Plk1 Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Plk1
polo like kinase 1
MGI:97621

13 phenotypes from 2 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Plk1^{Gt(RRR358)Byg}/Plk1⁺ involves: 129P2/OlaHsd * C57BL/6	aneuploidy	J:142593
	increased lung carcinoma incidence	J:142593
	increased lymphoma incidence	J:142593
	increased sarcoma incidence	J:142593
	increased squamous cell carcinoma incidence	J:142593
	increased tumor incidence	J:142593
Plk1^{Gt(RRR358)Byg}/Plk1^{Gt(RRR358)Byg} involves: 129P2/OlaHsd * C57BL/6	abnormal cell cycle	J:142593
	abnormal mitotic spindle morphology	J:142593
	embryonic growth arrest	J:142593
	embryonic lethality before implantation, complete penetrance	J:142593
Plk1^{tm1b(EUCOMM)Hmgu}/Plk1^{tm1b(EUCOMM)Hmgu} C57BL/6N-Plk1^{tm1b(EUCOMM)Hmgu}/Tcp	embryonic lethality prior to organogenesis	J:211773
	embryonic lethality prior to tooth bud stage	J:211773
	preweaning lethality, complete penetrance	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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