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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Serpine1
serine (or cysteine) peptidase inhibitor, clade E, member 1
MGI:97608
49 phenotypes from 4 alleles in 8 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Serpine1em1(IMPC)Tcp/Serpine1em1(IMPC)Tcp
C57BL/6N-Serpine1em1(IMPC)Tcp/Tcp 		abnormal sternum morphology J:211773
enlarged lymph nodes J:211773
Serpine1tm1.1Vlp/Serpine1tm1.1Vlp
involves: 129 * C57BL/6 		decreased susceptibility to endotoxin shock J:229191
decreased susceptibility to xenobiotic induced morbidity/mortality J:229191
Serpine1tm1Mlg/Serpine1tm1Mlg
B6.129S2-Serpine1tm1Mlg/J 		abnormal enzyme/coenzyme activity J:123733
cardiac fibrosis J:101486
heart inflammation J:101486
increased angiogenesis J:108675
increased susceptibility to bacterial infection J:124327
increased susceptibility to Coronaviridae infection J:288556
increased susceptibility to Coronaviridae infection induced morbidity/mortality J:288556
increased susceptibility to induced morbidity/mortality J:124327
liver fibrosis J:123733
normal liver/biliary system phenotype J:123733
lung hemorrhage J:288556
Serpine1tm1Mlg/Serpine1tm1Mlg
involves: 129S2/SvPas 		decreased susceptibility to endotoxin shock J:229191
decreased susceptibility to xenobiotic induced morbidity/mortality J:229191
Serpine1tm1Mlg/Serpine1tm1Mlg
involves: 129S2/SvPas * C57BL/6 		abnormal acute inflammation J:133227
abnormal blood circulation J:67531
abnormal body weight J:87982
abnormal energy expenditure J:87982
abnormal enzyme/coenzyme activity J:133227
abnormal epididymal fat pad morphology J:87982
abnormal interleukin level J:133227
abnormal lung morphology J:31542
decreased angiogenesis J:65383
decreased body weight J:133227
decreased circulating interleukin-6 level J:133227
decreased liver triglyceride level J:87982
decreased skeletal muscle triglyceride level J:87982
decreased subcutaneous adipose tissue amount J:87982
enhanced wound healing J:72394
glomerular crescent J:85989
glomerulonephritis J:85989
normal hematopoietic system phenotype J:39819
normal immune system phenotype J:133227
increased acute inflammation J:133227
increased body temperature J:87982
increased granulocyte number J:133227
increased oxygen consumption J:87982
increased urine protein level J:85989
normal neoplasm J:33232
respiratory system inflammation J:66093
weight loss J:133227
Serpine1tm1Mlg/Serpine1tm1Mlg
involves: 129S2/SvPas * C57BL/6 * C57BLKS/J 		abnormal kidney morphology J:127478
abnormal renal glomerulus morphology J:127478
decreased circulating cholesterol level J:127478
normal homeostasis/metabolism phenotype J:127478
hyperglycemia J:127478
increased blood urea nitrogen level J:127478
Tg(CMV-Serpine1)1Dgi/0
B6.Cg-Tg(CMV-Serpine1)1Dgi 		normal cardiovascular system phenotype J:61287
Tg(CMV-Serpine1)1Dgi/0
involves: C57BL/6J * SJL/J 		abnormal lung morphology J:31542
normal neoplasm J:33232
pulmonary fibrosis J:31542, J:140007
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory