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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Pdha1
pyruvate dehydrogenase E1 alpha 1
MGI:97532
34 phenotypes from 2 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Pdha1tm1.1Ptl/Y
involves: 129P2/OlaHsd * FVB/N 		decreased embryo size J:74192
embryonic growth retardation J:74192
embryonic lethality, complete penetrance J:74192
Pdha1tm1.1Ptl/Pdha1tm1.1Ptl
involves: 129P2/OlaHsd * FVB/N 		decreased embryo size J:74192
embryonic growth retardation J:74192
embryonic lethality, complete penetrance J:74192
Pdha1tm1Ptl/Pdha1+
Tg(Ckmm-cre)5Khn/0
involves: 129P2/OlaHsd * FVB 		abnormal heart left ventricle morphology J:141289
decreased cardiac muscle contractility J:141289
increased body weight J:141289
increased circulating insulin level J:141289
increased heart weight J:141289
increased myocardial fiber size J:141289
Pdha1tm1Ptl/Pdha1tm1Ptl
Tg(Nes-cre)1Kln/0
involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL 		abnormal brain white matter morphology J:94805
abnormal cerebellar granule layer morphology J:94805
abnormal cerebellar molecular layer J:94805
abnormal cerebellar peduncle morphology J:94805
abnormal cerebellum deep nucleus morphology J:94805
abnormal cerebral cortex pyramidal cell morphology J:94805
abnormal neocortex morphology J:94805
abnormal olfactory tract morphology J:94805
abnormal paraventricular thalamic nucleus morphology J:94805
abnormal putamen morphology J:94805
abnormal thalamus morphology J:94805
decreased brain weight J:94805
decreased corpus callosum size J:94805
decreased Purkinje cell number J:94805
decreased stria medullaris size J:94805
prenatal lethality, incomplete penetrance J:94805
small cerebellum J:94805
Pdha1tm1Ptl/Pdha1tm1Ptl
Tg(Zp3-cre)93Knw/0
involves: 129P2/OlaHsd * C57BL/6J 		abnormal female meiosis J:123893
abnormal oocyte morphology J:123893
abnormal polar body morphology J:123893
female infertility J:123893
impaired spindle assembly in female meiosis J:123893
Pdha1tm1Ptl/Y
Tg(Ckmm-cre)5Khn/0
involves: 129P2/OlaHsd * FVB 		abnormal heart left ventricle morphology J:141289
decreased cardiac muscle contractility J:141289
heart left ventricle hypertrophy J:141289
increased body weight J:141289
increased circulating insulin level J:141289
increased heart weight J:141289
increased myocardial fiber size J:141289
premature death J:141289
Pdha1tm1Ptl/Y
Tg(Nes-cre)1Kln/0
involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL 		prenatal lethality, complete penetrance J:94805
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory