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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Plp1
proteolipid protein (myelin) 1
MGI:97623
66 phenotypes from 16 alleles in 29 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Plp1jp-4J/Y
involves: C3H/HeJ * C57BL/6J 		abnormal CNS glial cell morphology J:36181
astrocytosis J:36181
decreased oligodendrocyte number J:41569
demyelination J:36181, J:41569
lethality at weaning, complete penetrance J:41569
seizures J:41569
tremors J:41569
Plp1jp-6J/Y
BALB/cJ-Plp1jp-6J/GrsrJ 		asthenozoospermia J:236909
oligozoospermia J:236909
premature death J:236909
tremors J:236909
Plp1jp-msd/Y
B6C3-EdaTa Plp1jp-msd 		decreased body weight J:7157
demyelination J:7157
tremors J:7157
Plp1jp-msd/Y
involves: BALB/c * C3H * C57BL/6 * C57BL/10 		increased apoptosis J:121540
premature death J:121540
Plp1jp-msd/Y
involves: BALB/c * C57BL/6J * C57BL/10 		abnormal myelination J:159450
premature death J:159450
Plp1jp-msd/Y
involves: C57BL/10Sn * BALB/cJ 		abnormal myelination J:5170
demyelination J:5170
postnatal lethality, complete penetrance J:5170
seizures J:5170
tremors J:5170
Plp1jp-msd/Plp1jp-msd
involves: BALB/c * C57BL/6J * C57BL/10 		abnormal myelination J:159450
premature death J:159450
Plp1jp-rsh/Y
C3H * C57BL/6 * STOCK Rb(1.3)1Bnr 		abnormal myelin sheath morphology J:31089
demyelination J:31089
Plp1jp-rsh/Plp1+
either: STOCK Rb(1.3)1Bnr or (involves: BALB/c * DBA/2 * STOCK Rb(1.3)1Bnr) 		abnormal microglial cell morphology J:604
abnormal myelination J:604
abnormal oligodendrocyte morphology J:604
demyelination J:604
increased oligodendrocyte number J:604
Plp1jp-rsh/Y
involves: 101 * C3H 		abnormal astrocyte morphology J:10575
abnormal axonal transport J:229229
abnormal brain development J:88023
abnormal glial cell morphology J:88023
astrocytosis J:88023
normal behavior/neurological phenotype J:14143
demyelination J:10575, J:14143, J:88023
dysmyelination J:229229
normal growth/size/body region phenotype J:14143
impaired coordination J:88023
increased oligodendrocyte number J:10575
normal reproductive system phenotype J:14143
tremors J:10575, J:14143, J:88023
Plp1jp-rsh/Y
involves: C3H * C57BL/6 * STOCK Rb(1.3)1Bnr 		abnormal locomotor coordination J:121540
increased apoptosis J:121540
Plp1jp-rsh/Y
involves: C57BL/6NCrl 		abnormal brain development J:88023
abnormal glial cell morphology J:88023
astrocytosis J:88023
decreased body weight J:88023
decreased locomotor activity J:88023
demyelination J:88023
impaired coordination J:88023
premature death J:88023
seizures J:88023
tremors J:88023
Plp1jp-rsh/Plp1jp-rsh
C3H * C57BL/6 * STOCK Rb(1.3)1Bnr 		abnormal myelin sheath morphology J:31089
abnormal phospholipid level J:31089
Plp1jp-rsh/Plp1jp-rsh
involves: 101 * C3H 		abnormal astrocyte morphology J:10575
normal behavior/neurological phenotype J:14143
demyelination J:10575, J:14143
normal growth/size/body region phenotype J:14143
increased oligodendrocyte number J:10575
normal reproductive system phenotype J:14143
tremors J:10575, J:14143
Plp1jp-rsh/Plp1jp-rsh
involves: 101/H * C3H 		decreased susceptibility to Picornaviridae infection J:41447
Plp1jp/Y
B6C3-EdaTa Plp1jp 		abnormal myelination J:7157
decreased body weight J:7157
demyelination J:7157
premature death J:7157
tremors J:7157
Plp1jp/Y
B6CB-Aw-J/A EdaTa Plp1jp 		abnormal astrocyte physiology J:116364
abnormal myelination J:5611, J:160743
abnormal oligodendrocyte morphology J:5611
abnormal startle reflex J:18363
decreased body weight J:18363
decreased locomotor activity J:18363
decreased oligodendrocyte number J:5611
decreased vocalization J:18363
delayed eyelid opening J:18363
Plp1jp/Plp1+
B6CB-Aw-J/A EdaTa Plp1jp 		astrocytosis J:6895
Plp1jp/Y
Not Specified 		abnormal astrocyte morphology J:159601
abnormal brain morphology J:13141
abnormal brain white matter morphology J:13141
abnormal myelin sheath morphology J:159601
abnormal myelination J:13141
abnormal oligodendrocyte morphology J:159601
environmentally induced seizures J:288
hindlimb paralysis J:13141
paraparesis J:13141
premature death J:288, J:13141
tonic-clonic seizures J:13141
tremors J:288, J:13141
Plp1tm1.1Blyg/Y
involves: 129S6/SvEvTac * C57BL/6J * FVB/N 		normal nervous system phenotype J:193537
Plp1tm1.1Gow/Y
Not Specified 		abnormal cerebellar granule layer morphology J:62287
abnormal cerebellum morphology J:62287
