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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Prkcq
protein kinase C, theta
MGI:97601
55 phenotypes from 6 alleles in 9 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Prkcqm1Btlr/Prkcqm1Btlr
C57BL/6J-Prkcqm1Btlr 		decreased IgG level J:255214
impaired humoral immune response J:255214
Prkcqm2Btlr/Prkcqm2Btlr
C57BL/6J-Prkcqm2Btlr 		decreased IgG level J:255216
impaired humoral immune response J:255216
Prkcqrpea1/Prkcqrpea1
B6.ABJ-Prkcqrpea1/BocJ 		abnormal choroid vasculature morphology J:237976
abnormal eye electrophysiology J:237977
abnormal ocular fundus morphology J:237977
abnormal photoreceptor outer segment morphology J:237976
abnormal retina blood vessel morphology J:237977
abnormal retina cone cell morphology J:237977
abnormal retina cone cell outer segment morphology J:237976
abnormal retina pigmentation J:237977
retina detachment J:237976, J:237977
retina pigment epithelium atrophy J:237977
serous retina detachment J:237977
Prkcqtm1.1(KOMP)Vlcg/Prkcqtm1.1(KOMP)Vlcg
C57BL/6N-Prkcqtm1.1(KOMP)Vlcg/Ucd 		abnormal testis morphology J:211773
male infertility J:211773
small testis J:211773
Prkcqtm1.1Bai/Prkcqtm1.1Bai
involves: 129P2/OlaHsd * C57BL/6J 		abnormal T cell physiology J:83733
decreased interleukin-2 secretion J:83733
decreased T cell proliferation J:83733
Prkcqtm1Litt/Prkcq+
B6.129P2-Prkcqtm1Litt 		abnormal neuromuscular synapse morphology J:96919
Prkcqtm1Litt/Prkcqtm1Litt
B6.129P2-Prkcqtm1Litt 		abnormal CD4-positive, alpha-beta T cell physiology J:94285
abnormal endplate potential J:96919
abnormal nervous system development J:96919
abnormal neuromuscular synapse morphology J:96919
abnormal ocular fundus morphology J:237977
abnormal T-helper 1 cell differentiation J:94285
abnormal T-helper 2 physiology J:94285
decreased airway responsiveness J:94285
decreased eye pigmentation J:237977
decreased interferon-gamma secretion J:94285, J:129421
decreased interleukin-2 secretion J:94285, J:129421
decreased interleukin-4 secretion J:94285, J:129421
decreased interleukin-5 secretion J:94285
decreased interleukin-13 secretion J:94285
decreased interleukin-17 secretion J:129421
decreased physiological sensitivity to xenobiotic J:94285
decreased splenocyte proliferation J:129421
decreased susceptibility to experimental autoimmune encephalomyelitis J:129421
decreased T cell proliferation J:94285
normal immune system phenotype J:94285
retina degeneration J:237977
retina detachment J:237977
Prkcqtm1Litt/Prkcqtm1Litt
either: (involves: 129/Sv * 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) 		abnormal response to infection J:141930
decreased T cell apoptosis J:141930
decreased T cell proliferation J:141930
Prkcqtm1Litt/Prkcqtm1Litt
involves: 129P2/OlaHsd 		abnormal T cell activation J:83922
decreased interleukin-2 secretion J:83922
decreased T cell proliferation J:83922, J:123989
normal immune system phenotype J:123989
Prkcqtm1Litt/Prkcqtm1Litt
involves: 129P2/OlaHsd * C57BL/6 		abnormal adipocyte glucose uptake J:92834
abnormal effector T cell morphology J:186080
abnormal glucose homeostasis J:92834
abnormal muscle cell glucose uptake J:92834
abnormal positive T cell selection J:186080
decreased CD4-positive, alpha-beta T cell number J:186080
decreased CD8-positive, alpha-beta T cell number J:186080
decreased DN1 thymic pro-T cell number J:186080
decreased NK T cell number J:141128
decreased T cell proliferation J:186080
normal immune system phenotype J:141128
increased insulin sensitivity J:92834
increased T cell apoptosis J:141128
Prkcqtm1Litt/Prkcqtm1Litt
involves: 129P2/OlaHsd * C57BL/6J 		abnormal platelet activation J:144254
abnormal platelet dense granule physiology J:144254
abnormal platelet physiology J:144254
increased platelet aggregation J:144254
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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08/02/2024
MGI 6.24 		The Jackson Laboratory