Prkch Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Prkch
protein kinase C, eta
MGI:97600

33 phenotypes from 3 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Prkch^tm1.2Gasc/Prkch^tm1.2Gasc involves: C57BL/6 * FVB/N * SJL	abnormal brachial lymph node morphology	J:186080
	abnormal cervical lymph node morphology	J:186080
	abnormal effector T cell morphology	J:186080
	abnormal lymph node morphology	J:186080
	decreased B cell number	J:186080
	decreased CD4-positive, alpha-beta T cell number	J:186080
	decreased CD8-positive, alpha-beta T cell number	J:186080
	decreased DN1 thymic pro-T cell number	J:186080
	decreased DN4 thymocyte number	J:186080
	decreased double-positive T cell number	J:186080
	decreased lymphocyte cell number	J:186080
	decreased T cell number	J:186080
	decreased T cell proliferation	J:186080
	enlarged axillary lymph nodes	J:186080
	enlarged cervical lymph nodes	J:186080
	enlarged inguinal lymph nodes	J:186080
	enlarged lymph nodes	J:186080
	increased B cell number	J:186080
	increased CD4-positive, alpha-beta T cell number	J:186080
	increased CD8-positive, alpha-beta T cell number	J:186080
	increased memory T cell number	J:186080
	increased T cell number	J:186080
	thymus hypoplasia	J:186080
Prkch^{tm1b(EUCOMM)Hmgu}/Prkch^{tm1b(EUCOMM)Hmgu} B6N(Cg)-Prkch^{tm1b(EUCOMM)Hmgu}/J	decreased grip strength	J:211773
	increased lean body mass	J:211773
Prkch^tm1Cda/Prkch^tm1Cda B6.129S-Prkch^tm1Cda	delayed wound healing	J:83498
Prkch^tm1Cda/Prkch^tm1Cda B6.129S-Prkch^tm1Cda	impaired wound healing	J:83498
Prkch^tm1Cda/Prkch^tm1Cda involves: 129S/SvEv * C57BL/6J	abnormal eyelid aperture	J:83498
	decreased body weight	J:83498
	epidermal hyperplasia	J:83498
	increased incidence of tumors by chemical induction	J:83498
	increased skin papilloma incidence	J:83498
	postnatal lethality, incomplete penetrance	J:83498

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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