Prkch Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Prkch
protein kinase C, eta
MGI:97600

33 phenotypes from 3 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Prkch^tm1.2Gasc/Prkch^tm1.2Gasc involves: C57BL/6 * FVB/N * SJL	abnormal brachial lymph node morphology	J:186080
	abnormal cervical lymph node morphology	J:186080
	abnormal effector T cell morphology	J:186080
	abnormal lymph node morphology	J:186080
	decreased B cell number	J:186080
	decreased CD4-positive, alpha-beta T cell number	J:186080
	decreased CD8-positive, alpha-beta T cell number	J:186080
	decreased DN1 thymic pro-T cell number	J:186080
	decreased DN4 thymocyte number	J:186080
	decreased double-positive T cell number	J:186080
	decreased lymphocyte cell number	J:186080
	decreased T cell number	J:186080
	decreased T cell proliferation	J:186080
	enlarged axillary lymph nodes	J:186080
	enlarged cervical lymph nodes	J:186080
	enlarged inguinal lymph nodes	J:186080
	enlarged lymph nodes	J:186080
	increased B cell number	J:186080
	increased CD4-positive, alpha-beta T cell number	J:186080
	increased CD8-positive, alpha-beta T cell number	J:186080
	increased memory T cell number	J:186080
	increased T cell number	J:186080
	thymus hypoplasia	J:186080
Prkch^{tm1b(EUCOMM)Hmgu}/Prkch^{tm1b(EUCOMM)Hmgu} B6N(Cg)-Prkch^{tm1b(EUCOMM)Hmgu}/J	decreased grip strength	J:211773
	increased lean body mass	J:211773
Prkch^tm1Cda/Prkch^tm1Cda B6.129S-Prkch^tm1Cda	delayed wound healing	J:83498
Prkch^tm1Cda/Prkch^tm1Cda B6.129S-Prkch^tm1Cda	impaired wound healing	J:83498
Prkch^tm1Cda/Prkch^tm1Cda involves: 129S/SvEv * C57BL/6J	abnormal eyelid aperture	J:83498
	decreased body weight	J:83498
	epidermal hyperplasia	J:83498
	increased incidence of tumors by chemical induction	J:83498
	increased skin papilloma incidence	J:83498
	postnatal lethality, incomplete penetrance	J:83498

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24