C57BL/6	abnormal response to injury	J:110616
Pdgfrb^tm2Sor/Pdgfrb^tm2Sor either: 129S7/SvEvBrd-Pdgfrb^tm2Sor or (involves: 129S7/SvEvBrd * C57BL/6J)	abnormal erythrocyte morphology	J:20016
	abnormal venule morphology	J:20016
	absent mesangial cell	J:20016
	absent podocytes	J:20016
	anemia	J:20016
	anisocytosis	J:20016
	decreased glomerular capillary number	J:20016
	glomerulus hemorrhage	J:20016
	hemorrhage	J:20016
	hydrops fetalis	J:20016
	increased nucleated erythrocyte cell number	J:20016
	kidney hemorrhage	J:20016
	lethality throughout fetal growth and development, incomplete penetrance	J:20016
	pallor	J:20016
	perinatal lethality, incomplete penetrance	J:20016
	poikilocytosis	J:20016
	polychromatophilia	J:20016
	purpura	J:20016
	schistocytosis	J:20016
	thrombocytopenia	J:20016
Pdgfrb^tm7Sor/Pdgfrb^tm7Sor involves: 129S4/SvJae * C57BL/6	abnormal blood vessel morphology	J:86542
Pdgfrb^tm7Sor/Pdgfrb^tm7Sor involves: 129S4/SvJae * C57BL/6	abnormal pericyte morphology	J:86542
Pdgfrb^tm8Sor/Pdgfrb^tm8Sor involves: 129S4/SvJae * C57BL/6	abnormal blood vessel morphology	J:86542
	abnormal kidney vasculature morphology	J:86542
	abnormal pericyte morphology	J:86542
	abnormal renal glomerulus morphology	J:86542
Pdgfrb^tm9Sor/Pdgfrb^tm9Sor involves: 129S4/SvJae * C57BL/6	abnormal blood vessel morphology	J:86542
	abnormal kidney vasculature morphology	J:86542
	abnormal pericyte morphology	J:86542
	abnormal retina layer morphology	J:86542
	abnormal retina vasculature morphology	J:86542
Pdgfrb^tm10Sor/Pdgfrb^tm10Sor involves: 129S4/SvJae * C57BL/6	hemorrhage	J:86542
	hydrops fetalis	J:86542
	intracranial hemorrhage	J:86542
	kidney hemorrhage	J:86542
	perinatal lethality	J:86542
	skin hemorrhage	J:86542
Pdgfrb^tm11Sor/Pdgfrb^tm11Sor Tg(Nr5a1-cre)2Klp/0 either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)	normal reproductive system phenotype	J:142042
Pdgfrb^{tm12(Pdgfrb)Sor}/Pdgfrb⁺ Meox2^tm1(cre)Sor/Meox2⁺ involves: 129S4/SvJaeSor * C57BL/6	no abnormal phenotype detected	J:173602
Pdgfrb^{tm12(Pdgfrb)Sor}/Pdgfrb⁺ Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ involves: 129S4/SvJae * C57BL/6 * CBA	no abnormal phenotype detected	J:173602
Pdgfrb^{tm13(Pdgfrb)Sor}/Pdgfrb⁺ Meox2^tm1(cre)Sor/Meox2⁺ involves: 129S4/SvJaeSor * C57BL/6	postnatal growth retardation	J:173602
	postnatal lethality, complete penetrance	J:173602
Pdgfrb^{tm13(Pdgfrb)Sor}/Pdgfrb⁺ Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ involves: 129S4/SvJae * C57BL/6 * CBA	increased aorta wall thickness	J:173602
	postnatal growth retardation	J:173602
	postnatal lethality, complete penetrance	J:173602

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