Prkcd Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Prkcd
protein kinase C, delta
MGI:97598

45 phenotypes from 7 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Prkcd^M1Btlr/Prkcd^M1Btlr C57BL/6J-Prkcd^M1Btlr	increased susceptibility to induced colitis	J:265145
Prkcd^m2Btlr/Prkcd^m2Btlr C57BL/6J-Prkcd^m2Btlr	enhanced humoral immune response	J:265146
	increased IgM level	J:265146
	increased NK cell number	J:265146
	increased susceptibility to induced colitis	J:265146
Prkcd^tm1.1Chou/Prkcd^tm1.1Chou involves: C57BL/6 * C57BL/6NTac	abnormal neutrophil physiology	J:217880
Prkcd^tm1.1Khn/Prkcd^tm1.1Khn B6.129P2-Prkcd^tm1.1Khn	improved glucose tolerance	J:173902
Prkcd^tm1.1Khn/Prkcd^tm1.1Khn B6.129P2-Prkcd^tm1.1Khn	increased insulin sensitivity	J:173902
Prkcd^tm1Kin/Prkcd^tm1Kin involves: 129P2/OlaHsd	abnormal bone ossification	J:117333
	abnormal osteoblast differentiation	J:117333
	decreased width of hypertrophic chondrocyte zone	J:117333
Prkcd^tm1Kin/Prkcd^tm1Kin involves: 129P2/OlaHsd * C57BL/6	abnormal immunoglobulin level	J:143854
	abnormal lymph node germinal center morphology	J:76135
	abnormal pancreatic beta cell morphology	J:120293
	abnormal Peyer's patch germinal center morphology	J:76135
	abnormal plasma cell differentiation	J:143854
	decreased body weight	J:120293
	decreased insulin secretion	J:120293
	enlarged lymph nodes	J:76135
	enlarged spleen	J:76135
	glomerulonephritis	J:76135
	impaired glucose tolerance	J:120293
	increased acute inflammation	J:76135
	increased anti-chromatin antibody level	J:76135
	increased B cell number	J:76135
	increased B cell proliferation	J:76135, J:143854
	increased follicular B cell number	J:143854
	increased IgA level	J:76135, J:143854
	increased IgG1 level	J:76135, J:143854
	increased IgM level	J:143854
	increased interleukin-6 secretion	J:76135
	increased marginal zone B cell number	J:143854
	increased spleen germinal center number	J:76135
	increased transitional stage B cell number	J:143854
	renal glomerular immunoglobulin deposits	J:76135
Prkcd^tm1Msg/Prkcd^tm1Msg involves: 129X1/SvJ * C57BL/6J	abnormal neutrophil physiology	J:91377
	abnormal response to CNS ischemic injury	J:91377
	decreased neutrophil cell number	J:91377
Prkcd^tm1Qxu/Prkcd^tm1Qxu B6.129P2-Prkcd^tm1Qxu	decreased body weight	J:173902
	decreased liver triglyceride level	J:173902
	improved glucose tolerance	J:173902
	increased insulin sensitivity	J:173902
	premature death	J:173902
Prkcd^tm1Qxu/Prkcd^tm1Qxu involves: 129P2/OlaHsd	abnormal cardiovascular system physiology	J:78680
	abnormal response to transplant	J:78680
	arteriosclerosis	J:78680
	vascular smooth muscle hyperplasia	J:78680
Prkcd^tm1Qxu/Prkcd^tm1Qxu involves: 129P2/OlaHsd * C57BL/6	enlarged lymph nodes	J:76134
	enlarged spleen	J:76134
	normal immune system phenotype	J:76134
	increased anti-nuclear antigen antibody level	J:76134
	increased B cell apoptosis	J:76134
	increased B cell number	J:76134
	increased erythrocyte cell number	J:76134
	increased IgA level	J:76134
	increased IgG1 level	J:76134
	increased IgM level	J:76134
	premature death	J:76134

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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