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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Plcb1
phospholipase C, beta 1
MGI:97613
39 phenotypes from 3 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Plcb1em1(IMPC)Mbp/Plcb1+
C57BL/6N-Plcb1em1(IMPC)Mbp/MbpMmucd 		abnormal eye morphology J:211773
abnormal kidney morphology J:211773
abnormal liver morphology J:211773
abnormal lymph node morphology J:211773
abnormal ovary morphology J:211773
abnormal skin morphology J:211773
abnormal spleen morphology J:211773
abnormal vitreous body morphology J:211773
cataract J:211773
enlarged kidney J:211773
enlarged lymph nodes J:211773
enlarged spleen J:211773
hyperactivity J:211773
microphthalmia J:211773
Plcb1em1(IMPC)Mbp/Plcb1em1(IMPC)Mbp
C57BL/6N-Plcb1em1(IMPC)Mbp/MbpMmucd 		female infertility J:211773
male infertility J:211773
Plcb1Tg(LGB)56Mbal/Plcb1Tg(LGB)56Mbal
involves: C57BL/6 * CBA 		abnormal brain size J:93076
abnormal long bone morphology J:93076
decreased body length J:93076
decreased body weight J:93076
disproportionate dwarf J:93076
enlarged cranium J:93076
increased cranium width J:93076
increased kidney weight J:93076
increased testis weight J:93076
kyphosis J:93076
postnatal growth retardation J:93076
postnatal lethality J:93076
reduced female fertility J:93076
reduced male fertility J:93076
Plcb1tm1Hssh/Plcb1tm1Hssh
involves: 129 * C57BL/6J 		abnormal excitatory postsynaptic currents J:159855
Plcb1tm1Hssh/Plcb1tm1Hssh
involves: 129/Sv * C57BL/6 		abnormal spatial learning J:151070
decreased prepulse inhibition J:151070
decreased startle reflex J:151070
hyperactivity J:151070
Plcb1tm1Hssh/Plcb1tm1Hssh
Not Specified 		convulsive seizures J:43077
decreased body size J:43077
increased susceptibility to pharmacologically induced seizures J:43077
lethality at weaning, incomplete penetrance J:43077
loss of hippocampal neurons J:43077
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory