Plcg2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Plcg2
phospholipase C, gamma 2
MGI:97616

52 phenotypes from 12 alleles in 15 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Plcg2^al/Plcg2^al involves: 129 * C57BL/6	abnormal lymphatic vessel morphology	J:143529
	chylous ascites	J:143529
	internal hemorrhage	J:143529
	premature death	J:143529
Plcg2^Ali5/Plcg2⁺ C3HeB/FeJ-Plcg2^Ali5	abnormal B cell physiology	J:97930
	chronic inflammation	J:97930
	decreased B-2 B cell number	J:97930
	dermatitis	J:97930
	osteoarthritis	J:97930
Plcg2^Ali5/Plcg2⁺ involves: C57BL/6J * C3HeB/FeJ-Plcg2^Ali5	abnormal B cell physiology	J:97930
	glomerulonephritis	J:97930
	normal immune system phenotype	J:97930
Plcg2^Ali5/Plcg2^Ali5 involves: C57BL/6J * C3HeB/FeJ-Plcg2^Ali5	abnormal B cell physiology	J:97930
	chronic inflammation	J:97930
	decreased mature B cell number	J:97930
	decreased transitional stage B cell number	J:97930
	glomerulonephritis	J:97930
Plcg2^Ali14/Plcg2⁺ C3HeB/FeJ-Plcg2^Ali14	abnormal foot pad morphology	J:166106
Plcg2^Ali14/Plcg2⁺ C3HeB/FeJ-Plcg2^Ali14	abnormal inflammatory response	J:166106
Plcg2^em1Msasn/Plcg2^em1Msasn B6.Cg-Plcg2^em1Msasn/J	abnormal calcium level	J:308279
	abnormal endocytosis	J:308279
	impaired macrophage phagocytosis	J:308279
Plcg2^m1Btlr/Plcg2^m1Btlr C57BL/6J-Plcg2^m1Btlr	decreased IgM level	J:165702
Plcg2^m1Btlr/Plcg2^m1Btlr involves: C57BL/6J	abnormal B cell differentiation	J:185495
	decreased IgM level	J:185495
	normal immune system phenotype	J:185495
Plcg2^M2Btlr/Plcg2⁺ C57BL/6J-Plcg2^M2Btlr	decreased tumor necrosis factor secretion	J:218966
Plcg2^M2Btlr/Plcg2^M2Btlr C57BL/6J-Plcg2^M2Btlr	decreased tumor necrosis factor secretion	J:218966
Plcg2^M3Btlr/Plcg2^M3Btlr C57BL/6J-Plcg2^M3Btlr	abnormal humoral immune response	J:265101
	decreased B-1a cell number	J:265101
	decreased IgM level	J:265101
Plcg2^m4Btlr/Plcg2^m4Btlr C57BL/6J-Plcg2^m4Btlr	decreased CD8-positive, naive alpha-beta T cell number	J:272862
Plcg2^m4Btlr/Plcg2^m4Btlr C57BL/6J-Plcg2^m4Btlr	increased effector memory CD8-positive, alpha-beta T cell number	J:272862
Plcg2^tm1.1Kuro/Plcg2^tm1.1Kuro B6.Cg-Plcg2^tm1.1Kuro	decreased interferon-gamma secretion	J:131621
Plcg2^tm1.1Kuro/Plcg2^tm1.1Kuro B6.Cg-Plcg2^tm1.1Kuro	impaired natural killer cell mediated cytotoxicity	J:131621
Plcg2^tm1.1Kuro/Plcg2^tm1.1Kuro Not Specified	abnormal B cell differentiation	J:131161
	abnormal NK cell physiology	J:187430
	increased pro-B cell number	J:131161
	spleen hyperplasia	J:131161
Plcg2^tm1Ichi/Plcg2^tm1Ichi involves: 129 * C57BL/6	abnormal lymphatic vessel morphology	J:143529
	chylous ascites	J:143529
	internal hemorrhage	J:143529
	premature death	J:143529
Plcg2^tm1Jni/Plcg2^tm1Jni involves: 129P2/OlaHsd	abnormal B cell calcium ion homeostasis	J:80614
	abnormal dendritic cell chemotaxis	J:157619
	abnormal dendritic cell morphology	J:157619
	abnormal dendritic cell physiology	J:157619
	arrested B cell differentiation	J:86373
	decreased B cell proliferation	J:80614
	decreased follicular B cell number	J:86373
	decreased mature B cell number	J:104166
	decreased platelet aggregation	J:114266
	decreased susceptibility to induced arthritis	J:157619
	increased B cell apoptosis	J:86373
	increased pro-B cell number	J:104166
	increased transitional stage T2 B cell number	J:86373
Plcg2^tm1Jni/Plcg2^tm1Jni involves: 129P2/OlaHsd * C57BL/6	abnormal B cell differentiation	J:117023
	abnormal B cell physiology	J:117023
	abnormal osteoclast differentiation	J:114607
	abnormal trabecular bone morphology	J:114607
	decreased interferon-gamma secretion	J:100716
	decreased osteoclast cell number	J:114607
	impaired natural killer cell mediated cytotoxicity	J:100716
	increased B cell proliferation	J:117023
	increased pre-B cell number	J:117023
	increased susceptibility to Herpesvirales infection	J:100716
	increased trabecular bone thickness	J:114607
	increased trabecular bone volume	J:114607
Plcg2^tm1Kuro/Plcg2^tm1Kuro Tg(Mx1-cre)1Cgn/0 involves: C57BL/6 * CBA	abnormal humoral immune response	J:63744
	decreased B cell proliferation	J:63744
	decreased mature B cell number	J:63744
	decreased pre-B cell number	J:63744
	normal immune system phenotype	J:63744
	increased B-1a cell number	J:63744
	increased immature B cell number	J:63744
	increased pro-B cell number	J:63744

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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