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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Prf1
perforin 1 (pore forming protein)
MGI:97551
87 phenotypes from 6 alleles in 14 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Prf1m1Btlr/Prf1m1Btlr
C57BL/6J-Prf1m1Btlr 		increased susceptibility to Herpesvirales infection J:216044
increased susceptibility to Herpesvirales infection induced morbidity/mortality J:216044
Prf1tm1.1(KOMP)Vlcg/Prf1tm1.1(KOMP)Vlcg
C57BL/6N-Prf1tm1.1(KOMP)Vlcg/Ucd 		decreased mean corpuscular hemoglobin concentration J:211773
Prf1tm1Clrk/Prf1tm1Clrk
C.129S7(B6)-Prf1tm1Clrk 		abnormal cytokine secretion J:71576
normal immune system phenotype J:71576
increased activated T cell number J:71576
increased interferon-gamma secretion J:71576
increased susceptibility to Riboviria infection J:71576
increased tumor necrosis factor secretion J:71576
Prf1tm1Clrk/Prf1tm1Clrk
involves: 129S7/SvEvBrd * BALB/c * NOD 		decreased susceptibility to autoimmune diabetes J:64051
Prf1tm1Clrk/Prf1tm1Clrk
involves: 129S7/SvEvBrd * C57BL/6 		decreased cytotoxic T cell cytolysis J:21531
normal immune system phenotype J:21531
increased susceptibility to Riboviria infection J:21531
Prf1tm1Geno/Prf1tm1Geno
involves: C57BL/6 		no abnormal phenotype detected J:142654
Prf1tm1Sdz/Prf1+
A.B6-Prf1tm1Sdz 		impaired natural killer cell mediated cytotoxicity J:211842
increased incidence of induced tumors J:211842
Prf1tm1Sdz/Prf1+
NOD.B6-Prf1tm1Sdz 		decreased susceptibility to autoimmune diabetes J:43468
insulitis J:43468
periinsulitis J:43468
Prf1tm1Sdz/Prf1tm1Sdz
A.B6-Prf1tm1Sdz 		impaired natural killer cell mediated cytotoxicity J:211842
increased incidence of induced tumors J:211842
Prf1tm1Sdz/Prf1tm1Sdz
C57BL/6-Prf1tm1Sdz 		abnormal female reproductive system physiology J:59892
abnormal inflammatory response J:17986
abnormal leukocyte physiology J:17986
abnormal NK cell physiology J:113213
decreased cytotoxic T cell cytolysis J:17986
decreased tumor latency J:77491
impaired natural killer cell mediated cytotoxicity J:17986
increased B cell derived lymphoma incidence J:77491
increased interleukin-10 secretion J:123934
increased lymphoma incidence J:77491
increased susceptibility to bacterial infection J:123934
increased susceptibility to induced morbidity/mortality J:113213
increased susceptibility to infection J:17986
increased susceptibility to parasitic infection J:81397
increased susceptibility to Riboviria infection J:17986
premature death J:77491
Prf1tm1Sdz/Prf1tm1Sdz
C57BL/6-Prf1tm1Sdz/J 		abnormal behavior J:120427
abnormal body temperature homeostasis J:92260
abnormal brain meninges morphology J:92260
abnormal circulating cytokine level J:92260
abnormal cytotoxic T cell physiology J:193137
abnormal lymph node morphology J:92260
abnormal lymphocyte physiology J:120427
abnormal macrophage activation involved in immune response J:92260
abnormal spleen white pulp morphology J:92260
abnormal T cell activation J:92260
normal behavior/neurological phenotype J:120427
brain inflammation J:92260, J:120427
CNS inflammation J:120427
decreased body temperature J:193137
decreased bone marrow cell number J:92260
decreased circulating fibrinogen level J:92260
decreased cytotoxic T cell cytolysis J:193137
decreased erythrocyte cell number J:193137
decreased interferon-gamma secretion J:92260
decreased leukocyte cell number J:193137
decreased locomotor activity J:92260
decreased neutrophil cell number J:193137
decreased NK cell degranulation J:193137
demyelination J:120427
hunched posture J:92260, J:193137
normal immune system phenotype J:120427
increased circulating aspartate transaminase level J:193137
increased circulating interferon-alpha level J:92260
increased circulating interferon-gamma level J:92260, J:193137
increased circulating interleukin-1 beta level J:193137
increased circulating interleukin-6 level J:92260, J:193137
increased circulating interleukin-10 level J:92260
increased circulating interleukin-18 level J:92260
increased circulating lactate dehydrogenase level J:193137
increased circulating triglyceride level J:92260
increased circulating tumor necrosis factor level J:92260, J:193137
increased spleen red pulp amount J:92260
increased susceptibility to Picornaviridae infection J:120427
increased susceptibility to Riboviria infection J:92260, J:193137
increased susceptibility to Riboviria infection induced morbidity/mortality J:92260
increased susceptibility to viral infection induced morbidity/mortality J:193137
lethargy J:193137
liver inflammation J:92260
lymph node inflammation J:92260
lymph node necrosis J:92260
pancytopenia J:92260, J:193137
ruffled hair J:92260
thrombocytopenia J:193137
weight loss J:193137
Prf1tm1Sdz/Prf1tm1Sdz
C.B6-Prf1tm1Sdz 		abnormal tumor morphology J:77491
increased lung adenocarcinoma incidence J:77491
increased lymphoma incidence J:77491
increased sarcoma incidence J:77491
increased T cell derived lymphoma incidence J:77491
increased tumor latency J:77491
Prf1tm1Sdz/Prf1tm1Sdz
involves: BALB/c * C57BL/6 		impaired natural killer cell mediated cytotoxicity J:73948
Prf1tm1Sdz/Prf1tm1Sdz
NOD.B6-Prf1tm1Sdz 		abnormal circulating glucose level J:43468
decreased pancreatic beta cell number J:43468
decreased susceptibility to autoimmune diabetes J:43468
increased physiological sensitivity to xenobiotic J:43468
insulitis J:43468
periinsulitis J:43468
Prf1tm1Tsc/Prf1+
involves: 129S2/SvPas 		decreased cytotoxic T cell cytolysis J:21731
impaired natural killer cell mediated cytotoxicity J:21731
Prf1tm1Tsc/Prf1tm1Tsc
129X1.129S2-Prf1tm1Tsc 		abnormal NK cell physiology J:126114
decreased T cell apoptosis J:126114
increased susceptibility to induced morbidity/mortality J:126114
increased tumor growth/size J:126114
Prf1tm1Tsc/Prf1tm1Tsc
involves: 129S2/SvPas 		decreased circulating alanine transaminase level J:50903
decreased cytotoxic T cell cytolysis J:21731
decreased susceptibility to bacterial infection J:50903
impaired natural killer cell mediated cytotoxicity J:21731
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/05/2024
MGI 6.24 		The Jackson Laboratory