Plcd1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Plcd1
phospholipase C, delta 1
MGI:97614

23 phenotypes from 2 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Plcd1^tm1.1Kfu/Plcd1^tm1.1Kfu Tg(KRT14-cre)1Amc/0 involves: C57BL/6 * C57BL/6JJcl * CBA	decreased B cell number	J:205633
	decreased erythrocyte cell number	J:205633
	enlarged inguinal lymph nodes	J:205633
	increased circulating interleukin-17 level	J:205633
	increased granulocyte number	J:205633
	increased interleukin-17 secretion	J:205633
	increased NK T cell number	J:205633
	increased susceptibility to type IV hypersensitivity reaction	J:205633
Plcd1^tm1Tta/Plcd1^tm1Tta involves: 129P2/OlaHsd	abnormal common myeloid progenitor cell morphology	J:205633
	abnormal granulocyte differentiation	J:205633
	decreased B cell number	J:205633
	decreased erythrocyte cell number	J:205633
	enlarged axillary lymph nodes	J:205633
	enlarged inguinal lymph nodes	J:205633
	enlarged lymph nodes	J:205633
	enlarged spleen	J:205633
	normal hematopoietic system phenotype	J:205633
	increased circulating interleukin-17 level	J:205633
	increased granulocyte number	J:205633
	increased interleukin-17 secretion	J:205633
	increased leukocyte cell number	J:205633
Plcd1^tm1Tta/Plcd1^tm1Tta involves: 129P2/OlaHsd * C57BL/6J	abnormal epidermis suprabasal layer morphology	J:83948
	abnormal hair follicle morphology	J:83948
	abnormal keratinocyte differentiation	J:83948
	alopecia	J:83948
	decreased body size	J:83948
	epidermal cyst	J:83948
	increased sebocyte number	J:83948
	increased skin tumor incidence	J:83948

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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