Plau Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Plau
plasminogen activator, urokinase
MGI:97611

80 phenotypes from 5 alleles in 9 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Plau^tm1.1Bug/Plau^tm1.1Bug involves: C57BL/6	chronic inflammation	J:164542
	decreased physiological sensitivity to xenobiotic	J:164542
	normal homeostasis/metabolism phenotype	J:164542
	liver fibrosis	J:164542
	liver inflammation	J:164542
	trachea inflammation	J:164542
Plau^{tm1b(EUCOMM)Wtsi}/Plau^{tm1b(EUCOMM)Wtsi} C57BL/6N-Plau^{tm1b(EUCOMM)Wtsi}/H	decreased exploration in new environment	J:211773
	decreased grip strength	J:211773
	increased monocyte cell number	J:211773
	increased neutrophil cell number	J:211773
Plau^tm1Mlg/Plau^tm1Mlg B6.129S2-Plau^tm1Mlg	abnormal response to injury	J:164542
	abnormal trachea morphology	J:164542
	cachexia	J:164542
	chronic inflammation	J:164542
	decreased liver glycogen level	J:164542
	decreased total body fat amount	J:164542
	increased inflammatory response	J:164542
	liver fibrosis	J:164542
	liver inflammation	J:164542
	premature death	J:164542
	trachea fibrosis	J:164542
	trachea inflammation	J:164542
Plau^tm1Mlg/Plau^tm1Mlg B6.Cg-Plau^tm1Mlg	abnormal acute phase protein level	J:68083
	abnormal cytokine level	J:75303
	abnormal perineum morphology	J:73613
	abnormal rectum morphology	J:73613
	abnormal tumor morphology	J:65383
	decreased inflammatory response	J:68083
	decreased metastatic potential	J:65383
	decreased susceptibility to induced arthritis	J:75303
	decreased T cell proliferation	J:75303
	decreased tumor growth/size	J:65383
	herniated seminal vesicle	J:73613
	impaired macrophage chemotaxis	J:68083
	impaired skeletal muscle regeneration	J:68083
	myopathy	J:73613
	rectal prolapse	J:73613
Plau^tm1Mlg/Plau^tm1Mlg either: B6.Cg-Plau^tm1Mlg or (involves: Black Swiss * C57BL/6)	reduced thrombolysis	J:64220
Plau^tm1Mlg/Plau^tm1Mlg involves: 129S2/SvPas * C57BL/6	abnormal acute phase protein level	J:63134, J:82604
	abnormal cell-mediated immunity	J:87817, J:95638
	abnormal circulating protein level	J:104962
	abnormal eyelid morphology	J:17427
	abnormal facial skin morphology	J:17427
	abnormal macrophage physiology	J:17427
	abnormal neutrophil physiology	J:75573, J:91980
	abnormal outer ear skin morphology	J:17427
	abnormal thrombosis	J:17427
	cardiac interstitial fibrosis	J:95236
	decreased response of heart to induced stress	J:95236
	decreased susceptibility to induced choroidal neovascularization	J:82604
	normal growth/size/body region phenotype	J:17427
	normal hematopoietic system phenotype	J:17427
	impaired granulocyte bactericidal activity	J:91980
	impaired macrophage chemotaxis	J:63134
	impaired neutrophil phagocytosis	J:91980
	increased heart left ventricle muscle contractility	J:95236
	increased lymphocyte cell number	J:63134
	increased susceptibility to fungal infection	J:95637
	increased susceptibility to induced thrombosis	J:17427
	increased susceptibility to parasitic infection	J:87817
	normal mortality/aging	J:17427
	normal nervous system phenotype	J:55243, J:104962
	pulmonary interstitial fibrosis	J:63134
	rectal prolapse	J:17427
	normal reproductive system phenotype	J:17427
Tg(MSR1-Plau)1Ddi/0 involves: C57BL/6 * SJL	cardiac fibrosis	J:101486
	enlarged heart	J:101486
	heart inflammation	J:101486
Tg(Mup3-Plau)350-2Eps/? C57BL/6-Tg(Mup3-Plau)350-2Eps	abnormal circulating alanine transaminase level	J:233146
	abnormal endoplasmic reticulum morphology	J:233146
	abnormal hepatocyte morphology	J:233146
	hepatic necrosis	J:233146
	hepatic steatosis	J:233146
	increased hepatocellular carcinoma incidence	J:233146
	increased hepatocyte apoptosis	J:233146
	increased interleukin-1 beta secretion	J:233146
	increased liver adenoma incidence	J:233146
	increased liver cholesterol level	J:233146
	increased liver free fatty acids level	J:233146
	increased liver triglyceride level	J:233146
	increased liver tumor incidence	J:233146
	increased tumor necrosis factor secretion	J:233146
	liver fibrosis	J:233146
	liver hyperplasia	J:233146
	liver inflammation	J:233146
Tg(Mup3-Plau)350-2Eps/0 involves: C57BL/6	normal cardiovascular system phenotype	J:66132
	increased circulating alanine transaminase level	J:66132
	increased liver tumor incidence	J:66132
	pale liver	J:66132
Tg(Mup3-Plau)350-2Eps/0 involves: C57BL/6 * FVB/N	subcutaneous edema	J:66132

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