Serpine1 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Serpine1
serine (or cysteine) peptidase inhibitor, clade E, member 1
MGI:97608

15 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Apoe^tm1Unc/Apoe^tm1Unc Serpine1^tm1Mlg/Serpine1^tm1Mlg B6.129-Serpine1^tm1Mlg Apoe^tm1Unc	atherosclerotic lesions	J:61287
	increased circulating cholesterol level	J:61287
Apoe^tm1Unc/Apoe^tm1Unc Tg(CMV-Serpine1)1Dgi/0 B6.Cg-Apoe^tm1Unc Tg(CMV-Serpine1)1Dgi	atherosclerotic lesions	J:61287
	increased circulating cholesterol level	J:61287
Ldlr^tm1Her/Ldlr^tm1Her Serpine1^tm1Mlg/Serpine1^tm1Mlg B6.129S-Serpine1^tm1Mlg Ldlr^tm1Her	atherosclerotic lesions	J:61287
	increased circulating cholesterol level	J:61287
Ldlr^tm1Her/Ldlr^tm1Her Tg(CMV-Serpine1)1Dgi/0 B6.Cg-Ldlr^tm1Her Tg(CMV-Serpine1)1Dgi	atherosclerotic lesions	J:61287
	increased circulating cholesterol level	J:61287
Lep^ob/Lep^ob Serpine1^tm1Mlg/Serpine1^tm1Mlg involves: 129S2/SvPas * C57BL/6	abnormal tumor necrosis factor level	J:70695
	impaired glucose tolerance	J:70695
	increased circulating insulin level	J:70695
Lepr^db/Lepr^db Serpine1^tm1Mlg/Serpine1^tm1Mlg involves: 129S2/SvPas * C57BL/6 * C57BLKS/J	abnormal enzyme/coenzyme activity	J:127478
	abnormal kidney morphology	J:127478
	abnormal renal glomerulus morphology	J:127478
	albuminuria	J:127478
	decreased body size	J:127478
	hyperglycemia	J:127478
	increased blood urea nitrogen level	J:127478
	obese	J:127478
	premature death	J:127478
Serpinb2^tm1Dgi/Serpinb2^tm1Dgi Serpine1^tm1Mlg/Serpine1^tm1Mlg involves: 129S1/Sv * 129S2/SvPas * C57BL/6 * DBA/2	normal homeostasis/metabolism phenotype	J:52283
Serpinb2^tm2Dgi/Serpinb2^tm2Dgi Serpine1^tm1Mlg/Serpine1^tm1Mlg involves: 129S2/SvPas * C57BL/6J * DBA/2J	normal homeostasis/metabolism phenotype	J:52283

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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