Pklr Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pklr
pyruvate kinase liver and red blood cell
MGI:97604

28 phenotypes from 4 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Pklr^char4/Pklr^char4 involves: A/J * C57BL/6	abnormal erythrocyte morphology	J:86735
	abnormal erythropoiesis	J:141722
	anemia	J:141722
	decreased hemoglobin content	J:141722
	decreased susceptibility to parasitic infection	J:86735, J:141722
	decreased susceptibility to parasitic infection induced morbidity/mortality	J:141722
	enlarged spleen	J:86735
	hemolytic anemia	J:86735
	increased erythrocyte clearance	J:141722
	reticulocytosis	J:86735, J:141722
Pklr^em1Appsc/Pklr^em1Appsc involves: C57BL/6J	abnormal metabolism	J:342736
	abnormal sphingomyelin level	J:342736
	decreased ceramide level	J:342736
	decreased saturated fatty acids level	J:342736
	decreased susceptibility to diet-induced hepatic steatosis	J:342736
Pklr^M1Neu/Pklr^M1Neu involves: 101/El * C3H/El	no abnormal phenotype detected	J:65152
Pklr^slc/Pklr^slc CBA/NSlc-Pklr^slc	abnormal common myeloid progenitor cell morphology	J:30035
	abnormal enzyme/coenzyme activity	J:29199
	abnormal erythropoiesis	J:30035, J:141722
	anemia	J:141722
	decreased erythrocyte cell number	J:30035
	decreased hematocrit	J:30035
	decreased hemoglobin content	J:30035, J:141722
	decreased susceptibility to parasitic infection	J:141722
	decreased susceptibility to parasitic infection induced morbidity/mortality	J:141722
	enlarged spleen	J:30035
	hemolytic anemia	J:29199, J:30035
	hemosiderosis	J:30035
	increased circulating bilirubin level	J:30035
	increased erythroblast number	J:30035
	increased erythrocyte clearance	J:141722
	increased erythroid progenitor cell number	J:29199
	increased mean corpuscular volume	J:30035
	increased nucleated erythrocyte cell number	J:30035
	increased susceptibility to bacterial infection induced morbidity/mortality	J:128518
	reticulocytosis	J:30035, J:141722
Pklr^slc/Pklr^slc involves: CBA/NSlc	abnormal erythrocyte morphology	J:203909
	anemia	J:203909
	increased erythrocyte osmotic fragility	J:203909

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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