Prkcq Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Prkcq
protein kinase C, theta
MGI:97601

55 phenotypes from 6 alleles in 9 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Prkcq^m1Btlr/Prkcq^m1Btlr C57BL/6J-Prkcq^m1Btlr	decreased IgG level	J:255214
Prkcq^m1Btlr/Prkcq^m1Btlr C57BL/6J-Prkcq^m1Btlr	impaired humoral immune response	J:255214
Prkcq^m2Btlr/Prkcq^m2Btlr C57BL/6J-Prkcq^m2Btlr	decreased IgG level	J:255216
Prkcq^m2Btlr/Prkcq^m2Btlr C57BL/6J-Prkcq^m2Btlr	impaired humoral immune response	J:255216
Prkcq^rpea1/Prkcq^rpea1 B6.ABJ-Prkcq^rpea1/BocJ	abnormal choroid vasculature morphology	J:237976
	abnormal eye electrophysiology	J:237977
	abnormal ocular fundus morphology	J:237977
	abnormal photoreceptor outer segment morphology	J:237976
	abnormal retina blood vessel morphology	J:237977
	abnormal retina cone cell morphology	J:237977
	abnormal retina cone cell outer segment morphology	J:237976
	abnormal retina pigmentation	J:237977
	retina detachment	J:237976, J:237977
	retina pigment epithelium atrophy	J:237977
	serous retina detachment	J:237977
Prkcq^{tm1.1(KOMP)Vlcg}/Prkcq^{tm1.1(KOMP)Vlcg} C57BL/6N-Prkcq^{tm1.1(KOMP)Vlcg}/Ucd	abnormal testis morphology	J:211773
	male infertility	J:211773
	small testis	J:211773
Prkcq^tm1.1Bai/Prkcq^tm1.1Bai involves: 129P2/OlaHsd * C57BL/6J	abnormal T cell physiology	J:83733
	decreased interleukin-2 secretion	J:83733
	decreased T cell proliferation	J:83733
Prkcq^tm1Litt/Prkcq⁺ B6.129P2-Prkcq^tm1Litt	abnormal neuromuscular synapse morphology	J:96919
Prkcq^tm1Litt/Prkcq^tm1Litt B6.129P2-Prkcq^tm1Litt	abnormal CD4-positive, alpha-beta T cell physiology	J:94285
	abnormal endplate potential	J:96919
	abnormal nervous system development	J:96919
	abnormal neuromuscular synapse morphology	J:96919
	abnormal ocular fundus morphology	J:237977
	abnormal T-helper 1 cell differentiation	J:94285
	abnormal T-helper 2 physiology	J:94285
	decreased airway responsiveness	J:94285
	decreased eye pigmentation	J:237977
	decreased interferon-gamma secretion	J:94285, J:129421
	decreased interleukin-2 secretion	J:94285, J:129421
	decreased interleukin-4 secretion	J:94285, J:129421
	decreased interleukin-5 secretion	J:94285
	decreased interleukin-13 secretion	J:94285
	decreased interleukin-17 secretion	J:129421
	decreased physiological sensitivity to xenobiotic	J:94285
	decreased splenocyte proliferation	J:129421
	decreased susceptibility to experimental autoimmune encephalomyelitis	J:129421
	decreased T cell proliferation	J:94285
	normal immune system phenotype	J:94285
	retina degeneration	J:237977
	retina detachment	J:237977
Prkcq^tm1Litt/Prkcq^tm1Litt either: (involves: 129/Sv * 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)	abnormal response to infection	J:141930
	decreased T cell apoptosis	J:141930
	decreased T cell proliferation	J:141930
Prkcq^tm1Litt/Prkcq^tm1Litt involves: 129P2/OlaHsd	abnormal T cell activation	J:83922
	decreased interleukin-2 secretion	J:83922
	decreased T cell proliferation	J:83922, J:123989
	normal immune system phenotype	J:123989
Prkcq^tm1Litt/Prkcq^tm1Litt involves: 129P2/OlaHsd * C57BL/6	abnormal adipocyte glucose uptake	J:92834
	abnormal effector T cell morphology	J:186080
	abnormal glucose homeostasis	J:92834
	abnormal muscle cell glucose uptake	J:92834
	abnormal positive T cell selection	J:186080
	decreased CD4-positive, alpha-beta T cell number	J:186080
	decreased CD8-positive, alpha-beta T cell number	J:186080
	decreased DN1 thymic pro-T cell number	J:186080
	decreased NK T cell number	J:141128
	decreased T cell proliferation	J:186080
	normal immune system phenotype	J:141128
	increased insulin sensitivity	J:92834
	increased T cell apoptosis	J:141128
Prkcq^tm1Litt/Prkcq^tm1Litt involves: 129P2/OlaHsd * C57BL/6J	abnormal platelet activation	J:144254
	abnormal platelet dense granule physiology	J:144254
	abnormal platelet physiology	J:144254
	increased platelet aggregation	J:144254

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