Pln Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pln
phospholamban
MGI:97622

24 phenotypes from 6 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Pln^tm1Egk/Pln^tm1Egk involves: 129S2/SvPas	abnormal cardiac muscle relaxation	J:106044
	abnormal myocardial fiber physiology	J:106044
	atrial fibrillation	J:212640
	increased cardiac muscle contractility	J:106044
Pln^tm1Egk/Pln^tm1Egk involves: 129S2/SvPas * CF-1	abnormal heart left ventricle pressure	J:39745
Pln^tm1Egk/Pln^tm1Egk involves: 129S2/SvPas * CF-1	increased cardiac muscle contractility	J:39745, J:59967
Pln^tm1Egk/Pln^tm1Egk involves: 129S2/SvPas * CF-1 * FVB/N	increased heart weight	J:134706
Pln^tm1Egk/Pln^tm1Egk Tg(Myh6-Pln)1Egk/? involves: 129S2/SvPas	normal cardiovascular system phenotype	J:66084
Pln^tm1Egk/Pln^tm1Egk Tg(Myh6-Pln)11Egk/? involves: 129S2/SvPas	abnormal cardiac muscle contractility	J:66084
	abnormal myocardial fiber physiology	J:66084
Pln^tm1Egk/Pln^tm1Egk Tg(Myh6-Pln)22Egk/? involves: 129S2/SvPas	normal cardiovascular system phenotype	J:66084
Tg(Myh6-Pln)416Egk/? FVB/N-Tg(Myh6-Pln)416Egk	abnormal cardiac muscle contractility	J:135899
Tg(Myh6-Pln)416Egk/? FVB/N-Tg(Myh6-Pln)416Egk	abnormal myocardial fiber physiology	J:135899
Tg(Myh7-Pln)2Egk/0 FVB/N-Tg(Myh7-Pln)2Egk	abnormal muscle physiology	J:224766
	abnormal skeletal muscle fiber morphology	J:224766
	abnormal skeletal muscle fiber type ratio	J:224766
	centrally nucleated skeletal muscle fibers	J:224766
	decreased soleus weight	J:224766
	impaired exercise endurance	J:224766
	impaired skeletal muscle contractility	J:94077
	increased creatine kinase activity	J:224766
	muscle weakness	J:224766
	myopathy	J:224766
	oxidative stress	J:224766
	skeletal muscle atrophy	J:94077, J:224766
	skeletal muscle endomysial fibrosis	J:224766
	skeletal muscle fibrosis	J:224766
Tg(Myh7-Pln)2Egk/? involves: FVB/N	abnormal skeletal muscle fiber type ratio	J:127873
	abnormal soleus morphology	J:127873
	impaired muscle relaxation	J:127873
	impaired skeletal muscle contractility	J:127873

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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