Plcg2 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Plcg2
phospholipase C, gamma 2
MGI:97616

22 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Blnk^tm1Kplm/Blnk^tm1Kplm Plcg2^tm1.1Kuro/Plcg2⁺ involves: 129P2/OlaHsd	abnormal B cell activation	J:131161
	decreased B cell number	J:131161
	increased B cell apoptosis	J:131161
Blnk^tm1Kplm/Blnk^tm1Kplm Plcg2^tm1.1Kuro/Plcg2^tm1.1Kuro involves: 129P2/OlaHsd	decreased B cell number	J:131161
	increased B cell apoptosis	J:131161
	perinatal lethality, incomplete penetrance	J:131161
	spleen hypoplasia	J:131161
Igh^tm1.1Twin/Igh^tm1.1Twin Plcg2^Ali5/Plcg2⁺ involves: 129 * 129S4/SvJae * C3HeB/FeJ * C57BL/6	normal immune system phenotype	J:174233
	increased B-1a cell number	J:174233
Pik3r1^tm1Dfr/Pik3r1^tm1Dfr Plcg2^tm1Jni/Plcg2^tm1Jni involves: 129P2/OlaHsd * 129S6/SvEvTac	abnormal B cell differentiation	J:104166
	arrested B cell differentiation	J:104166
	decreased body size	J:104166
	decreased immature B cell number	J:104166
	decreased mature B cell number	J:104166
	decreased pre-B cell number	J:104166
	normal hematopoietic system phenotype	J:104166
	normal immune system phenotype	J:104166
	increased B cell apoptosis	J:104166
	lethality throughout fetal growth and development, complete penetrance	J:104166
Plcg2^Ali5/Plcg2⁺ Rag1^tm1Mom/Rag1^tm1Mom involves: 129S7/SvEvBrd * C3HeB/FeJ * C3HeB/FeJ-Plcg2^Ali5	chronic inflammation	J:97930
	dermatitis	J:97930
	osteoarthritis	J:97930
Plcg2^tm1Jni/Plcg2^tm1Jni Tg(IghMyc)22Bri/0 involves: 129P2/OlaHsd * C57BL * C57BL/6 * SJL	enlarged lymph nodes	J:117023
	increased B cell derived lymphoma incidence	J:117023
	increased lymphoma incidence	J:117023
	premature death	J:117023

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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