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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Plp1
proteolipid protein (myelin) 1
MGI:97623
41 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Casp12tm1Yuan/Casp12tm1Yuan
Plp1jp-msd/Y
involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/10 * BALB/c 		increased apoptosis J:121540
premature death J:121540
Casp12tm1Yuan/Casp12tm1Yuan
Plp1jp-rsh/Y
involves: 129S4/SvJae * C3H * C57BL/6 * STOCK Rb(1.3)1Bnr 		abnormal locomotor coordination J:121540
increased apoptosis J:121540
Gpm6btm1Kan/Gpm6b+
Plp1tm1Kan/Plp1tm1Kan
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal motor capabilities/coordination/movement J:193310
premature death J:193310
Gpm6btm1Kan/Gpm6btm1Kan
Plp1tm1Kan/Plp1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal motor capabilities/coordination/movement J:193310
premature death J:193310
Gpm6btm1KanPlp1tm1Kan/Y
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal auditory brainstem response waveform shape J:193310
abnormal brain white matter morphology J:193310
abnormal glial cell morphology J:193310
abnormal motor coordination/balance J:193310
abnormal myelin sheath morphology J:193310
abnormal myelination J:193310
abnormal oligodendrocyte apoptosis J:193310
abnormal oligodendrocyte morphology J:193310
abnormal stationary movement J:193310
absent visual evoked potential J:193310
astrocytosis J:193310
ataxia J:193310
axon degeneration J:193310
decreased anterior commissure size J:193310
decreased cholesterol level J:193310
decreased corpus callosum size J:193310
demyelination J:193310
enlarged brain ventricles J:193310
normal hearing/vestibular/ear phenotype J:193310
hunched posture J:193310
impaired hearing J:193310
increased apoptosis J:193310
microgliosis J:193310
muscle hypertonia J:193310
muscle spasm J:193310
neuron degeneration J:193310
premature death J:193310
retina degeneration J:193310
tremors J:193310
Mbpshi/Mbpshi
Plp1tm1Kan/Y
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SWV 		abnormal myelin sheath morphology J:38856
abnormal myelination J:38856
ataxia J:38856
normal mortality/aging J:38856
tremors J:38856
Mbpshi/Mbpshi
Plp1tm1Kan/Y
involves: 129S1/Sv * 129X1/SvJ * SWV 		axonal spheroids J:48031
demyelination J:48031
Plp1tm1Kan/Y
Cnptm1(cre)Kan/Cnp+
involves: 129S1/Sv * 129X1/SvJ 		abnormal hippocampal fimbria morphology J:245100
astrocytosis J:245100
axonal spheroids J:245100
increased T cell number J:245100
microgliosis J:245100
Plp1tm1Kan/Y
Tspan2tm1Hbw/Tspan2tm1Hbw
B6.Cg-Tspan2tm1Hbw Plp1tm1Kan 		astrocytosis J:201143
axon degeneration J:201143
axonal spheroids J:201143
brain inflammation J:201143
decreased body weight J:201143
demyelination J:201143
hindlimb paralysis J:201143
kyphosis J:201143
microgliosis J:201143
Tg(Plp)66Kan/0
Tg(Plp)72Kan/0
involves: C57BL/6 * DBA 		astrocytosis J:17373
convulsive seizures J:17373
dysmyelination J:17373
premature death J:17373
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory