Plcg2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Plcg2
phospholipase C, gamma 2
MGI:97616

52 phenotypes from 12 alleles in 15 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Plcg2^al/Plcg2^al involves: 129 * C57BL/6	abnormal lymphatic vessel morphology	J:143529
	chylous ascites	J:143529
	internal hemorrhage	J:143529
	premature death	J:143529
Plcg2^Ali5/Plcg2⁺ C3HeB/FeJ-Plcg2^Ali5	abnormal B cell physiology	J:97930
	chronic inflammation	J:97930
	decreased B-2 B cell number	J:97930
	dermatitis	J:97930
	osteoarthritis	J:97930
Plcg2^Ali5/Plcg2⁺ involves: C57BL/6J * C3HeB/FeJ-Plcg2^Ali5	abnormal B cell physiology	J:97930
	glomerulonephritis	J:97930
	normal immune system phenotype	J:97930
Plcg2^Ali5/Plcg2^Ali5 involves: C57BL/6J * C3HeB/FeJ-Plcg2^Ali5	abnormal B cell physiology	J:97930
	chronic inflammation	J:97930
	decreased mature B cell number	J:97930
	decreased transitional stage B cell number	J:97930
	glomerulonephritis	J:97930
Plcg2^Ali14/Plcg2⁺ C3HeB/FeJ-Plcg2^Ali14	abnormal foot pad morphology	J:166106
Plcg2^Ali14/Plcg2⁺ C3HeB/FeJ-Plcg2^Ali14	abnormal inflammatory response	J:166106
Plcg2^em1Msasn/Plcg2^em1Msasn B6.Cg-Plcg2^em1Msasn/J	abnormal calcium level	J:308279
	abnormal endocytosis	J:308279
	impaired macrophage phagocytosis	J:308279
Plcg2^m1Btlr/Plcg2^m1Btlr C57BL/6J-Plcg2^m1Btlr	decreased IgM level	J:165702
Plcg2^m1Btlr/Plcg2^m1Btlr involves: C57BL/6J	abnormal B cell differentiation	J:185495
	decreased IgM level	J:185495
	normal immune system phenotype	J:185495
Plcg2^M2Btlr/Plcg2⁺ C57BL/6J-Plcg2^M2Btlr	decreased tumor necrosis factor secretion	J:218966
Plcg2^M2Btlr/Plcg2^M2Btlr C57BL/6J-Plcg2^M2Btlr	decreased tumor necrosis factor secretion	J:218966
Plcg2^M3Btlr/Plcg2^M3Btlr C57BL/6J-Plcg2^M3Btlr	abnormal humoral immune response	J:265101
	decreased B-1a cell number	J:265101
	decreased IgM level	J:265101
Plcg2^m4Btlr/Plcg2^m4Btlr C57BL/6J-Plcg2^m4Btlr	decreased CD8-positive, naive alpha-beta T cell number	J:272862
Plcg2^m4Btlr/Plcg2^m4Btlr C57BL/6J-Plcg2^m4Btlr	increased effector memory CD8-positive, alpha-beta T cell number	J:272862
Plcg2^tm1.1Kuro/Plcg2^tm1.1Kuro B6.Cg-Plcg2^tm1.1Kuro	decreased interferon-gamma secretion	J:131621
Plcg2^tm1.1Kuro/Plcg2^tm1.1Kuro B6.Cg-Plcg2^tm1.1Kuro	impaired natural killer cell mediated cytotoxicity	J:131621
Plcg2^tm1.1Kuro/Plcg2^tm1.1Kuro Not Specified	abnormal B cell differentiation	J:131161
	abnormal NK cell physiology	J:187430
	increased pro-B cell number	J:131161
	spleen hyperplasia	J:131161
Plcg2^tm1Ichi/Plcg2^tm1Ichi involves: 129 * C57BL/6	abnormal lymphatic vessel morphology	J:143529
	chylous ascites	J:143529
	internal hemorrhage	J:143529
	premature death	J:143529
Plcg2^tm1Jni/Plcg2^tm1Jni involves: 129P2/OlaHsd	abnormal B cell calcium ion homeostasis	J:80614
	abnormal dendritic cell chemotaxis	J:157619
	abnormal dendritic cell morphology	J:157619
	abnormal dendritic cell physiology	J:157619
	arrested B cell differentiation	J:86373
	decreased B cell proliferation	J:80614
	decreased follicular B cell number	J:86373
	decreased mature B cell number	J:104166
	decreased platelet aggregation	J:114266
	decreased susceptibility to induced arthritis	J:157619
	increased B cell apoptosis	J:86373
	increased pro-B cell number	J:104166
	increased transitional stage T2 B cell number	J:86373
Plcg2^tm1Jni/Plcg2^tm1Jni involves: 129P2/OlaHsd * C57BL/6	abnormal B cell differentiation	J:117023
	abnormal B cell physiology	J:117023
	abnormal osteoclast differentiation	J:114607
	abnormal trabecular bone morphology	J:114607
	decreased interferon-gamma secretion	J:100716
	decreased osteoclast cell number	J:114607
	impaired natural killer cell mediated cytotoxicity	J:100716
	increased B cell proliferation	J:117023
	increased pre-B cell number	J:117023
	increased susceptibility to Herpesvirales infection	J:100716
	increased trabecular bone thickness	J:114607
	increased trabecular bone volume	J:114607
Plcg2^tm1Kuro/Plcg2^tm1Kuro Tg(Mx1-cre)1Cgn/0 involves: C57BL/6 * CBA	abnormal humoral immune response	J:63744
	decreased B cell proliferation	J:63744
	decreased mature B cell number	J:63744
	decreased pre-B cell number	J:63744
	normal immune system phenotype	J:63744
	increased B-1a cell number	J:63744
	increased immature B cell number	J:63744
	increased pro-B cell number	J:63744

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24