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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Prkaca
protein kinase, cAMP dependent, catalytic, alpha
MGI:97592
27 phenotypes from 4 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Prkacatm1Gsm/Prkaca+
involves: 129X1/SvJ * C57BL/6 		abnormal skeleton development J:160299
decreased trabecular bone thickness J:160299
Prkacatm1Gsm/Prkacatm1Gsm
involves: 129X1/SvJ * C57BL/6 		asthenozoospermia J:77110
decreased body weight J:77110
decreased urine protein level J:77110
male infertility J:76765
postnatal growth retardation J:76765, J:77110
postnatal lethality, incomplete penetrance J:77110
normal reproductive system phenotype J:77110
Prkacatm2Gsm/Prkacatm2Gsm
involves: 129X1/SvJ * C57BL/6 		asthenozoospermia J:92616
impaired fertilization J:92616
male infertility J:92616
Prkacatm3Gsm/Prkacatm3Gsm
involves: 129X1/SvJ * C57BL/6J 		postnatal growth retardation J:103418
Prkacatm3Gsm/Prkacatm3Gsm
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129X1/SvJ * C57BL/6J 		abnormal glucose homeostasis J:103418
abnormal glycogen homeostasis J:103418
normal adipose tissue phenotype J:103418
decreased body length J:103418
decreased body size J:103418
decreased circulating insulin level J:103418
decreased insulin secretion J:103418
decreased liver glycogen level J:103418
impaired glucose tolerance J:103418
increased circulating glucose level J:103418
increased circulating triglyceride level J:103418
Tg(Camk2a-Prkaca)426Tabe/0
involves: C57BL/6J * CBA/J 		abnormal contextual conditioning behavior J:38837, J:110284
abnormal enzyme/coenzyme activity J:38837
abnormal spatial learning J:38837
decreased alcohol consumption J:70175
impaired righting response J:70175
reduced long-term potentiation J:38837
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory