Prkcq Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Prkcq
protein kinase C, theta
MGI:97601

32 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Crb1^rd8/Crb1^rd8 Prkcq^tm1Litt/Prkcq^tm1Litt B6.129P2-Prkcq^tm1Litt	abnormal ocular fundus morphology	J:237977
	decreased eye pigmentation	J:237977
	retina degeneration	J:237977
	retina detachment	J:237977
Pde6b^rd1/Pde6b^rd1 Prkcq^rpea1/Prkcq^rpea1 ABJ/LeJ-Prkcq^rpea1/Boc	abnormal ocular fundus morphology	J:237977
	buphthalmos	J:237977
	cataract	J:237977
	decreased retina ganglion cell number	J:237977
	decreased retina photoreceptor cell number	J:237977
	ocular hypertension	J:237977
Pde6b^rd1/Pde6b^rd1 Prkcq^rpea1/Prkcq^rpea1 B6.ABJ-Prkcq^rpea1 Pde6b^rd1/Boc	abnormal ocular fundus morphology	J:237977
	buphthalmos	J:237977
	cataract	J:237977
	decreased retina ganglion cell number	J:237977
	decreased retina photoreceptor cell number	J:237977
	ocular hypertension	J:237977
	retina detachment	J:237977
	serous retina detachment	J:237977
Prkch^tm1.2Gasc/Prkch^tm1.2Gasc Prkcq^tm1Litt/Prkcq^tm1Litt involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL	abnormal positive T cell selection	J:186080
	decreased CD4-positive, alpha-beta T cell number	J:186080
	decreased CD8-positive, alpha-beta T cell number	J:186080
	decreased DN1 thymic pro-T cell number	J:186080
	decreased DN4 thymocyte number	J:186080
	decreased double-negative T cell number	J:186080
	decreased double-positive T cell number	J:186080
	decreased T cell proliferation	J:186080
	normal immune system phenotype	J:186080
Prkcq^tm1Litt/Prkcq^tm1Litt Tcra^tm1Mom/Tcra^tm1Mom involves: 129P2/OlaHsd * 129S2/SvPas	decreased interleukin-4 secretion	J:135589
	decreased T cell proliferation	J:135589
	normal digestive/alimentary phenotype	J:135589
	normal immune system phenotype	J:135589
Prkcq^tm1Litt/Prkcq^tm1Litt Tg(DO11.10)10Dlo/0 involves: 129 * BALB/c * C3H * C57BL/6	decreased T cell apoptosis	J:141930
Prkcq^tm1Litt/Prkcq^tm1Litt Tg(Lck-Notch3)#Issc/0 involves: 129P2/OlaHsd * C57BL/6 * DBA/2	decreased lymphoma incidence	J:96010
	enlarged chest	J:96010
	enlarged spleen	J:96010
	extended life span	J:96010
	increased spleen weight	J:96010
	premature death	J:96010
Prkcq^tm1Litt/Prkcq^tm1Litt Tg(LCKprBCL2L1)12Sjk/0 involves: 129P2/OlaHsd * C57BL/6	decreased NK T cell number	J:141128
	normal immune system phenotype	J:141128
Prkcq^tm1Litt/Prkcq^tm1Litt Tg(TcrLCMV)327Sdz/0 involves: 129P2/OlaHsd * C57BL/6 * DBA/2	abnormal T cell anergy	J:123989
	decreased cytotoxic T cell cytolysis	J:123989
	decreased splenocyte proliferation	J:123989
	decreased T cell proliferation	J:123989

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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