abnormal cerebellum white matter morphology J:62287
abnormal myelination J:62287
axon degeneration J:62287
axonal spheroids J:62287
demyelination J:62287
gliosis J:62287
impaired coordination J:62287
neurodegeneration J:62287
Plp1tm1c(EUCOMM)Wtsi/Y
Cnptm1(cre)Kan/Cnp+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N 		abnormal hippocampal fimbria morphology J:245100
astrocytosis J:245100
axonal spheroids J:245100
increased T cell number J:245100
microgliosis J:245100
Plp1tm1c(EUCOMM)Wtsi/Y
Neurod6tm1(cre)Kan/Neurod6+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N 		normal nervous system phenotype J:245100
Plp1tm1Frca/Y
B6.129-Plp1tm1Frca 		abnormal myelin sheath morphology J:143305
axon degeneration J:143305
normal behavior/neurological phenotype J:143305
demyelination J:143305
impaired coordination J:143305
Plp1tm1Gow/Y
Not Specified 		abnormal cerebellum white matter morphology J:62287
abnormal myelination J:62287
axon degeneration J:62287
axonal spheroids J:62287
demyelination J:62287
gliosis J:62287
impaired coordination J:62287
neurodegeneration J:62287
Plp1tm1Kan/Y
B6.129-Plp1tm1Kan 		astrocytosis J:201143
axon degeneration J:201143
axonal spheroids J:201143
decreased body weight J:201143
demyelination J:201143
hindlimb paralysis J:201143
kyphosis J:201143
microgliosis J:201143
Plp1tm1Kan/Y
B6N.129-Plp1tm1Kan 		axonal spheroids J:236408
dysmyelination J:236408
tomacula J:236408
Plp1tm1Kan/Y
involves: 129S1/Sv * 129X1/SvJ 		abnormal axon morphology J:48031
abnormal gait J:48031
abnormal hippocampal fimbria morphology J:245100
abnormal locomotor coordination J:48031
abnormal microglial cell morphology J:48031
abnormal myelin sheath morphology J:48031, J:193310
abnormal oligodendrocyte morphology J:48031, J:106182
astrocytosis J:48031, J:245100
axonal spheroids J:245100
decreased cholesterol level J:193310
demyelination J:48031
impaired coordination J:48031
microgliosis J:245100
Plp1tm1Kan/Plp1+
involves: 129S1/Sv * 129X1/SvJ 		abnormal axon morphology J:48031
Plp1tm1Kan/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal axon morphology J:146665
abnormal myelin sheath morphology J:146665
ataxia J:146665
axon degeneration J:146665
paraparesis J:146665
Plp1tm1Kan/Y
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal myelin sheath morphology J:38856
axonal spheroids J:38856
normal behavior/neurological phenotype J:38856
Plp1tm1Wst/Plp1+
involves: 129P2/OlaHsd 		abnormal oligodendrocyte morphology J:21976
Plp1tm1Wst/Plp1tm1Wst
involves: 129P2/OlaHsd 		abnormal axon morphology J:105188
abnormal myelin sheath morphology J:105188
abnormal myelination J:21976, J:105188
abnormal nerve conduction J:21976
abnormal oligodendrocyte morphology J:21976
axonal spheroids J:105188
decreased locomotor activity J:21976
impaired coordination J:21976
Plp1tm2Wst/Plp1+
involves: 129P2/OlaHsd 		abnormal oligodendrocyte morphology J:21976
Plp1tm2Wst/Plp1tm2Wst
involves: 129P2/OlaHsd 		abnormal myelination J:21976
abnormal nerve conduction J:21976
abnormal oligodendrocyte morphology J:21976
decreased locomotor activity J:21976
impaired coordination J:21976
Plp1tm3Wst/Plp1tm3Wst
B6.129S1-Plp1tm3Wst 		abnormal myelin sheath morphology J:105188
abnormal myelination J:105188
abnormal optic nerve morphology J:105188
Tg(Plp)66Kan/0
B6NCrl.Cg-Tg(Plp)66Kan 		abnormal myelin sheath morphology J:156106
ataxia J:156106
axon degeneration J:156106
demyelination J:156106
kyphosis J:156106
weight loss J:156106
Tg(Plp)66Kan/Tg(Plp)66Kan
B6NCrl.Cg-Tg(Plp)66Kan 		abnormal myelin sheath morphology J:156106
abnormal oligodendrocyte apoptosis J:156106
abnormal oligodendrocyte morphology J:156106
demyelination J:156106
premature death J:156106
seizures J:156106
tremors J:156106
Tg(Plp)66Kan/Tg(Plp)66Kan
involves: C57BL * DBA 		astrocytosis J:17373
ataxia J:17373
demyelination J:17373
premature death J:17373
seizures J:17373
tremors J:17373
Tg(Plp)72Kan/Tg(Plp)72Kan
B6N.Cg-Tg(Plp)72Kan 		abnormal axonal transport J:229229
abnormal cell cytoskeleton morphology J:229229
abnormal optic nerve morphology J:229229
abnormal optic tract morphology J:229229
decreased myelin sheath thickness J:229229
decreased nerve conduction velocity J:229229
demyelination J:229229
dysmyelination J:229229
Tg(Plp)72Kan/Tg(Plp)72Kan
involves: C57BL/6 * DBA 		astrocytosis J:17373
dysmyelination J:17373
premature death J:17373
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory