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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Pkd1
polycystin 1, transient receptor potential channel interacting
MGI:97603
223 phenotypes from 36 alleles in 46 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Pkd1b2b1585Clo/Pkd1b2b1585Clo
C57BL/6J-Pkd1b2b1585Clo 		heart left ventricle hypertrophy J:175213
heart right ventricle hypertrophy J:175213
micrognathia J:175213
polycystic kidney J:175213
Pkd1m1Bei/Pkd1m1Bei
involves: A/J * FVB/N 		edema J:75360
enlarged kidney J:75360
enlarged pancreas J:75360
kidney cyst J:75360, J:213263
Pkd1tm1.1Bol/Pkd1tm1.1Bol
Not Specified 		no abnormal phenotype detected J:148419
Pkd1tm1.1Djmp/Pkd1tm1.1Djmp
involves: 129P2/OlaHsd * C57BL/6 		no abnormal phenotype detected J:94582
Pkd1tm1.1Djmp/Pkd1tm1.1Djmp
Tg(Cdh16-cre/ERT2)F427Djmp/0
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NCrl * FVB/N 		kidney cyst J:130079
Pkd1tm1.1Djmp/Pkd1tm1.2Djmp
Tg(Cdh16-cre/ERT2)F427Djmp/0
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NCrl * FVB/N 		dilated renal tubule J:130079
increased kidney cell proliferation J:130079
increased kidney weight J:130079
kidney cyst J:130079
liver cyst J:130079
pale kidney J:130079
polycystic kidney J:130079
Pkd1tm1.1Fqi/Pkd1tm1.1Fqi
B6.129S6-Pkd1tm1.1Fqi 		abnormal common bile duct morphology J:127628
dilated renal tubule J:127628
distended abdomen J:127628
enlarged kidney J:127628
increased blood urea nitrogen level J:127628
polycystic kidney J:127628
postnatal lethality J:127628
premature death J:127628
weight loss J:127628
Pkd1tm1.1Fqi/Pkd1tm1.1Fqi
involves: 129S6/SvEvTac 		enlarged kidney J:193175
increased blood urea nitrogen level J:193175
increased circulating creatinine level J:193175
polycystic kidney J:193175
Pkd1tm1.1Pcha/Pkd1tm1.1Pcha
involves: 129S1/Sv * C57BL/6 		abnormal kidney collecting duct morphology J:193544
dilated proximal convoluted tubule J:193544
enlarged kidney J:193544
increased blood urea nitrogen level J:193544
increased kidney weight J:193544
increased renal hamartoma incidence J:193544
polycystic kidney J:193544
renal fibrosis J:193544
Pkd1tm1.1Pcha/Pkd1tm2Som
Tg(Cdh16-cre)91Igr/0
involves: 129 * 129S4/SvJae * C57BL/6 * ICR 		abnormal kidney physiology J:244067
abnormal peroxisome morphology J:244067
decreased fatty acid oxidation J:244067
increased circulating creatinine level J:244067
increased kidney cell proliferation J:244067
oxidative stress J:244067
polycystic kidney J:244067
premature death J:244067
renal interstitial fibrosis J:244067
Pkd1tm1.2Bol/Pkd1tm1.2Bol
Not Specified 		prenatal lethality, complete penetrance J:148419
Pkd1tm1.2Djmp/Pkd1+
involves: 129P2/OlaHsd * FVB/N 		increased kidney cell proliferation J:130079
Pkd1tm1.2Djmp/Pkd1tm1.2Djmp
involves: 129P2/OlaHsd * FVB/N 		prenatal lethality, complete penetrance J:130079
Pkd1tm1b(EUCOMM)Hmgu/Pkd1+
C57BL/6N-Pkd1tm1b(EUCOMM)Hmgu/Bay 		decreased circulating alkaline phosphatase level J:211773
decreased circulating total protein level J:211773
decreased erythrocyte cell number J:211773
decreased hematocrit J:211773
increased neutrophil cell number J:211773
Pkd1tm1b(EUCOMM)Hmgu/Pkd1tm1b(EUCOMM)Hmgu
C57BL/6N-Pkd1tm1b(EUCOMM)Hmgu/Bay 		preweaning lethality, complete penetrance J:211773
Pkd1tm1Bdgz/Pkd1+
involves: 129S1/Sv * 129X1/SvJ 		dilated renal tubule J:130086
kidney cyst J:130086
liver cyst J:130086
pancreas cyst J:130086
Pkd1tm1Bdgz/Pkd1tm1Bdgz
involves: 129S1/Sv * 129X1/SvJ 		kidney cyst J:130086
lethality throughout fetal growth and development, complete penetrance J:130086
pancreas cyst J:130086
skin edema J:130086
Pkd1tm1Djmp/Pkd1tm1Djmp
involves: 129P2/OlaHsd * C57BL/6 		aortic aneurysm J:94582
aortic dissection J:94582
biliary cyst J:94582
decreased body weight J:94582
dilated bile duct J:94582
distended abdomen J:94582
kidney cyst J:94582
kidney inflammation J:94582
pancreas cyst J:94582
postnatal growth retardation J:94582
premature death J:94582
renal interstitial fibrosis J:94582
Pkd1tm1Fqi/Pkd1tm1Fqi
involves: 129S6/SvEvTac * C57BL/6 		prenatal lethality, complete penetrance J:127628
Pkd1tm1Ggg/Pkd1tm1Ggg
either: (involves: 129/Sv) or (involves: 129/Sv * Black Swiss) 		abnormal amniotic fluid composition J:104483
polyhydramnios J:104483
Pkd1tm1Ggg/Pkd1tm1Ggg
involves: 129/Sv * Black Swiss 		edema J:103719
hemorrhage J:103719
polyhydramnios J:103719
prenatal lethality, complete penetrance J:103719
Pkd1tm1Ggg/Pkd1tm1Ggg
involves: 129S4/SvJae * C57BL/6 		abnormal placenta development J:165114
abnormal placenta morphology J:165114
abnormal placenta vasculature J:165114
lethality throughout fetal growth and development, incomplete penetrance J:165114
polyhydramnios J:165114
Pkd1tm1Ggg/Pkd1tm1Ggg
Not Specified 		kidney cyst J:76062
lethality throughout fetal growth and development, complete penetrance J:76062
pancreas cyst J:76062
Pkd1tm1Ggg/Pkd1tm2.1Ggg
involves: 129S4/SvJae * Black Swiss * C57BL/6 		edema J:103719
hemorrhage J:103719
polyhydramnios J:103719
prenatal lethality, complete penetrance J:103719
Pkd1tm1Ggg/Pkd1tm2Ggg
Meox2tm1(cre)Sor/Meox2+
involves: 129S4/SvJae * 129S4/SvJaeSor 		abnormal placenta morphology J:165114
abnormal placenta vasculature J:165114
normal cardiovascular system phenotype J:165114
edema J:165114
kidney cyst J:165114
lethality throughout fetal growth and development, incomplete penetrance J:165114
neonatal lethality, complete penetrance J:165114
polyhydramnios J:165114
respiratory failure J:165114
Pkd1tm1Ggg/Pkd1tm2Ggg
Tg(Col1a1-cre)1Bek/0
involves: 129S4/SvJae * CD-1 		abnormal bone mineralization J:191967
decreased bone mineral density J:191967
decreased compact bone thickness J:191967
decreased trabecular bone volume J:191967
perinatal lethality J:191967
short femur J:191967
Pkd1tm1Ggg/Pkd1tm2Ggg
Tg(Tek-cre)1Ywa/0
involves: 129S4/SvJae * C57BL/6 * SJL 		abnormal placenta vasculature J:165114
hemorrhage J:165114
normal homeostasis/metabolism phenotype J:165114
perinatal lethality, incomplete penetrance J:165114
polyhydramnios J:165114
Pkd1tm1Gztn/Pkd1tm1Gztn
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
involves: 129S/Sv * 129S7/SvEvBrd * C57BL/6 		abnormal kidney physiology J:162080
polycystic kidney J:162080
Pkd1tm1Hung/Pkd1tm1Hung
either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB) 		abnormal kidney morphology J:104361
abnormal skeleton development J:104361
normal cardiovascular system phenotype J:104361
decreased body size J:104361
decreased body weight J:104361
distended abdomen J:104361
enlarged kidney J:104361
increased blood urea nitrogen level J:104361
infertility J:104361
kidney cyst J:104361
normal liver/biliary system phenotype J:104361
pancreas cyst J:104361
postnatal growth retardation J:104361
premature death J:104361
renal interstitial fibrosis J:104361
normal respiratory system phenotype J:104361
Pkd1tm1Jzh/Pkd1+
either: (involves: 129S4/SvJae * C57BL/6) or (involves: 129S4/SvJae * BALB/c) 		abnormal bile duct morphology J:52573
abnormal circulating creatinine level J:52573
abnormal exocrine pancreas morphology J:72627
abnormal pancreatic acinus morphology J:72627
bile duct inflammation J:52573
decreased liver function J:52573
decreased pancreatic islet number J:72627
dilated pancreatic duct J:72627
dilated renal tubule J:52573
dissociated hepatocytes J:52573
exocrine pancreas atrophy J:72627
normal homeostasis/metabolism phenotype J:52573
kidney cyst J:52573
kidney inflammation J:52573
liver cyst J:52573
pancreas cyst J:72627
pancreas fibrosis J:72627
pancreas lipomatosis J:72627
renal interstitial fibrosis J:52573
normal renal/urinary system phenotype J:43193
Pkd1tm1Jzh/Pkd1tm1Jzh
either: (involves: 129S4/SvJae * C57BL/6) or (involves: 129S4/SvJae * BALB/c) 		abnormal bone mineralization J:72627
abnormal kidney epithelial cell primary cilium physiology J:81443
abnormal kidney epithelium morphology J:81443
abnormal thyroid cartilage morphology J:72627
normal cardiovascular system phenotype J:72627
chondrodystrophy J:72627
decreased pancreatic islet number J:43193
dilated pancreatic duct J:43193
dilated proximal convoluted tubule J:43193
disproportionate dwarf J:43193, J:72627
distended abdomen J:43193
normal endocrine/exocrine gland phenotype J:43193
enlarged kidney J:43193
normal hematopoietic system phenotype J:72627
hydrops fetalis J:72627
kidney cortex cyst J:43193
kidney cyst J:43193, J:81443
kidney medulla cyst J:43193
normal liver/biliary system phenotype J:43193
pancreas cyst J:43193
perinatal lethality, incomplete penetrance J:43193
polyhydramnios J:72627
postnatal lethality, complete penetrance J:43193
pulmonary hypoplasia J:43193
normal renal/urinary system phenotype J:43193
respiratory distress J:43193
skin edema J:72627
small lung J:43193
spina bifida occulta J:72627
Pkd1tm1Maa/Pkd1tm1Maa
involves: 129S4/SvJae * C57BL/6 		abnormal blood vessel morphology J:68331
hemorrhage J:68331
hydrops fetalis J:68331
kidney cyst J:68331
lethality throughout fetal growth and development, complete penetrance J:68331
pancreas cyst J:68331
skin edema J:68331
Pkd1tm1Rsa/Pkd1+
involves: 129S4/SvJaeSor 		kidney cyst J:72238
liver cyst J:72238
Pkd1tm1Rsa/Pkd1tm1Rsa
involves: 129S4/SvJaeSor 		abnormal cartilage development J:72238
abnormal conotruncal ridge morphology J:72238
abnormal craniofacial bone morphology J:72238
abnormal Meckel's cartilage morphology J:72238
abnormal myocardial trabeculae morphology J:72238
abnormal radius morphology J:72238
abnormal spine curvature J:72238
abnormal ulna morphology J:72238
abnormal vertebrae morphology J:72238
atrial septal defect J:72238
common atrioventricular valve J:72238
decreased length of long bones J:72238
double outlet right ventricle J:72238
edema J:72238
failure of atrioventricular cushion closure J:72238
hemopericardium J:72238
hemorrhage J:72238
lethality throughout fetal growth and development, complete penetrance J:72238
thin myocardium J:72238
ventricular septal defect J:72238
Pkd1tm1Shh/Pkd1tm1.1Pcha
involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 		decreased bone mineral density J:193544
decreased compact bone mass J:193544
decreased trabecular bone mass J:193544
enlarged kidney J:193544
heart left ventricle hypertrophy J:193544
increased activity of parathyroid J:193544
increased blood urea nitrogen level J:193544
increased cell proliferation J:193544
increased heart weight J:193544
increased kidney epithelial cell primary cilium length J:193544
increased kidney weight J:193544
kidney failure J:193544
polycystic kidney J:193544
premature death J:193544
renal fibrosis J:193544
thick myocardium J:193544
uremia J:193544
Pkd1tm1Shh/Pkd1tm1Shh
involves: 129P2/OlaHsd * C57BL/6J 		double outlet right ventricle J:77927
kidney cyst J:77927
lethality throughout fetal growth and development, incomplete penetrance J:77927
skin edema J:77927
Pkd1tm1Som/Pkd1+
involves: 129/Sv * C57BL/6 * SJL 		kidney cyst J:78422
Pkd1tm1Som/Pkd1+
Tg(Pkd1*)39Mtru/0
involves: 129/Sv * C57BL/6J * CBA/J * SJL 		dilated renal tubule J:198147
polycystic kidney J:198147
Pkd1tm1Som/Pkd1tm1Som
involves: 129/Sv * C57BL/6 * SJL 		normal cardiovascular system phenotype J:78422
decreased embryo size J:78422
edema J:78422
embryonic lethality during organogenesis, incomplete penetrance J:78422
hemorrhage J:78422
kidney cyst J:78422
neonatal lethality, complete penetrance J:78422
pallor J:78422
pancreas cyst J:78422
Pkd1tm1Som/Pkd1tm2Som
Tg(Cdh16-cre/ERT2)24Igr/?
involves: 129/Sv * C57BL/6 * SJL 		abnormal mitotic spindle morphology J:185863
Pkd1tm2.1Bol/Pkd1tm2.1Bol
involves: 129S2/SvPas * C57BL/6 * C57BL/6NTac 		no abnormal phenotype detected J:153606
Pkd1tm2.1Bol/Pkd1tm2.2Bol
involves: 129S2/SvPas * C57BL/6 * C57BL/6NTac 		no abnormal phenotype detected J:153606
Pkd1tm2.1Bol/Pkd1tm3.2Bol
involves: 129S2/SvPas * C57BL/6 * C57BL/6NTac 		no abnormal phenotype detected J:153606
Pkd1tm2.1Ggg/Pkd1tm2.1Ggg
involves: 129S4/SvJae * Black Swiss * C57BL/6 		abnormal fluid regulation J:103719
hemorrhage J:103719
kidney cyst J:103719
pancreas cyst J:103719
prenatal lethality, complete penetrance J:103719
Pkd1tm2.1Som/Pkd1tm2.1Som
involves: C57BL/6 * FVB/N * SJL 		embryonic lethality during organogenesis J:135301
Pkd1tm2.2Bol/Pkd1tm2.2Bol
involves: 129S2/SvPas * C57BL/6 * C57BL/6NTac 		abnormal brain vasculature morphology J:153606
dilated lateral ventricle J:153606
dilated third ventricle J:153606
edema J:153606
hemorrhage J:153606
hydrocephaly J:153606
kidney cyst J:153606
lethality throughout fetal growth and development, complete penetrance J:153606
Pkd1tm2.2Bol/Pkd1tm3.1Bol
involves: 129S2/SvPas * C57BL/6 * C57BL/6NTac 		no abnormal phenotype detected J:153606
Pkd1tm2.2Bol/Pkd1tm3.1Bol
Tg(Nes-cre)1Kln/0
involves: 129S2/SvPas * C57BL/6 * C57BL/6NTac * SJL 		abnormal brain ventricle morphology J:153606
dilated lateral ventricle J:153606
dilated third ventricle J:153606
hydrocephaly J:153606
kidney cyst J:153606
kidney failure J:153606
postnatal lethality, complete penetrance J:153606
Pkd1tm2Ggg/Pkd1+
Tg(Col1a1-cre)1Bek/0
involves: 129S4/SvJae * CD-1 		decreased bone mineral density J:191967
decreased bone mineralization J:191967
decreased compact bone thickness J:191967
decreased trabecular bone volume J:191967
normal endocrine/exocrine gland phenotype J:191967
impaired osteoblast differentiation J:191967
increased osteoblast proliferation J:191967
normal renal/urinary system phenotype J:191967
Pkd1tm2Ggg/Pkd1+
Tg(Pax8-rtTA2S*M2)1Koes/0
Tg(tetO-cre)1Jaw/0
involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA * SJL 		normal renal/urinary system phenotype J:284006
Pkd1tm2Ggg/Pkd1tm2Ggg
Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 		increased kidney weight J:213263
Pkd1tm2Ggg/Pkd1tm2Ggg
Tg(Col1a1-cre)1Bek/0
involves: 129S4/SvJae * CD-1 		abnormal adipose tissue development J:191967
abnormal bone marrow morphology J:191967
abnormal circulating mineral level J:191967
abnormal exocrine pancreas morphology J:191967
abnormal osteoblast differentiation J:191967
decreased body size J:191967
decreased body weight J:191967
decreased bone mineral density J:191967
decreased bone mineralization J:191967
decreased compact bone thickness J:191967
decreased trabecular bone volume J:191967
increased blood urea nitrogen level J:191967
increased circulating parathyroid hormone level J:191967
increased osteoblast proliferation J:191967
pancreas cyst J:191967
polycystic kidney J:191967
postnatal lethality, incomplete penetrance J:191967
premature death J:191967
renal fibrosis J:191967
short femur J:191967
Pkd1tm2Ggg/Pkd1tm2Ggg
Tg(Hoxb7-cre)13Amc/0
involves: 129S4/SvJae * C57BL/6 		increased blood urea nitrogen level J:171619
increased kidney apoptosis J:171619
increased kidney cell proliferation J:171619
polycystic kidney J:171619
Pkd1tm2Ggg/Pkd1tm2Ggg
Tg(MMTV-cre)4Mam/0
involves: 129S4/SvJae * FVB 		kidney cyst J:103719
liver cyst J:103719
Pkd1tm2Ggg/Pkd1tm2Ggg
Tg(Nes-cre)Wme/0
involves: 129S4/SvJae * C57BL/6 * CBA 		abnormal kidney morphology J:185855
enlarged kidney J:185855
increased blood urea nitrogen level J:185855
increased kidney apoptosis J:185855
increased kidney cell proliferation J:185855
kidney cyst J:185855
renal fibrosis J:185855
Pkd1tm2Ggg/Pkd1tm2Ggg
Tg(Pax8-rtTA2S*M2)1Koes/0
Tg(tetO-cre)1Jaw/0
involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA * SJL 		increased blood urea nitrogen level J:284006
increased kidney weight J:284006
polycystic kidney J:284006
Pkd1tm2Jzh/Pkd1+
either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6) 		kidney cyst J:72627
liver cyst J:72627
pancreas cyst J:72627
Pkd1tm2Jzh/Pkd1tm2Jzh
either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6) 		abnormal bone marrow cavity morphology J:72627
abnormal bone mineralization J:72627
abnormal skeleton development J:72627
abnormal thyroid cartilage morphology J:72627
chondrodystrophy J:72627
decreased length of long bones J:72627
decreased width of hypertrophic chondrocyte zone J:72627
delayed endochondral bone ossification J:72627
delayed intramembranous bone ossification J:72627
disproportionate dwarf J:72627
hydrops fetalis J:72627
lethality throughout fetal growth and development, incomplete penetrance J:72627
pancreas cyst J:72627
perinatal lethality, complete penetrance J:72627
polycystic kidney J:72627
polyhydramnios J:72627
skin edema J:72627
spina bifida occulta J:72627
Pkd1tm2Jzh/Pkd1tm2Jzh
involves: 129S4/SvJae * C57BL/6 		edema J:140012
lethality throughout fetal growth and development, incomplete penetrance J:140012
neonatal lethality, complete penetrance J:140012
polycystic kidney J:140012
polyhydramnios J:140012
Pkd1tm2Pcha/Pkd1tm2Pcha
involves: C57BL/6 		lethality, complete penetrance J:220561
Pkd1tm2Som/Pkd1tm2.1Som
Tg(Cdh16-cre)91Igr/0
involves: C57BL/6 * ICR * SJL 		abnormal kidney morphology J:135301
decreased circulating glucose level J:135301
increased blood urea nitrogen level J:135301
increased circulating cholesterol level J:135301
increased circulating phosphate level J:135301
increased kidney weight J:135301
kidney failure J:135301
polycystic kidney J:135301
postnatal lethality, complete penetrance J:135301
Pkd1tm2Som/Pkd1tm2Som
Tg(Cdh16-cre)91Igr/0
involves: 129S4/SvJae * C57BL/6 * ICR 		increased circulating creatinine level J:244067
increased kidney cell proliferation J:244067
polycystic kidney J:244067
postnatal lethality, complete penetrance J:244067
Pkd1tm2Som/Pkd1tm2Som
Tg(Cdh16-cre)91Igr/0
involves: C57BL/6 * ICR * SJL 		abnormal kidney morphology J:135301
decreased circulating glucose level J:135301
increased blood urea nitrogen level J:135301
increased circulating cholesterol level J:135301
increased circulating phosphate level J:135301
increased kidney weight J:135301
kidney failure J:135301
polycystic kidney J:135301
postnatal lethality, complete penetrance J:135301
Pkd1tm2Som/Pkd1tm2Som
Tg(Pkhd1-cre)1Igr/0
involves: C57BL/6 * SJL 		abnormal kidney morphology J:135301
kidney cyst J:135301
Pkd1tm3.1Bol/Pkd1tm3.1Bol
involves: 129S2/SvPas * C57BL/6 * C57BL/6NTac 		no abnormal phenotype detected J:153606
Pkd1tm3.1Bol/Pkd1tm3.2Bol
involves: 129S2/SvPas * C57BL/6 * C57BL/6NTac 		no abnormal phenotype detected J:153606
Pkd1tm3.1Jzh/Pkd1tm3.1Jzh
involves: 129P2/OlaHsd * C57BL/6 		edema J:140012
neonatal lethality, complete penetrance J:140012
polycystic kidney J:140012
polyhydramnios J:140012
prenatal lethality, incomplete penetrance J:140012
Pkd1tm3.2Bol/Pkd1tm3.2Bol
involves: 129S2/SvPas * C57BL/6 * C57BL/6NTac 		abnormal brain vasculature morphology J:153606
dilated lateral ventricle J:153606
dilated third ventricle J:153606
edema J:153606
hemorrhage J:153606
hydrocephaly J:153606
kidney cyst J:153606
lethality throughout fetal growth and development, complete penetrance J:153606
Pkd1tm3Jzh/Pkd1tm3Jzh
involves: 129P2/OlaHsd * 129X1/SvJ 		abnormal basicranium morphology J:139970
abnormal sphenoid bone morphology J:139970
abnormal sphenooccipital synchondrosis J:139970
decreased chondrocyte proliferation J:139970
delayed bone ossification J:139970
domed cranium J:139970
polycystic kidney J:139970
premature presphenoid synchondrosis closure J:139970
premature sphenooccipital synchondrosis closure J:139970
short presphenoid bone J:139970
slow postnatal weight gain J:139970
Pkd1tm3Jzh/Pkd1tm3Jzh
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129P2/OlaHsd * C57BL/6 * CBA 		abnormal craniofacial bone morphology J:139970
abnormal perichondrium morphology J:139970
abnormal presphenoid synchondrosis J:139970
abnormal sphenoid bone morphology J:139970
decreased chondrocyte proliferation J:139970
delayed intramembranous bone ossification J:139970
domed cranium J:139970
malocclusion J:139970
maxilla hypoplasia J:139970
nasal bone hypoplasia J:139970
premature presphenoid synchondrosis closure J:139970
short frontal bone J:139970
short mandible J:139970
short maxilla J:139970
short nasal bone J:139970
short premaxilla J:139970
short presphenoid bone J:139970
short snout J:139970
Pkd1tm3Jzh/Pkd1tm3Jzh
Tg(Col2a1-cre)10Amc/0
involves: 129P2/OlaHsd 		abnormal compact bone morphology J:140779
delayed intramembranous bone ossification J:140779
polycystic kidney J:140779
postnatal lethality, complete penetrance J:140779
premature cranial synchondrosis closure J:140779
Pkd1tm3Jzh/Pkd1tm3Jzh
Tg(Ggt1-cre)M3Egn/0
involves: 129P2/OlaHsd * C57BL/6 * SJL 		increased renal tubule apoptosis J:140012
polycystic kidney J:140012
premature death J:140012
Pkd1tm3Jzh/Pkd1tm3Jzh
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/?
involves: 129P2/OlaHsd * CD-1 		delayed intramembranous bone ossification J:139970
Tg(Pkd1)6Mtru/0
involves: C57BL/6J * CBA/J 		abnormal aortic valve cusp morphology J:157952
abnormal renal tubule epithelium morphology J:157952
cardiac hypertrophy J:157952
decreased hematocrit J:157952
decreased urine creatinine level J:157952
decreased urine urea nitrogen level J:157952
dilated heart J:157952
dilated renal tubule J:157952
glomerulosclerosis J:157952
heart left ventricle hypertrophy J:157952
hematuria J:157952
increased blood osmolality J:157952
increased cardiac muscle contractility J:157952
increased circulating sodium level J:157952
increased heart weight J:157952
increased hepatocyte proliferation J:157952
increased kidney cell proliferation J:157952
increased urine osmolality J:157952
increased urine protein level J:157952
kidney cortex cyst J:157952
kidney cyst J:157952
kidney epithelium hyperplasia J:157952
kidney medulla cyst J:157952
liver cyst J:157952
liver fibrosis J:157952
nephrocalcinosis J:157952
nephrolithiasis J:157952
pale kidney J:157952
polyuria J:157952
premature death J:157952
renal cast J:157952
renal interstitial fibrosis J:157952
thick interventricular septum J:157952
thick ventricular wall J:157952
Tg(Pkd1)18Mtru/0
involves: C57BL/6J * CBA/J 		cardiac fibrosis J:157952
decreased hematocrit J:157952
glomerulosclerosis J:157952
hypertension J:157952
increased urine protein level J:157952
kidney cortex cyst J:157952
kidney cyst J:157952
kidney medulla cyst J:157952
nephrocalcinosis J:157952
nephrolithiasis J:157952
pale kidney J:157952
premature death J:157952
Tg(Pkd1)26Mtru/0
involves: C57BL/6J * CBA/J 		abnormal aortic valve cusp morphology J:157952
abnormal cerebellum development J:157952
abnormal myocardium layer morphology J:157952
abnormal renal tubule epithelium morphology J:157952
abnormal sagittal suture morphology J:157952
aneurysm J:157952
aortic valve stenosis J:157952
calcified aortic valve J:157952
cardiac fibrosis J:157952
cardiac hypertrophy J:157952
decreased hematocrit J:157952
decreased urine protein level J:157952
dilated brain ventricle J:157952
dilated heart J:157952
dilated renal tubule J:157952
dystrophic cardiac calcinosis J:157952
glomerulosclerosis J:157952
heart left ventricle hypertrophy J:157952
hematuria J:157952
hydrocephaly J:157952
hypertension J:157952
increased blood osmolality J:157952
increased cardiac output J:157952
increased cardiac stroke volume J:157952
increased circulating phosphate level J:157952
increased circulating sodium level J:157952
increased heart weight J:157952
increased hepatocyte proliferation J:157952
increased kidney cell proliferation J:157952
increased urine protein level J:157952
kidney cortex cyst J:157952
kidney cyst J:157952
kidney epithelium hyperplasia J:157952
kidney medulla cyst J:157952
liver cyst J:157952
liver fibrosis J:157952
nephrocalcinosis J:157952
nephrolithiasis J:157952
pale kidney J:157952
polyuria J:157952
premature death J:157952
renal cast J:157952
renal interstitial fibrosis J:157952
small cerebellum J:157952
subarachnoid hemorrhage J:157952
thick interventricular septum J:157952
thick ventricular wall J:157952
Tg(Pkd1*)39Mtru/0
involves: C57BL/6J * CBA/J 		abnormal ion homeostasis J:198147
abnormal renal glomerulus morphology J:198147
decreased hematocrit J:198147
decreased urine creatinine level J:198147
decreased urine osmolality J:198147
decreased urine urea nitrogen level J:198147
dilated renal tubule J:198147
increased blood urea nitrogen level J:198147
increased circulating creatinine level J:198147
increased urine protein level J:198147
kidney failure J:198147
pale kidney J:198147
polycystic kidney J:198147
polyuria J:198147
premature death J:198147
renal glomerulus cyst J:198147
renal interstitial fibrosis J:198147
renal tubule atrophy J:198147
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory