Pgd Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pgd
phosphogluconate dehydrogenase
MGI:97553

30 phenotypes from 2 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Pgd^tm1.1Pse/Pgd^tm1.1Pse Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	abnormal CD4-positive helper T cell morphology	J:313817
	abnormal regulatory T cell physiology	J:313817
	blepharitis	J:313817
	decreased body size	J:313817
	ear inflammation	J:313817
	enlarged lymph nodes	J:313817
	enlarged spleen	J:313817
	increased circulating interferon-gamma level	J:313817
	increased circulating interleukin-4 level	J:313817
	increased circulating interleukin-5 level	J:313817
	increased circulating interleukin-17 level	J:313817
	increased IgA level	J:313817
	increased IgD level	J:313817
	increased IgE level	J:313817
	increased IgG2a level	J:313817
	increased IgG3 level	J:313817
	increased IgM level	J:313817
	increased interferon-gamma secretion	J:313817
	increased susceptibility to type I hypersensitivity reaction	J:313817
	increased T cell number	J:313817
	premature death	J:313817
Pgd^tm1.1Pse/Pgd^tm1.1Pse Foxp3^{tm9(EGFP/cre/ERT2)Ayr}/Foxp3⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	decreased tumor growth/size	J:313817
Pgd^tm1.1Pse/Pgd^tm1.1Pse Tg(Cd4-cre)1Cwi/0 involves: C57BL/6 * DBA/2	abnormal alpha-beta T cell morphology	J:306553
	abnormal CD8-positive, alpha beta T cell morphology	J:306553
	abnormal CD8-positive, alpha-beta T cell physiology	J:306553
	abnormal T cell differentiation	J:306553
	decreased CD4-positive, alpha-beta T cell number	J:306553
	decreased CD8-positive, alpha-beta T cell number	J:306553
	increased glycogen level	J:306553
Pgd^{tm1a(EUCOMM)Wtsi}/Pgd⁺ C57BL/6N-Pgd^{tm1a(EUCOMM)Wtsi}/Ics	abnormal bone mineralization	J:165965

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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