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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Pmp22
peripheral myelin protein 22
MGI:97631
53 phenotypes from 14 alleles in 15 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Pmp22M1247Lja/Pmp22+
involves: C57BL/6J * DBA 		tremors J:179895
Pmp22Mhdatre002/Pmp22Mhdatre002
C3HeB/FeJ-Pmp22Mhdatre002 		increased circulating alkaline phosphatase level J:183993
tremors J:183993
Pmp22tm1Lnot/Pmp22+
Not Specified 		abnormal motor capabilities/coordination/movement J:104989
abnormal myelin sheath morphology J:104989
Pmp22tm1Lnot/Pmp22tm1Lnot
Not Specified 		abnormal axon morphology J:104989
abnormal gait J:104989
abnormal myelin sheath morphology J:104989
abnormal neuron morphology J:104989
abnormal Schwann cell morphology J:104989
abnormal sexual interaction J:104989
demyelination J:104989
hindlimb paralysis J:104989
limb grasping J:104989
muscle weakness J:104989
postnatal growth retardation J:104989
tremors J:104989
Pmp22tm1Ueli/Pmp22+
involves: 129S/SvEv 		abnormal axon morphology J:29517
abnormal motor coordination/balance J:29517
abnormal myelin sheath morphology J:29517
abnormal myelination J:29517
Pmp22tm1Ueli/Pmp22tm1Ueli
involves: 129S/SvEv 		abnormal action potential J:29517
abnormal axon morphology J:29517
abnormal myelin sheath morphology J:29517
abnormal myelination J:29517
convulsive seizures J:29517
decreased nerve conduction velocity J:29517
hindlimb paralysis J:29517
tremors J:29517
Pmp22tm1Ueli/Pmp22tm1Ueli
involves: 129S/SvEv * C57BL/6 		abnormal myelination J:98118
abnormal Schwann cell morphology J:98118
abnormal Schwann cell physiology J:98118
increased Schwann cell proliferation J:98118
Pmp22Tr-1H/Pmp22+
involves: BALB/cAnNCrl * C3H/HeN 		abnormal gait J:79382
abnormal motor coordination/balance J:79382
abnormal Schwann cell morphology J:79382
axon degeneration J:79382
decreased grip strength J:79382
decreased locomotor activity J:79382
demyelination J:63816, J:79382
impaired righting response J:79382
tremors J:79382
Pmp22Tr-2H/Pmp22+
involves: BALB/cAnNCrl * C3H/HeN 		abnormal gait J:79382
abnormal motor coordination/balance J:79382
abnormal Schwann cell morphology J:79382
axon degeneration J:79382
decreased grip strength J:79382
decreased locomotor activity J:79382
demyelination J:63816, J:79382
impaired righting response J:79382
tremors J:79382
Pmp22Tr-2J/Pmp22+
C57BL/6J-Pmp22Tr-2J/GrsrJ 		abnormal gait J:201866
ataxia J:201866
deafness J:201866
demyelination J:201866
impaired hearing J:201866
increased or absent threshold for auditory brainstem response J:201866
normal limbs/digits/tail phenotype J:201866
normal mortality/aging J:201866
reduced male fertility J:201866
spasticity J:201866
tremors J:201866
normal vision/eye phenotype J:201866
Pmp22Tr-3H/Pmp22+
involves: BALB/c * C3H/HeH 		abnormal gait J:79382
abnormal motor coordination/balance J:79382
abnormal Schwann cell morphology J:79382
axon degeneration J:79382
decreased grip strength J:79382
decreased locomotor activity J:79382
demyelination J:79382
impaired coordination J:79382
impaired righting response J:79382
tremors J:79382
Pmp22Tr-J/Pmp22+
B6.Cg-Pmp22Tr-J Krt25Re/+ +/J 		abnormal action potential J:101812
abnormal autophagy J:119095
abnormal cell physiology J:97015
demyelination J:101812
Pmp22Tr-J/Pmp22+
involves: C57BL/6 		abnormal axon morphology J:134811
abnormal dorsal root ganglion morphology J:39953
abnormal gait J:39953
abnormal myelination J:39953, J:98231
abnormal Schwann cell morphology J:39953, J:134811
impaired coordination J:134811
muscle degeneration J:39953
Pmp22Tr-J/?
involves: C57BL/6J 		abnormal gait J:7222
abnormal myelination J:7222
abnormal Schwann cell morphology J:7222
axon degeneration J:76795
decreased myelin sheath thickness J:76795
dysmyelination J:76795
increased Schwann cell number J:76795
tremors J:7222
Pmp22Tr-J/Pmp22Tr-J
involves: C57BL/6 		abnormal motor coordination/balance J:7945
decreased survivor rate J:7945
postnatal lethality J:7945
Pmp22Tr-Ncnp/Pmp22+
GAD/Ncnp-Pmp22Tr-Ncnp 		abnormal gait J:43874
demyelination J:43874
Pmp22Tr-Ncnp/Pmp22Tr-Ncnp
GAD/Ncnp-Pmp22Tr-Ncnp 		abnormal gait J:43874
abnormal myelination J:43874
abnormal Schwann cell morphology J:43874
Pmp22Tr/?
involves: CBA 		abnormal Schwann cell morphology J:98118
Pmp22Tr/Pmp22+
Not Specified 		abnormal gait J:13038, J:27475
abnormal Schwann cell morphology J:27475
convulsive seizures J:13038
decreased body size J:13038
demyelination J:27475
forelimb paralysis J:13038
hindlimb paralysis J:13038
lethality at weaning, complete penetrance J:13038
normal mortality/aging J:27475
postnatal growth retardation J:13038
reduced male fertility J:13038
tremors J:13038, J:27475
Pmp22Tr/?
Not Specified 		abnormal gait J:7222
abnormal myelination J:7222
abnormal Schwann cell morphology J:7222
seizures J:7222
tremors J:7222
Pmp22Tr/Pmp22Tr
Not Specified 		abnormal gait J:27475
abnormal Schwann cell morphology J:27475
demyelination J:27475
normal mortality/aging J:27475
tremors J:27475
Tg(Pmp22)247Ueli/0
involves: C3H * C57BL/6 		abnormal myelination J:98118
abnormal Schwann cell morphology J:98118
Tg(Pmp22)My41Clh/0
involves: C57BL/6J * CBA/Ca 		abnormal gait J:76795
abnormal myelination J:76795
abnormal submucous nerve plexus morphology J:76795
axon degeneration J:76795
decreased myelin sheath thickness J:76795
demyelination J:76795
dysmyelination J:76795
increased Schwann cell number J:76795
male infertility J:76795
premature death J:76795
reduced female fertility J:76795
weakness J:76795
Tg(PMP22-tTA)JY13Clh/0
Tg(tetO/CMV-Pmp22)JP18Clh/0
involves: C57BL/6J * CBA/Ca 		abnormal gait J:69545
abnormal myelination J:69545
decreased myelin sheath thickness J:69545
decreased nerve conduction velocity J:69545
demyelination J:69545
increased Schwann cell number J:69545
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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09/03/2024
MGI 6.24 		The Jackson Laboratory