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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Plcg1
phospholipase C, gamma 1
MGI:97615
20 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Plcg1tm1Gcrp/Plcg1tm1Rwen
Tg(Cd4-cre)1Cwi/0
involves: 129X1/SvJ * C57BL/6 * DBA/2 		abnormal CD4-positive T cell differentiation J:157757
abnormal CD8-positive, alpha-beta T cell differentiation J:157757
abnormal regulatory T cell physiology J:157757
abnormal T cell activation J:157757
alopecia J:157757
decreased body weight J:157757
decreased CD4-positive, alpha-beta T cell number J:157757
decreased CD8-positive, alpha-beta T cell number J:157757
decreased interferon-gamma secretion J:157757
decreased interleukin-2 secretion J:157757
decreased single-positive T cell number J:157757
decreased T cell number J:157757
decreased T cell proliferation J:157757
dermatitis J:157757
increased double-positive T cell number J:157757
increased T cell apoptosis J:157757
rectal prolapse J:157757
Plcg1tm1Gcrp/Plcg1tm1Rwen
Tg(Cd4-cre)1Cwi/0
Tg(TcraH-Y,TcrbH-Y)71Vbo/0
involves: 129X1/SvJ * C57BL/6 * DBA/2 		decreased CD8-positive, alpha-beta T cell number J:157757
decreased double-negative T cell number J:157757
increased CD8-positive, alpha-beta T cell number J:157757
increased double-positive T cell number J:157757
thymus hyperplasia J:157757
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory