About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Pik3r1
phosphoinositide-3-kinase regulatory subunit 1
MGI:97583
64 phenotypes from 9 alleles in 12 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Pik3r1m1Btlr/Pik3r1m1Btlr
C57BL/6J-Pik3r1m1Btlr 		decreased B cell number J:254890
decreased B-1a cell number J:254890
increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number J:254890
increased CD8-positive, alpha-beta memory T cell number J:254890
Pik3r1M2Btlr/Pik3r1+
C57BL/6J-Pik3r1M2Btlr 		decreased B-1 B cell number J:254892
decreased B-1a cell number J:254892
decreased B-1b cell number J:254892
decreased B-2 B cell number J:254892
decreased NK T cell number J:254892
increased B-1b cell number J:254892
Pik3r1m3Btlr/Pik3r1m3Btlr
C57BL/6J-Pik3r1m3Btlr 		increased B-1b cell number J:272853
Pik3r1tm1.1Geno/Pik3r1+
involves: C57BL/6 * C57BL/6J 		abnormal epididymal fat pad morphology J:234657
decreased adipocyte glucose uptake J:234657
decreased body length J:234657
decreased body size J:234657
decreased body weight J:234657
decreased insulin secretion J:234657
decreased subcutaneous adipose tissue amount J:234657
decreased white fat cell size J:234657
hyperglycemia J:234657
impaired glucose tolerance J:234657
increased circulating insulin level J:234657
increased circulating insulin-like growth factor I level J:234657
insulin resistance J:234657
lipodystrophy J:234657
pancreatic islet hyperplasia J:234657
Pik3r1tm1.1Geno/Pik3r1tm1.1Geno
involves: C57BL/6 * C57BL/6J 		embryonic lethality, complete penetrance J:234657
Pik3r1tm1Dfr/Pik3r1tm1Dfr
involves: 129S6/SvEvTac 		abnormal B cell differentiation J:104166
decreased immature B cell number J:104166
decreased mature B cell number J:104166
decreased pre-B cell number J:104166
increased pro-B cell number J:104166
Pik3r1tm1Dfr/Pik3r1tm1Dfr
involves: 129S6/SvEvTac * C57BL/6 		abnormal brown adipose tissue morphology J:65523
abnormal glucose homeostasis J:65523
arrested B cell differentiation J:52229
chylous ascites J:65523
decreased B cell proliferation J:52229
decreased circulating insulin level J:65523
decreased mature B cell number J:52229
dystrophic cardiac calcinosis J:65523
hepatic necrosis J:65523
hypoglycemia J:65523
improved glucose tolerance J:65523
increased skeletal muscle fiber size J:65523
postnatal lethality, incomplete penetrance J:52229
Pik3r1tm1Khn/Pik3r1tm1Khn
involves: 129S4/SvJae * C57BL/6J 		abnormal fat cell morphology J:87598
abnormal fat pad morphology J:87598
abnormal glucose homeostasis J:87598
abnormal lipid homeostasis J:87598
decreased circulating insulin level J:87598
decreased triglyceride level J:87598
normal growth/size/body region phenotype J:87598
increased insulin sensitivity J:87598
Pik3r1tm1Lca/Pik3r1tm1Lca
Tg(Ckmm-cre)5Khn/0
involves: 129S6/SvEvTac * C57BL/6 * FVB 		no abnormal phenotype detected J:102176
Pik3r1tm1Lca/Pik3r1tm1Lca
Tg(OPN1LW-cre)4Yzl/0
involves: 129S6/SvEvTac * FVB/N 		abnormal retina cone cell morphology J:232389
abnormal ribbon synapse morphology J:232389
abnormal synapse morphology J:232389
decreased b-wave amplitude J:232389
retina cone cell degeneration J:232389
Pik3r1tm1Tka/Pik3r1tm1Tka
involves: C57BL/6 * CBA 		abnormal B cell physiology J:113491
abnormal humoral immune response J:52228
decreased B cell number J:52228
decreased B cell proliferation J:52228, J:113491
decreased circulating glucose level J:52576
decreased circulating insulin level J:52576
decreased mature B cell number J:52228
decreased pre-B cell number J:52228
decreased pro-B cell number J:52228
hypoglycemia J:52576
increased adipocyte glucose uptake J:52576
increased insulin sensitivity J:52576
increased skeletal muscle cell glucose uptake J:52576
increased susceptibility to bacterial infection J:52228
premature death J:52228
Pik3r1tm2Dfr/Pik3r1+
involves: 129S6/SvEvTac * BALB/c * C57BL/6 		hypoglycemia J:94077
improved glucose tolerance J:94077
increased insulin sensitivity J:94077
Pik3r1tm2Dfr/Pik3r1tm2Dfr
either: C.129S6-Pik3r1tm2Dfr or (involves: 129S6/SvEvTac * BALB/c * C57BL/6) 		abnormal B cell differentiation J:94077
abnormal erythropoiesis J:94077
chylous ascites J:94077
hepatic necrosis J:94077
hypoglycemia J:94077
increased skeletal muscle fiber size J:94077
perinatal lethality, complete penetrance J:94077
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory