Plau Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Plau
plasminogen activator, urokinase
MGI:97611

29 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Apoe^tm1Bres/Apoe^tm1Bres Plau^tm1Mlg/Plau^tm1Mlg involves: 129 * C57BL/6	aortic elastic tissue lesions	J:44387
	decreased susceptibility to atherosclerosis	J:44387
Apoe^tm1Unc/Apoe^tm1Unc Tg(MSR1-Plau)1Ddi/0 involves: 129P2/OlaHsd * C57BL/6 * SJL	abnormal artery morphology	J:102208
	abnormal heart morphology	J:101486
	artery occlusion	J:101486, J:102208
	enlarged heart	J:101486
	heart inflammation	J:101486
	increased susceptibility to atherosclerosis	J:102208
	increased susceptibility to induced morbidity/mortality	J:102208
Ddit3^tm1.1Irt/Ddit3^tm1.1Irt Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Tg(Mup3-Plau)350-2Eps/? involves: C57BL/6 * DBA	increased hepatocellular carcinoma incidence	J:233146
Plat^tm1Mlg/Plat^tm1Mlg Plau^tm1Mlg/Plau^tm1Mlg involves: 129S2/SvPas * C57BL/6	abnormal eyelid morphology	J:17427
	abnormal facial skin morphology	J:17427
	abnormal outer ear skin morphology	J:17427
	abnormal thrombosis	J:17427
	cachexia	J:17427
	cellular necrosis	J:17427
	decreased body size	J:17427
	decreased body weight	J:17427
	decreased litter size	J:17427
	postnatal growth retardation	J:17427
	premature death	J:17427
	rectal prolapse	J:17427
	reduced fertility	J:17427
	reduced thrombolysis	J:17427
	respiratory distress	J:17427
Plau^tm1Mlg/Plau^tm1Mlg Tg(RIP1-Tag)2Dh/0 involves: C57BL/6	normal cardiovascular system phenotype	J:65019
Plau^tm1Mlg/Plau^tm1Mlg Tg(RIP1-Tag)2Dh/0 involves: C57BL/6	increased carcinoma incidence	J:65019
Plau^tm1Mlg/Plau^tm1Mlg Thbd^tm2Rdr/Thbd^tm2Rdr involves: 129S2/SvPas	embryonic lethality	J:47676
Plaur^tm1Jld/Plaur^tm1Jld Tg(MSR1-Plau)1Ddi/0 B6.Cg-Plaur^tm1Jld Tg(MSR1-Plau)1Ddi	cardiac fibrosis	J:113474
	heart inflammation	J:113474
Plg^tm1Jld/Plg⁺ Tg(MSR1-Plau)1Ddi/0 B6.Cg-Plg^tm1Jld Tg(MSR1-Plau)1Ddi	abnormal heart morphology	J:113474

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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