Abcb1a Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Abcb1a
ATP-binding cassette, sub-family B member 1A
MGI:97570

32 phenotypes from 2 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Abcb1a^mds/Abcb1a^mds involves: CF-1	abnormal hippocampus CA3 region morphology	J:64725
	catalepsy	J:64725
	hippocampal neuron degeneration	J:64725
	increased eosinophil cell number	J:64725
	increased physiological sensitivity to xenobiotic	J:40292, J:64725
	premature death	J:64725
	tremors	J:64725
Abcb1a^tm1Bor/Abcb1a^tm1Bor FVB.129P2-Abcb1a^tm1Bor/TacImx	abnormal intestinal epithelium morphology	J:51190
	abnormal intestinal mucosa morphology	J:51190
	abnormal large intestine crypts of Lieberkuhn morphology	J:51190
	abnormal lymphocyte physiology	J:51190
	cachexia	J:51190
	colitis	J:51190
	crypts of Lieberkuhn abscesses	J:51190
	increased IgA level	J:51190
	increased IgE level	J:51190
	increased IgG1 level	J:51190
	increased IgG2 level	J:51190
	increased IgG2a level	J:51190
	increased IgG2b level	J:51190
	increased IgG3 level	J:51190
	increased IgM level	J:51190
	increased immunoglobulin level	J:51190
	intestinal ulcer	J:51190
	large intestinal inflammation	J:51190
	mucous diarrhea	J:51190
Abcb1a^tm1Bor/Abcb1a^tm1Bor FVBTac.129P2-Abcb1a^tm1Bor	abnormal blood-inner ear barrier function	J:59145
	abnormal CD8 positive, alpha-beta intraepithelial T cell morphology	J:102640
	abnormal xenobiotic pharmacokinetics	J:59145, J:102640
	decreased gamma-delta intraepithelial T cell number	J:102640
	increased physiological sensitivity to xenobiotic	J:59145
	increased susceptibility to ototoxicity-induced hearing loss	J:59145
Abcb1a^tm1Bor/Abcb1a^tm1Bor involves: 129P2/OlaHsd * FVB	abnormal xenobiotic pharmacokinetics	J:39804
	impaired blood-brain barrier function	J:18554
	increased physiological sensitivity to xenobiotic	J:18554

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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